CRP

Name	C-reactive protein
Structure
Interactors	22 interactors: APCS C1QA CFH ESS2 FCGR1A FCGR2A FCGR2B FN1 GLUD1 GMPPA GP6 H1-1 H2AC16 H2AC20 LAMC3 LEP MAPK1 MAPK3 MAPK8IP2 RPL13A SNRNP70 UBE3A
GO Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	Complement Component C1q Complex Binding Calcium Ion Binding Protein Binding Low-density Lipoprotein Particle Binding Choline Binding Identical Protein Binding Virion Binding Metal Ion Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Acute-phase Response Inflammatory Response Opsonization Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Regulation Of Interleukin-8 Production Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Mononuclear Cell Proliferation Vasoconstriction Innate Immune Response Defense Response To Gram-positive Bacterium
Pathways	Classical antibody-mediated complement activation
Drugs	N,N,N-Trimethyl-2-(phosphonooxy)ethanaminium CRx-139
Diseases	Systemic lupus erythematosus
GWAS	Blood protein levels ( 30072576 23696881 ) C-reactive protein ( 18439548 18439552 23844046 19567438 21196492 21647738 22492993 22939635 ) C-reactive protein levels ( 28548082 24763700 29403010 29878111 30388399 33227023 33339817 21300955 ) C-reactive protein levels in ischemic stroke ( 26718567 ) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809 ) Erythropoietin levels ( 33227023 ) High-sensitivity C-reactive protein levels in HIV infection ( 33095540 ) Inflammatory biomarkers ( 22291609 ) Inflammatory biomarkers in Kawasaki disease ( 25266886 ) Lung cancer ( 18385676 ) Metabolic traits ( 19060910 ) Protein quantitative trait loci ( 18464913 ) Select biomarker traits ( 17903293 ) Serum C-reactive protein concentration ( 32928877 ) Serum C-reactive protein concentration in obesity ( 32928877 ) Serum C-reactive protein concentration in visceral obesity (waist circumference) ( 32928877 )
Entrez ID	1401
HPRD ID	00422
Ensembl ID	ENSG00000132693
Uniprot IDs	P02741 Q5VVP7
PDB IDs	1B09 1GNH 1LJ7 3L2Y 3PVN 3PVO 7PK9 7PKB 7PKD 7PKE 7PKF 7PKG 7PKH 7TBA 8WV4 8WV5
GO Terms Enriched among Interactors ?	IgG Binding Acute Inflammatory Response IgG Receptor Activity Regulation Of Immune System Process Antibody-dependent Cellular Cytotoxicity Hypersensitivity Acute Inflammatory Response To Antigenic Stimulus Regulation Of Immune Response Interleukin-34-mediated Signaling Pathway Lung Morphogenesis Fc-gamma Receptor Signaling Pathway Endocytosis Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Inflammatory Response To Antigenic Stimulus Regulation Of Stress-activated MAPK Cascade Caveolin-mediated Endocytosis Regulation Of Golgi Inheritance Positive Regulation Of Macrophage Proliferation Regulation Of Stress-activated Protein Kinase Signaling Cascade Immunoglobulin Mediated Immune Response Positive Regulation Of Immune System Process Regulation Of Leukocyte Proliferation Regulation Of Acute Inflammatory Response B Cell Mediated Immunity Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Positive Regulation Of Endocytosis Fc Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Regulation Of Defense Response Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Positive Regulation Of Leukocyte Proliferation Regulation Of Tumor Necrosis Factor Production Bergmann Glial Cell Differentiation Glial Cell Development Import Into Cell Negative Regulation Of Acute Inflammatory Response Regulation Of Lymphocyte Mediated Immunity Immune Effector Process Positive Regulation Of Phagocytosis Leukocyte Mediated Cytotoxicity Regulation Of Cell Activation Response To External Biotic Stimulus Regulation Of MAPK Cascade Regulation Of Natural Killer Cell Proliferation Immune Response-regulating Signaling Pathway Regulation Of Inflammatory Response