WDR6

Name	WD repeat domain 6
Structure	No pdb structure
Novel Interactors	1 novel interactors: SCAP
Interactors	6 interactors: BRCA1 CDC42EP4 G2E3 GRIP1 PTPN3 UBC
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane COP9 Signalosome
	Molecular Function	TRNA Binding RNA Binding Protein Binding Enzyme Regulator Activity
	Biological Process	Wobble Position Ribose Methylation TRNA Processing Negative Regulation Of Cell Population Proliferation Negative Regulation Of Autophagy TRNA Methylation G1 To G0 Transition
Pathways	RHOU GTPase cycle RHOV GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
GWAS	Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 ) Menarche (age at onset) ( 25231870 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Ulcerative colitis ( 28067908 )
Entrez ID	11180
HPRD ID	06912
Ensembl ID	ENSG00000178252
Uniprot IDs	A0A087X295 B3KRR8 B4E256 E9PDU5 Q9H9M3 Q9NNW5
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Regulation Of Fatty Acid Biosynthetic Process Histone H2AK127 Ubiquitin Ligase Activity Negative Regulation Of Lipid Biosynthetic Process Histone H2AK129 Ubiquitin Ligase Activity Intracellular Signal Transduction Negative Regulation Of Lipid Metabolic Process BRCA1-BARD1 Complex Regulation Of Fatty Acid Metabolic Process Response To Vitamin B3 SREBP-SCAP Complex Negative Regulation Of Small Molecule Metabolic Process Negative Regulation Of Centrosome Duplication Negative Regulation Of Centriole Replication BRCA1-A Complex XY Body BRCA1-B Complex Post-translational Protein Modification Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Lateral Element Nuclear Ubiquitin Ligase Complex Cellular Response To Indole-3-methanol Regulation Of Anatomical Structure Morphogenesis BRCA1-C Complex Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Gamma-tubulin Ring Complex Ubiquitin-modified Histone Reader Activity Regulation Of Ketone Metabolic Process Response To Indole-3-methanol Negative Regulation Of Mitotic Cell Cycle Ubiquitin Protein Ligase Binding Protein Modification By Small Protein Conjugation DNA Strand Resection Involved In Replication Fork Processing Ubiquitin-protein Transferase Activity Regulation Of Lipid Biosynthetic Process Protein Ubiquitination DNA Repair Complex Random Inactivation Of X Chromosome Negative Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Membrane Depolarization During Action Potential Protein Tag Activity Sterol Binding Response To Sterol Depletion Negative Regulation Of Cholesterol Biosynthetic Process SREBP Signaling Pathway Negative Regulation Of Cholesterol Metabolic Process Cellular Response To Sterol Depletion Endomembrane System Endosome To Plasma Membrane Protein Transport Establishment Of Protein Localization To Postsynaptic Membrane Positive Regulation Of Neuron Projection Arborization