ADAM10

Name	ADAM metallopeptidase domain 10
Structure
Novel Interactors	2 novel interactors: MAP3K8 TCF12
Interactors	7 interactors: AXL DLL1 EFNA1 EFNA2 EPHA3 SH3D19 TGFA
GO Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Lumen Golgi Apparatus Golgi-associated Vesicle Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Postsynaptic Density Membrane Clathrin-coated Vesicle Axon Dendrite Cytoplasmic Vesicle Specific Granule Membrane Cell Projection Pore Complex Extracellular Exosome Anchoring Junction Tertiary Granule Membrane Perinuclear Endoplasmic Reticulum Synaptic Membrane Tetraspanin-enriched Microdomain Glutamatergic Synapse
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Integrin Binding Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity SH3 Domain Binding Protein Kinase Binding Protein Homodimerization Activity Metal Ion Binding Metallodipeptidase Activity Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
	Biological Process	In Utero Embryonic Development Proteolysis Membrane Protein Ectodomain Proteolysis Negative Regulation Of Cell Adhesion Notch Signaling Pathway Integrin-mediated Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Regulation Of Notch Signaling Pathway Negative Regulation Of Gene Expression Positive Regulation Of T Cell Chemotaxis Protein Processing Extracellular Matrix Disassembly Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Tumor Necrosis Factor Production Adherens Junction Organization Response To Tumor Necrosis Factor Epidermal Growth Factor Receptor Ligand Maturation Monocyte Activation Amyloid Precursor Protein Catabolic Process Pore Complex Assembly Constitutive Protein Ectodomain Proteolysis Cochlea Development Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Postsynapse Organization Regulation Of Postsynapse Organization Protein Catabolic Process At Postsynapse Signaling Receptor Ligand Precursor Processing Regulation Of Vasculature Development Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Pathways	Collagen degradation Degradation of the extracellular matrix Signaling by EGFR Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Neutrophil degranulation Post-translational protein phosphorylation NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Amyloid fiber formation
Drugs	XL784
GWAS	Alzheimer's disease (late onset) ( 30820047 ) Alzheimer's disease or family history of Alzheimer's disease ( 30617256 33589840 ) Apolipoprotein A1 levels ( 32203549 ) Chronotype ( 30696823 ) Diffusing capacity of carbon monoxide ( 30694715 ) Family history of Alzheimer's disease ( 30617256 ) Levodopa-induced dyskinesia in levodopa treated Parkinson's disease ( 32733355 ) Metabolite levels ( 23823483 ) Schizophrenia ( 30285260 )
Entrez ID	102
HPRD ID	03723
Ensembl ID	ENSG00000137845
Uniprot IDs	O14672
PDB IDs	6BDZ 6BE6 8ESV
GO Terms Enriched among Interactors ?	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Ephrin Receptor Binding Cell Surface Receptor Signaling Pathway Neuron Projection Guidance Axon Guidance Substrate Adhesion-dependent Cell Spreading Transmembrane Receptor Protein Tyrosine Kinase Activity Negative Regulation Of Leukocyte Apoptotic Process Regulation Of Endocytosis Regulation Of Developmental Process Regulation Of Cell Adhesion Notch Signaling Pathway Involved In Arterial Endothelial Cell Fate Commitment Cerebellar Molecular Layer Formation Regulation Of Cell Differentiation Leukocyte Differentiation Tissue Remodeling Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Fasciculation Of Motor Neuron Axon Endothelial Tip Cell Fate Specification Cerebellar Purkinje Cell Layer Structural Organization Positive Regulation Of Cellular Component Organization Signal Transduction Protein Kinase Activity Protein Tyrosine Kinase Activity Plasma Membrane Neuron Projection Development Notochord Formation Endocardial Cushion To Mesenchymal Transition Negative Regulation Of Dendritic Spine Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Side Of Membrane Fasciculation Of Sensory Neuron Axon Receptor Ligand Activity Negative Regulation Of Inner Ear Receptor Cell Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Compartment Pattern Specification Lateral Inhibition Blood Vessel Endothelial Cell Fate Specification Endothelial Cell Fate Specification Regulation Of Vesicle-mediated Transport Positive Regulation Of Skeletal Muscle Tissue Growth Loop Of Henle Development Somite Specification Positive Regulation Of Endocytosis Positive Regulation Of Pinocytosis Kinase Activity Neutrophil Clearance Cell-substrate Adhesion