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PRMT3

Name protein arginine methyltransferase 3
Structure PDB 2FYT
Interactors 11 interactors: BEND7 FBL HNRNPA1 MEOX2 PABPN1 PIH1D2 PPARD RASSF2 STAT1 TMEM132D TSC22D2
GO Annotations Cellular Component
  • Nucleus
  • Cytoplasm
  • Cytosol
Molecular Function
  • Protein Binding
  • Methyltransferase Activity
  • Zinc Ion Binding
  • Protein-arginine N-methyltransferase Activity
  • Transferase Activity
  • Protein-arginine Omega-N Monomethyltransferase Activity
  • Protein-arginine Omega-N Asymmetric Methyltransferase Activity
  • Histone Methyltransferase Activity
  • Histone H4R3 Methyltransferase Activity
  • Metal Ion Binding
Biological Process
  • Chromatin Remodeling
  • Regulation Of DNA-templated Transcription
  • Negative Regulation Of Protein Ubiquitination
  • Methylation
  • Positive Regulation Of Osteoblast Differentiation
  • Transcription Initiation-coupled Chromatin Remodeling
  • Negative Regulation Of Retinoic Acid Biosynthetic Process
Pathways
  • RMTs methylate histone arginines
  • Protein methylation
Drugs
  • S-adenosyl-L-homocysteine
GWAS
  • Carotid intima media thickness (maximum) ( 31801372 )
  • Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906 )
  • Pursuit maintenance gain ( 29064472 )
  • Response to inhaled glucocorticoid treatment in asthma (change in FEV1) ( 25601762 )
Entrez ID 10196
HPRD ID 11934
Ensembl ID ENSG00000185238
Uniprot IDs O60678 Q8WUV3
PDB IDs 2FYT 3SMQ 4HSG 4QQN 4RYL 8G2F 8G2G 8SHB 8SHR 8SIO
GO Terms Enriched among Interactors ?
  • Ribonucleoprotein Complex

© Madhavi K. Ganapathiraju 2012-2026