TP53 |
tumor protein p53 |
- Cellular Senescence
- Activation of BH3-only proteins
- p53-Dependent G1/S DNA damage checkpoint
- Oncogene Induced Senescence
- p53-Dependent G1 DNA Damage Response
- Formation of Senescence-Associated Heterochromatin Foci (SAHF)
- Pre-NOTCH Transcription and Translation
- Stabilization of p53
- Transcriptional activation of p53 responsive genes
- Programmed Cell Death
- Pre-NOTCH Expression and Processing
- G1/S DNA Damage Checkpoints
- Intrinsic Pathway for Apoptosis
- Transcriptional activation of cell cycle inhibitor p21
- DNA Damage/Telomere Stress Induced Senescence
- Signaling by NOTCH
- Factors involved in megakaryocyte development and platelet production
- Activation of NOXA and translocation to mitochondria
- Oxidative Stress Induced Senescence
- Autodegradation of the E3 ubiquitin ligase COP1
- Activation of PUMA and translocation to mitochondria
- Cell Cycle Checkpoints
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MYC |
v-myc avian myelocytomatosis viral oncogene homolog |
- Loss of Function of TGFBR2 in Cancer
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- Signaling by Wnt
- Cyclin E associated events during G1/S transition
- binding of TCF/LEF:CTNNB1 to target gene promoters
- TGFBR1 LBD Mutants in Cancer
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Generic Transcription Pathway
- RNF mutants show enhanced WNT signaling and proliferation
- G1/S Transition
- Signaling by NOTCH1
- XAV939 inhibits tankyrase, stabilizing AXIN
- Signaling by NOTCH1 in Cancer
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Mitotic G1-G1/S phases
- FBXW7 Mutants and NOTCH1 in Cancer
- TGFBR2 MSI Frameshift Mutants in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- Loss of Function of SMAD2/3 in Cancer
- Signaling by NOTCH
- formation of the beta-catenin:TCF transactivating complex
- TGFBR2 Kinase Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- S Phase
- Cell Cycle, Mitotic
- Loss of Function of TGFBR1 in Cancer
- NOTCH1 Intracellular Domain Regulates Transcription
- Signaling by TGF-beta Receptor Complex in Cancer
- Signaling by TGF-beta Receptor Complex
- TCF dependent signaling in response to WNT
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Cyclin A:Cdk2-associated events at S phase entry
- Signaling by WNT in cancer
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- SMAD4 MH2 Domain Mutants in Cancer
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RB1 |
retinoblastoma 1 |
- E2F mediated regulation of DNA replication
- DNA Damage/Telomere Stress Induced Senescence
- Synthesis of DNA
- Mitotic Prophase
- Cellular Senescence
- G1 Phase
- Regulation of DNA replication
- Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
- Orc1 removal from chromatin
- S Phase
- Cyclin E associated events during G1/S transition
- Cell Cycle, Mitotic
- M Phase
- Orc1 removal from chromatin
- Cyclin D associated events in G1
- Formation of Senescence-Associated Heterochromatin Foci (SAHF)
- G1/S Transition
- Removal of licensing factors from origins
- Cyclin A:Cdk2-associated events at S phase entry
- Switching of origins to a post-replicative state
- Mitotic G1-G1/S phases
- Condensation of Prophase Chromosomes
- Inhibition of replication initiation of damaged DNA by RB1/E2F1
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CCND1 |
cyclin D1 |
- Chromatin organization
- Signaling by NOTCH
- Ubiquitin-dependent degradation of Cyclin D
- G1 Phase
- S Phase
- Cell Cycle, Mitotic
- RMTs methylate histone arginines
- Ubiquitin-dependent degradation of Cyclin D1
- Cyclin D associated events in G1
- Chromatin modifying enzymes
- Pre-NOTCH Transcription and Translation
- Pre-NOTCH Expression and Processing
- Mitotic G1-G1/S phases
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CTNNB1 |
catenin (cadherin-associated protein), beta 1, 88kDa |
- APC truncation mutants have impaired AXIN binding
- misspliced GSK3beta mutants stabilize beta-catenin
- T41 mutants of beta-catenin aren't phosphorylated
- TCF7L2 mutants don't bind CTBP
- truncated APC mutants destabilize the destruction complex
- Signaling by Wnt
- binding of TCF/LEF:CTNNB1 to target gene promoters
- deactivation of the beta-catenin transactivating complex
- APC truncation mutants are not K63 polyubiquitinated
- disassembly of the destruction complex and recruitment of AXIN to the membrane
- S37 mutants of beta-catenin aren't phosphorylated
- Degradation of beta-catenin by the destruction complex
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- RNF mutants show enhanced WNT signaling and proliferation
- S33 mutants of beta-catenin aren't phosphorylated
- XAV939 inhibits tankyrase, stabilizing AXIN
- Innate Immune System
- truncations of AMER1 destabilize the destruction complex
- CDO in myogenesis
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- Cytosolic sensors of pathogen-associated DNA
- formation of the beta-catenin:TCF transactivating complex
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- AXIN missense mutants destabilize the destruction complex
- S45 mutants of beta-catenin aren't phosphorylated
- repression of WNT target genes
- beta-catenin independent WNT signaling
- deletions in the AMER1 gene destabilize the destruction complex
- Ca2+ pathway
- Myogenesis
- AMER1 mutants destabilize the destruction complex
- TCF dependent signaling in response to WNT
- LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- Signaling by WNT in cancer
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AR |
androgen receptor |
- Generic Transcription Pathway
- Nuclear Receptor transcription pathway
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- Levonorgestrel
- Spironolactone
- Flutamide
- Oxandrolone
- Testosterone
- Nilutamide
- Fludrocortisone
- Drostanolone
- Nandrolone phenpropionate
- Bicalutamide
- Fluoxymesterone
- Drospirenone
- Danazol
- Testosterone Propionate
- Delta1-dihydrotestosterone
- Boldenone
- Calusterone
- Flufenamic Acid
- Dihydrotestosterone
- (2r)-N-[4-Cyano-3-(Trifluoromethyl)Phenyl]-3-[(4-Fluorophenyl)Sulfonyl]-2-Hydroxy-2-Methylpropanamide
- Methyltrienolone
- (3AALPHA,4ALPHA,7ALPHA,7AALPHA)- 3A,4,7,7A-TETRAHYDRO-2-(4-NITRO-1-NAPHTHALENYL)-4,7-ETHANO-1H-ISOINDOLE-1,3(2H)-DIONE
- Cyproterone
- Methyltestosterone
- 17-HYDROXY-18A-HOMO-19-NOR-17ALPHA-PREGNA-4,9,11-TRIEN-3-ONE
- (2S)-N-(4-cyano-3-iodophenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide
- 2-CHLORO-4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-3-METHYLBENZONITRILE
- (2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide
- 4-{[(1R,2S)-1,2-dihydroxy-2-methyl-3-(4-nitrophenoxy)propyl]amino}-2-(trifluoromethyl)benzonitrile
- (2S)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-(pentafluorophenoxy)propanamide
- (2S)-3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
- (R)-3-BROMO-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE
- (5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-3-ONE
- S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE
- 1-TERT-BUTYL-3-(2,5-DIMETHYLBENZYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE
- 4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-1-NAPHTHONITRILE
- 2-chloro-4-{[(1R,3Z,7S,7aS)-7-hydroxy-1-(trifluoromethyl)tetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-3-ylidene]amino}-3-methylbenzonitrile
- 6-[BIS(2,2,2-TRIFLUOROETHYL)AMINO]-4-(TRIFLUOROMETHYL)QUINOLIN-2(1H)-ONE
- 3-[(4-AMINO-1-TERT-BUTYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL)METHYL]PHENOL
- Nandrolone decanoate
- Enzalutamide
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ATM |
ATM serine/threonine kinase |
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- Fanconi Anemia pathway
- G2/M Checkpoints
- Cellular Senescence
- p53-Dependent G1/S DNA damage checkpoint
- p53-Dependent G1 DNA Damage Response
- Regulation of the Fanconi anemia pathway
- Stabilization of p53
- p53-Independent DNA Damage Response
- Homologous recombination repair of replication-independent double-strand breaks
- p53-Independent G1/S DNA damage checkpoint
- Double-Strand Break Repair
- G1/S DNA Damage Checkpoints
- ATM mediated phosphorylation of repair proteins
- DNA Damage/Telomere Stress Induced Senescence
- Meiotic recombination
- ATM mediated response to DNA double-strand break
- G2/M DNA damage checkpoint
- Regulation of HSF1-mediated heat shock response
- Cellular response to heat stress
- Autodegradation of the E3 ubiquitin ligase COP1
- Homologous Recombination Repair
- Recruitment of repair and signaling proteins to double-strand breaks
- Cell Cycle Checkpoints
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BRCA2 |
breast cancer 2, early onset |
- Homologous DNA pairing and strand exchange
- Meiotic recombination
- Fanconi Anemia pathway
- Homologous Recombination Repair
- Homologous recombination repair of replication-independent double-strand breaks
- Double-Strand Break Repair
- Presynaptic phase of homologous DNA pairing and strand exchange
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DES |
desmin |
- Striated Muscle Contraction
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MLH1 |
mutL homolog 1 |
- Meiotic recombination
- Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
- Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
- Mismatch Repair
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SMAD4 |
SMAD family member 4 |
- Loss of Function of TGFBR2 in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- TGF-beta receptor signaling activates SMADs
- TGFBR1 LBD Mutants in Cancer
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- Signaling by BMP
- Transcriptional regulation of pluripotent stem cells
- Generic Transcription Pathway
- Signaling by NODAL
- TGFBR2 MSI Frameshift Mutants in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Loss of Function of SMAD2/3 in Cancer
- Signaling by Activin
- TGFBR2 Kinase Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Signaling by TGF-beta Receptor Complex in Cancer
- Signaling by TGF-beta Receptor Complex
- SMAD4 MH2 Domain Mutants in Cancer
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CDK4 |
cyclin-dependent kinase 4 |
- Meiotic recombination
- Chromatin organization
- Ubiquitin-dependent degradation of Cyclin D
- Cellular Senescence
- G1 Phase
- Senescence-Associated Secretory Phenotype (SASP)
- S Phase
- Oncogene Induced Senescence
- Cell Cycle, Mitotic
- Ubiquitin-dependent degradation of Cyclin D1
- RMTs methylate histone arginines
- Cyclin D associated events in G1
- Chromatin modifying enzymes
- Oxidative Stress Induced Senescence
- Transcriptional regulation of white adipocyte differentiation
- Mitotic G1-G1/S phases
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COL1A1 |
collagen, type I, alpha 1 |
- Platelet Adhesion to exposed collagen
- Collagen formation
- Collagen degradation
- Anchoring fibril formation
- Non-integrin membrane-ECM interactions
- Degradation of the extracellular matrix
- Assembly of collagen fibrils and other multimeric structures
- Cell surface interactions at the vascular wall
- Syndecan interactions
- Crosslinking of collagen fibrils
- ECM proteoglycans
- GPVI-mediated activation cascade
- Integrin cell surface interactions
- Collagen biosynthesis and modifying enzymes
- Platelet activation, signaling and aggregation
- Scavenging by Class A Receptors
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ERCC6 |
excision repair cross-complementation group 6 |
- Nucleotide Excision Repair
- RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
- Transcription-coupled NER (TC-NER)
- RNA Polymerase I Transcription
- RNA Polymerase I Transcription Initiation
- RNA Polymerase I Promoter Clearance
- Formation of transcription-coupled NER (TC-NER) repair complex
- Dual incision reaction in TC-NER
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MSH2 |
mutS homolog 2 |
- Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
- Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
- Mismatch Repair
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POMGNT1 |
protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) |
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PSAP |
prosaposin |
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signaling by GPCR
- Sphingolipid metabolism
- Metabolism of lipids and lipoproteins
- Glycosphingolipid metabolism
- Class A/1 (Rhodopsin-like receptors)
- Platelet degranulation
- Metabolic disorders of biological oxidation enzymes
- GPCR ligand binding
- Peptide ligand-binding receptors
- Response to elevated platelet cytosolic Ca2+
- Platelet activation, signaling and aggregation
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- Di-Stearoyl-3-Sn-Phosphatidylethanolamine
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SETX |
senataxin |
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ABL1 |
ABL proto-oncogene 1, non-receptor tyrosine kinase |
- Role of Abl in Robo-Slit signaling
- CDO in myogenesis
- Axon guidance
- Myogenesis
- Fcgamma receptor (FCGR) dependent phagocytosis
- Factors involved in megakaryocyte development and platelet production
- Signaling by Robo receptor
- Regulation of actin dynamics for phagocytic cup formation
- Innate Immune System
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- Adenosine triphosphate
- Imatinib
- Dasatinib
- N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide
- Nilotinib
- Bosutinib
- 2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE
- 1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA
- MYRISTIC ACID
- 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE
- 5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE
- 2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide
- Regorafenib
- Ponatinib
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ATR |
ATR serine/threonine kinase |
- Fanconi Anemia pathway
- G2/M DNA damage checkpoint
- G2/M Checkpoints
- Meiotic synapsis
- Regulation of HSF1-mediated heat shock response
- Cellular response to heat stress
- Regulation of the Fanconi anemia pathway
- Activation of ATR in response to replication stress
- Cell Cycle Checkpoints
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HSPD1 |
heat shock 60kDa protein 1 (chaperonin) |
- Mitochondrial protein import
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JUP |
junction plakoglobin |
- Cell junction organization
- Cell-cell junction organization
- Signaling by VEGF
- Adherens junctions interactions
- VEGFR2 mediated vascular permeability
- VEGFA-VEGFR2 Pathway
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MRE11A |
MRE11 meiotic recombination 11 homolog A (S. cerevisiae) |
- Meiotic recombination
- DNA Damage/Telomere Stress Induced Senescence
- MRN complex relocalizes to nuclear foci
- Cytosolic sensors of pathogen-associated DNA
- Cellular Senescence
- Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
- Homologous Recombination Repair
- STING mediated induction of host immune responses
- Homologous recombination repair of replication-independent double-strand breaks
- Recruitment of repair and signaling proteins to double-strand breaks
- Double-Strand Break Repair
- IRF3-mediated induction of type I IFN
- Innate Immune System
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MSH6 |
mutS homolog 6 |
- Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
- Mismatch Repair
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RPGRIP1 |
retinitis pigmentosa GTPase regulator interacting protein 1 |
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STAT1 |
signal transducer and activator of transcription 1, 91kDa |
- Signaling by PDGF
- Signaling by FGFR in disease
- ISG15 antiviral mechanism
- Interferon Signaling
- Cytokine Signaling in Immune system
- Antiviral mechanism by IFN-stimulated genes
- Signaling by SCF-KIT
- Downstream signal transduction
- Signaling by FGFR1 mutants
- Signaling by FGFR mutants
- Signaling by FGFR1 fusion mutants
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STAT3 |
signal transducer and activator of transcription 3 (acute-phase response factor) |
- Signaling by PDGF
- Signalling by NGF
- Signaling by FGFR in disease
- Cellular Senescence
- Interleukin-6 signaling
- Senescence-Associated Secretory Phenotype (SASP)
- Cytokine Signaling in Immune system
- NGF signalling via TRKA from the plasma membrane
- Signaling by SCF-KIT
- Signaling by Interleukins
- Transcriptional regulation of pluripotent stem cells
- Downstream signal transduction
- Signaling by FGFR1 mutants
- Signalling to STAT3
- Signaling by FGFR mutants
- Signaling by FGFR1 fusion mutants
- POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
- Signaling by Leptin
- Growth hormone receptor signaling
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USH2A |
Usher syndrome 2A (autosomal recessive, mild) |
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AKT1 |
v-akt murine thymoma viral oncogene homolog 1 |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Signaling by FGFR in disease
- Activation of BH3-only proteins
- Signaling by Wnt
- Platelet Aggregation (Plug Formation)
- Signaling by EGFRvIII in Cancer
- AKT phosphorylates targets in the cytosol
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- Regulation of beta-cell development
- PI3K/AKT activation
- PI-3K cascade
- RNF mutants show enhanced WNT signaling and proliferation
- Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
- Signaling by PDGF
- Downregulation of ERBB2:ERBB3 signaling
- DAP12 interactions
- Regulation of mRNA stability by proteins that bind AU-rich elements
- GAB1 signalosome
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- G-protein beta:gamma signalling
- CD28 co-stimulation
- CD28 dependent PI3K/Akt signaling
- Signaling by ERBB4
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- PI3K events in ERBB4 signaling
- Signaling by ERBB2
- Activation of BAD and translocation to mitochondria
- Signaling by EGFR
- GPCR downstream signaling
- Signaling by VEGF
- AKT phosphorylates targets in the nucleus
- Downstream signal transduction
- Regulation of gene expression in beta cells
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- PI3K/AKT Signaling in Cancer
- Platelet activation, signaling and aggregation
- Adaptive Immune System
- Costimulation by the CD28 family
- PIP3 activates AKT signaling
- Translocation of GLUT4 to the plasma membrane
- deactivation of the beta-catenin transactivating complex
- VEGFA-VEGFR2 Pathway
- Metabolism of nitric oxide
- G beta:gamma signalling through PI3Kgamma
- PI3K events in ERBB2 signaling
- VEGFR2 mediated vascular permeability
- Downstream signaling of activated FGFR
- Programmed Cell Death
- XAV939 inhibits tankyrase, stabilizing AXIN
- eNOS activation and regulation
- Intrinsic Pathway for Apoptosis
- Butyrate Response Factor 1 (BRF1) destabilizes mRNA
- Innate Immune System
- Signalling by NGF
- CTLA4 inhibitory signaling
- AKT-mediated inactivation of FOXO1A
- Integrin alphaIIb beta3 signaling
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Negative regulation of the PI3K/AKT network
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- eNOS activation
- TCF dependent signaling in response to WNT
- KSRP destabilizes mRNA
- GPVI-mediated activation cascade
- Signaling by WNT in cancer
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- Adenosine triphosphate
- Arsenic trioxide
- Inositol 1,3,4,5-Tetrakisphosphate
- N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
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ATF1 |
activating transcription factor 1 |
- CREB phosphorylation
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- CREB phosphorylation
- Toll Like Receptor TLR6:TLR2 Cascade
- Activated TLR4 signalling
- Toll Like Receptor TLR1:TLR2 Cascade
- MyD88 cascade initiated on plasma membrane
- Toll Like Receptor 5 (TLR5) Cascade
- MyD88 dependent cascade initiated on endosome
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- MyD88:Mal cascade initiated on plasma membrane
- Toll Like Receptor 9 (TLR9) Cascade
- Innate Immune System
- Signalling by NGF
- TRIF-mediated TLR3/TLR4 signaling
- MAP kinase activation in TLR cascade
- NGF signalling via TRKA from the plasma membrane
- MyD88-independent cascade
- Toll Like Receptor 2 (TLR2) Cascade
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- MAPK targets/ Nuclear events mediated by MAP kinases
- Nuclear Events (kinase and transcription factor activation)
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BRIP1 |
BRCA1 interacting protein C-terminal helicase 1 |
- Homologous DNA pairing and strand exchange
- Cytosolic iron-sulfur cluster assembly
- Homologous Recombination Repair
- Homologous recombination repair of replication-independent double-strand breaks
- Double-Strand Break Repair
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CHEK2 |
checkpoint kinase 2 |
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CREBBP |
CREB binding protein |
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Metabolism of lipids and lipoproteins
- Signaling by Wnt
- Regulation of gene expression by Hypoxia-inducible Factor
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Generic Transcription Pathway
- Pre-NOTCH Transcription and Translation
- RNF mutants show enhanced WNT signaling and proliferation
- Signaling by NOTCH1 in Cancer
- Orphan transporters
- Chromatin organization
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- Signaling by NOTCH
- formation of the beta-catenin:TCF transactivating complex
- Factors involved in megakaryocyte development and platelet production
- Chromatin modifying enzymes
- LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Activation of gene expression by SREBF (SREBP)
- Transcriptional activation of mitochondrial biogenesis
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- PPARA activates gene expression
- Cellular response to hypoxia
- Organelle biogenesis and maintenance
- Regulation of Hypoxia-inducible Factor (HIF) by oxygen
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Attenuation phase
- HATs acetylate histones
- RORA activates circadian gene expression
- Regulation of cholesterol biosynthesis by SREBP (SREBF)
- HSF1-dependent transactivation
- TRAF3-dependent IRF activation pathway
- Signaling by NOTCH1
- Transcriptional regulation of white adipocyte differentiation
- XAV939 inhibits tankyrase, stabilizing AXIN
- Pre-NOTCH Expression and Processing
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Innate Immune System
- FBXW7 Mutants and NOTCH1 in Cancer
- Fatty acid, triacylglycerol, and ketone body metabolism
- Cytosolic sensors of pathogen-associated DNA
- Cellular response to heat stress
- REV-ERBA represses gene expression
- Mitochondrial biogenesis
- Notch-HLH transcription pathway
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- NOTCH1 Intracellular Domain Regulates Transcription
- TCF dependent signaling in response to WNT
- TRAF6 mediated IRF7 activation
- YAP1- and WWTR1 (TAZ)-stimulated gene expression
- Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
- Signaling by WNT in cancer
- BMAL1:CLOCK,NPAS2 activates circadian gene expression
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DCLRE1C |
DNA cross-link repair 1C |
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DCN |
decorin |
- MPS IIIB - Sanfilippo syndrome B
- Diseases of glycosylation
- Heparan sulfate/heparin (HS-GAG) metabolism
- Defective B4GALT7 causes EDS, progeroid type
- MPS I - Hurler syndrome
- MPS IX - Natowicz syndrome
- Chondroitin sulfate/dermatan sulfate metabolism
- CS/DS degradation
- Defective SLC26A2 causes chondrodysplasias
- Glycosaminoglycan metabolism
- Degradation of the extracellular matrix
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Defective CHST14 causes EDS, musculocontractural type
- Defective PAPSS2 causes SEMD-PA
- MPS IIIA - Sanfilippo syndrome A
- Myoclonic epilepsy of Lafora
- ECM proteoglycans
- Defective CHST6 causes MCDC1
- Glycogen storage diseases
- MPS IIID - Sanfilippo syndrome D
- A tetrasaccharide linker sequence is required for GAG synthesis
- Chondroitin sulfate biosynthesis
- MPS IIIC - Sanfilippo syndrome C
- Diseases associated with glycosaminoglycan metabolism
- Mucopolysaccharidoses
- Defective EXT2 causes exostoses 2
- MPS II - Hunter syndrome
- Defective B3GAT3 causes JDSSDHD
- Defective CHST3 causes SEDCJD
- Defective EXT1 causes exostoses 1, TRPS2 and CHDS
- MPS IV - Morquio syndrome A
- Dermatan sulfate biosynthesis
- MPS IV - Morquio syndrome B
- Defective CHSY1 causes TPBS
- MPS VII - Sly syndrome
- Metabolism of carbohydrates
- MPS VI - Maroteaux-Lamy syndrome
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DYNC1H1 |
dynein, cytoplasmic 1, heavy chain 1 |
- Organelle biogenesis and maintenance
- Assembly of the primary cilium
- G2/M Transition
- Anchoring of the basal body to the plasma membrane
- Regulation of PLK1 Activity at G2/M Transition
- Cell Cycle, Mitotic
- Loss of proteins required for interphase microtubule organization from the centrosome
- Loss of Nlp from mitotic centrosomes
- MHC class II antigen presentation
- Centrosome maturation
- Mitotic G2-G2/M phases
- Recruitment of mitotic centrosome proteins and complexes
- Adaptive Immune System
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ELK4 |
ELK4, ETS-domain protein (SRF accessory protein 1) |
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EP300 |
E1A binding protein p300 |
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Metabolism of lipids and lipoproteins
- Signaling by Wnt
- NOTCH2 intracellular domain regulates transcription
- Regulation of gene expression by Hypoxia-inducible Factor
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Signaling by NOTCH2
- Pre-NOTCH Transcription and Translation
- RNF mutants show enhanced WNT signaling and proliferation
- Signaling by NOTCH1 in Cancer
- Chromatin organization
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- Signaling by NOTCH
- formation of the beta-catenin:TCF transactivating complex
- Factors involved in megakaryocyte development and platelet production
- Chromatin modifying enzymes
- LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Mitotic G2-G2/M phases
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- PPARA activates gene expression
- Cellular response to hypoxia
- Regulation of Hypoxia-inducible Factor (HIF) by oxygen
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Attenuation phase
- G2/M Transition
- HATs acetylate histones
- RORA activates circadian gene expression
- HSF1-dependent transactivation
- TRAF3-dependent IRF activation pathway
- Signaling by NOTCH1
- Transcriptional regulation of white adipocyte differentiation
- XAV939 inhibits tankyrase, stabilizing AXIN
- Pre-NOTCH Expression and Processing
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
- Innate Immune System
- Fatty acid, triacylglycerol, and ketone body metabolism
- Cytosolic sensors of pathogen-associated DNA
- Cellular response to heat stress
- REV-ERBA represses gene expression
- Cell Cycle, Mitotic
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- NOTCH1 Intracellular Domain Regulates Transcription
- TCF dependent signaling in response to WNT
- TRAF6 mediated IRF7 activation
- Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
- Signaling by WNT in cancer
- BMAL1:CLOCK,NPAS2 activates circadian gene expression
- Polo-like kinase mediated events
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ETV5 |
ets variant 5 |
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FAM161A |
family with sequence similarity 161, member A |
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FANCA |
Fanconi anemia, complementation group A |
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FANCD2 |
Fanconi anemia, complementation group D2 |
- Fanconi Anemia pathway
- Regulation of the Fanconi anemia pathway
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FLI1 |
Fli-1 proto-oncogene, ETS transcription factor |
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JAK2 |
Janus kinase 2 |
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Interferon gamma signaling
- Toll Like Receptor TLR1:TLR2 Cascade
- Toll Like Receptor 5 (TLR5) Cascade
- Interleukin receptor SHC signaling
- Gastrin-CREB signalling pathway via PKC and MAPK
- MyD88 dependent cascade initiated on endosome
- SOS-mediated signalling
- Prolactin receptor signaling
- SHC-mediated signalling
- TRIF-mediated TLR3/TLR4 signaling
- ERK1 activation
- ERK1 activation
- GPCR downstream signaling
- Signaling by VEGF
- Downstream signal transduction
- Toll Like Receptor 3 (TLR3) Cascade
- Signalling to RAS
- Interleukin-2 signaling
- Platelet activation, signaling and aggregation
- Frs2-mediated activation
- Axon guidance
- IRS-mediated signalling
- Interleukin-6 signaling
- VEGFA-VEGFR2 Pathway
- Activated TLR4 signalling
- VEGFR2 mediated cell proliferation
- GRB2 events in ERBB2 signaling
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- NCAM signaling for neurite out-growth
- RAF/MAP kinase cascade
- Signalling to p38 via RIT and RIN
- Innate Immune System
- Signaling by Insulin receptor
- Insulin receptor signalling cascade
- Interferon Signaling
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- IRS-related events
- SHC-related events
- RMTs methylate histone arginines
- Signaling by FGFR
- ARMS-mediated activation
- Toll-Like Receptors Cascades
- Nuclear signaling by ERBB4
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- Interleukin receptor SHC signaling
- GPVI-mediated activation cascade
- Signaling by GPCR
- FCERI mediated MAPK activation
- SHC1 events in ERBB2 signaling
- Signaling by SCF-KIT
- DAP12 signaling
- Toll Like Receptor 9 (TLR9) Cascade
- Signaling by PDGF
- DAP12 interactions
- G-protein beta:gamma signalling
- Chromatin organization
- GRB2 events in EGFR signaling
- SHC-related events triggered by IGF1R
- Factors involved in megakaryocyte development and platelet production
- Signaling by ERBB4
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- Chromatin modifying enzymes
- SHC1 events in ERBB4 signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- Interleukin-3, 5 and GM-CSF signaling
- Growth hormone receptor signaling
- Signaling by Leptin
- Signalling to ERKs
- Prolonged ERK activation events
- ERK activation
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- IGF1R signaling cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- IRS-related events triggered by IGF1R
- MyD88 cascade initiated on plasma membrane
- ERK activation
- G beta:gamma signalling through PI3Kgamma
- Downstream signaling of activated FGFR
- Signalling by NGF
- SOS-mediated signalling
- MAP kinase activation in TLR cascade
- SHC-mediated signalling
- Cytokine Signaling in Immune system
- NGF signalling via TRKA from the plasma membrane
- MyD88-independent cascade
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- ERK2 activation
- SHC1 events in EGFR signaling
- FRS2-mediated cascade
- IRS-mediated signalling
- ERK2 activation
- Regulation of IFNG signaling
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KIF1B |
kinesin family member 1B |
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LCK |
LCK proto-oncogene, Src family tyrosine kinase |
- Signaling by the B Cell Receptor (BCR)
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Nef and signal transduction
- Signaling by SCF-KIT
- DAP12 signaling
- Downstream signaling events of B Cell Receptor (BCR)
- Regulation of KIT signaling
- PI3K/AKT activation
- PI-3K cascade
- Signaling by PDGF
- DAP12 interactions
- GAB1 signalosome
- CD28 co-stimulation
- Host Interactions of HIV factors
- CD28 dependent PI3K/Akt signaling
- The role of Nef in HIV-1 replication and disease pathogenesis
- Signaling by ERBB4
- Constitutive PI3K/AKT Signaling in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- PI3K events in ERBB4 signaling
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- TCR signaling
- Downstream signal transduction
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- Interleukin-2 signaling
- PI3K/AKT Signaling in Cancer
- Platelet activation, signaling and aggregation
- Adaptive Immune System
- Downstream TCR signaling
- Costimulation by the CD28 family
- PIP3 activates AKT signaling
- HIV Infection
- PI3K events in ERBB2 signaling
- Downstream signaling of activated FGFR
- Nef Mediated CD4 Down-regulation
- Innate Immune System
- Signalling by NGF
- Generation of second messenger molecules
- Translocation of ZAP-70 to Immunological synapse
- Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
- CTLA4 inhibitory signaling
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Cytokine Signaling in Immune system
- NGF signalling via TRKA from the plasma membrane
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- CD28 dependent Vav1 pathway
- PECAM1 interactions
- Cell surface interactions at the vascular wall
- Signaling by FGFR
- PD-1 signaling
- GPVI-mediated activation cascade
- Phosphorylation of CD3 and TCR zeta chains
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- Dasatinib
- {4-[2-Acetylamino-2-(3-Carbamoyl-2-Cyclohexylmethoxy-6,7,8,9-Tetrahydro-5h-Benzocyclohepten-5ylcarbamoyl)-Ethyl]-2-Phosphono-Phenyl}-Phosphonic Acid
- Staurosporine
- 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
- (4-{2-Acetylamino-2-[1-(3-Carbamoyl-4-Cyclohexylmethoxy-Phenyl)-Ethylcarbamoyl}-Ethyl}-2-Phosphono-Phenoxy)-Acetic Acid
- Phosphoaminophosphonic Acid-Adenylate Ester
- 3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE
- 2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINE
- 5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE
- N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine
- N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine
- N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amine
- Ponatinib
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MSH3 |
mutS homolog 3 |
- Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
- Mismatch Repair
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NBN |
nibrin |
- ATM mediated phosphorylation of repair proteins
- Meiotic recombination
- DNA Damage/Telomere Stress Induced Senescence
- MRN complex relocalizes to nuclear foci
- ATM mediated response to DNA double-strand break
- Cellular Senescence
- Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
- Homologous Recombination Repair
- Recruitment of repair and signaling proteins to double-strand breaks
- Homologous recombination repair of replication-independent double-strand breaks
- Double-Strand Break Repair
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ND1 |
NADH dehydrogenase, subunit 1 (complex I) |
- Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
- Respiratory electron transport
- The citric acid (TCA) cycle and respiratory electron transport
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NPC2 |
Niemann-Pick disease, type C2 |
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PEX5 |
peroxisomal biogenesis factor 5 |
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PRPF3 |
pre-mRNA processing factor 3 |
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RBBP8 |
retinoblastoma binding protein 8 |
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RUNX1T1 |
runt-related transcription factor 1; translocated to, 1 (cyclin D-related) |
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SMAD2 |
SMAD family member 2 |
- Loss of Function of TGFBR2 in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- Downregulation of TGF-beta receptor signaling
- TGF-beta receptor signaling activates SMADs
- TGFBR1 LBD Mutants in Cancer
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- Generic Transcription Pathway
- Signaling by NODAL
- TGFBR2 MSI Frameshift Mutants in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Loss of Function of SMAD2/3 in Cancer
- Signaling by Activin
- TGFBR2 Kinase Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Signaling by TGF-beta Receptor Complex in Cancer
- Signaling by TGF-beta Receptor Complex
- SMAD4 MH2 Domain Mutants in Cancer
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SMC1A |
structural maintenance of chromosomes 1A |
- Establishment of Sister Chromatid Cohesion
- Processing of Capped Intron-Containing Pre-mRNA
- mRNA Splicing
- Mitotic Prometaphase
- Mitotic Telophase/Cytokinesis
- Separation of Sister Chromatids
- Meiotic synapsis
- Cohesin Loading onto Chromatin
- mRNA Splicing - Major Pathway
- Mitotic Anaphase
- S Phase
- M Phase
- Cell Cycle, Mitotic
- Resolution of Sister Chromatid Cohesion
- Mitotic Metaphase and Anaphase
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SNRNP200 |
small nuclear ribonucleoprotein 200kDa (U5) |
- Processing of Capped Intron-Containing Pre-mRNA
- mRNA Splicing
- mRNA Splicing - Minor Pathway
- mRNA Splicing - Major Pathway
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TSEN54 |
TSEN54 tRNA splicing endonuclease subunit |
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UBE3A |
ubiquitin protein ligase E3A |
- Antigen processing: Ubiquitination & Proteasome degradation
- Class I MHC mediated antigen processing & presentation
- Adaptive Immune System
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VCP |
valosin containing protein |
- HSF1 activation
- Hedgehog ligand biogenesis
- Processing-defective Hh variants abrogate ligand secretion
- Hh ligand biogenesis disease
- Signaling by Hedgehog
- Cellular response to heat stress
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XIAP |
X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase |
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- SMAC binds to IAPs
- SMAC-mediated dissociation of IAP:caspase complexes
- SMAC-mediated apoptotic response
- Signaling by Wnt
- deactivation of the beta-catenin transactivating complex
- Apoptotic factor-mediated response
- TCF dependent signaling in response to WNT
- RNF mutants show enhanced WNT signaling and proliferation
- Programmed Cell Death
- XAV939 inhibits tankyrase, stabilizing AXIN
- Signaling by WNT in cancer
- Intrinsic Pathway for Apoptosis
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- 1-[3,3-Dimethyl-2-(2-Methylamino-Propionylamino)-Butyryl]-Pyrrolidine-2-Carboxylic Acid(1,2,3,4-Tetrahydro-Naphthalen-1-Yl)-Amide
- N-METHYLALANYL-3-METHYLVALYL-4-PHENOXY-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE
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ZNF423 |
zinc finger protein 423 |
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