MYC and POLR2A |
v-myc avian myelocytomatosis viral oncogene homolog |
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa |
- Loss of Function of TGFBR2 in Cancer
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- Signaling by Wnt
- Cyclin E associated events during G1/S transition
- binding of TCF/LEF:CTNNB1 to target gene promoters
- TGFBR1 LBD Mutants in Cancer
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Generic Transcription Pathway
- RNF mutants show enhanced WNT signaling and proliferation
- G1/S Transition
- Signaling by NOTCH1
- XAV939 inhibits tankyrase, stabilizing AXIN
- Signaling by NOTCH1 in Cancer
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Mitotic G1-G1/S phases
- FBXW7 Mutants and NOTCH1 in Cancer
- TGFBR2 MSI Frameshift Mutants in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- Loss of Function of SMAD2/3 in Cancer
- Signaling by NOTCH
- formation of the beta-catenin:TCF transactivating complex
- TGFBR2 Kinase Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- S Phase
- Cell Cycle, Mitotic
- Loss of Function of TGFBR1 in Cancer
- NOTCH1 Intracellular Domain Regulates Transcription
- Signaling by TGF-beta Receptor Complex in Cancer
- Signaling by TGF-beta Receptor Complex
- TCF dependent signaling in response to WNT
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Cyclin A:Cdk2-associated events at S phase entry
- Signaling by WNT in cancer
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- SMAD4 MH2 Domain Mutants in Cancer
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- RNA Polymerase II Promoter Escape
- mRNA Splicing
- Formation of HIV-1 elongation complex containing HIV-1 Tat
- PIWI-interacting RNA (piRNA) biogenesis
- Nucleotide Excision Repair
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
- RNA Polymerase II Transcription
- Abortive elongation of HIV-1 transcript in the absence of Tat
- HIV Infection
- Regulatory RNA pathways
- Formation of the Early Elongation Complex
- Tat-mediated elongation of the HIV-1 transcript
- Tat-mediated HIV elongation arrest and recovery
- Formation of transcription-coupled NER (TC-NER) repair complex
- RNA Pol II CTD phosphorylation and interaction with CE
- RNA Polymerase II Pre-transcription Events
- Dual incision reaction in TC-NER
- Influenza Life Cycle
- HIV elongation arrest and recovery
- HIV Life Cycle
- HIV Transcription Initiation
- Influenza Viral RNA Transcription and Replication
- RNA Pol II CTD phosphorylation and interaction with CE
- Transcriptional regulation of pluripotent stem cells
- RNA Polymerase II HIV Promoter Escape
- HIV Transcription Elongation
- POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
- Transcriptional regulation by small RNAs
- Processing of Capped Intron-Containing Pre-mRNA
- mRNA Capping
- mRNA Splicing - Minor Pathway
- mRNA Splicing - Major Pathway
- MicroRNA (miRNA) biogenesis
- Influenza Infection
- Pausing and recovery of Tat-mediated HIV elongation
- Late Phase of HIV Life Cycle
- Formation of RNA Pol II elongation complex
- RNA Polymerase II Transcription Initiation And Promoter Clearance
- Pausing and recovery of HIV elongation
- Formation of HIV elongation complex in the absence of HIV Tat
- Transcription-coupled NER (TC-NER)
- Viral Messenger RNA Synthesis
- Formation of the HIV-1 Early Elongation Complex
- RNA Polymerase II Transcription Initiation
- Transcription of the HIV genome
- RNA Polymerase II Transcription Elongation
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MYC and PSMC3 |
v-myc avian myelocytomatosis viral oncogene homolog |
proteasome (prosome, macropain) 26S subunit, ATPase, 3 |
- Loss of Function of TGFBR2 in Cancer
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- Signaling by Wnt
- Cyclin E associated events during G1/S transition
- binding of TCF/LEF:CTNNB1 to target gene promoters
- TGFBR1 LBD Mutants in Cancer
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Generic Transcription Pathway
- RNF mutants show enhanced WNT signaling and proliferation
- G1/S Transition
- Signaling by NOTCH1
- XAV939 inhibits tankyrase, stabilizing AXIN
- Signaling by NOTCH1 in Cancer
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Mitotic G1-G1/S phases
- FBXW7 Mutants and NOTCH1 in Cancer
- TGFBR2 MSI Frameshift Mutants in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- Loss of Function of SMAD2/3 in Cancer
- Signaling by NOTCH
- formation of the beta-catenin:TCF transactivating complex
- TGFBR2 Kinase Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- S Phase
- Cell Cycle, Mitotic
- Loss of Function of TGFBR1 in Cancer
- NOTCH1 Intracellular Domain Regulates Transcription
- Signaling by TGF-beta Receptor Complex in Cancer
- Signaling by TGF-beta Receptor Complex
- TCF dependent signaling in response to WNT
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Cyclin A:Cdk2-associated events at S phase entry
- Signaling by WNT in cancer
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- SMAD4 MH2 Domain Mutants in Cancer
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- Hedgehog 'off' state
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- T41 mutants of beta-catenin aren't phosphorylated
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- Stabilization of p53
- S33 mutants of beta-catenin aren't phosphorylated
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Mitotic G1-G1/S phases
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- DNA Replication Pre-Initiation
- S45 mutants of beta-catenin aren't phosphorylated
- APC/C:Cdc20 mediated degradation of mitotic proteins
- Regulation of APC/C activators between G1/S and early anaphase
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Autodegradation of the E3 ubiquitin ligase COP1
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- PCP/CE pathway
- Adaptive Immune System
- CDK-mediated phosphorylation and removal of Cdc6
- Hedgehog ligand biogenesis
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Separation of Sister Chromatids
- HIV Infection
- Ubiquitin-dependent degradation of Cyclin D
- APC truncation mutants have impaired AXIN binding
- Assembly of the pre-replicative complex
- Autodegradation of Cdh1 by Cdh1:APC/C
- p53-Dependent G1 DNA Damage Response
- S37 mutants of beta-catenin aren't phosphorylated
- XAV939 inhibits tankyrase, stabilizing AXIN
- p53-Independent DNA Damage Response
- p53-Independent G1/S DNA damage checkpoint
- G1/S DNA Damage Checkpoints
- Vpu mediated degradation of CD4
- Synthesis of DNA
- M/G1 Transition
- Ubiquitin-dependent degradation of Cyclin D1
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Signaling by Hedgehog
- Regulation of mitotic cell cycle
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Cell Cycle Checkpoints
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- p53-Dependent G1/S DNA damage checkpoint
- truncated APC mutants destabilize the destruction complex
- TCF7L2 mutants don't bind CTBP
- Signaling by Wnt
- Cyclin E associated events during G1/S transition
- APC/C:Cdc20 mediated degradation of Securin
- AUF1 (hnRNP D0) destabilizes mRNA
- CDK-mediated phosphorylation and removal of Cdc6
- RNF mutants show enhanced WNT signaling and proliferation
- G1/S Transition
- truncations of AMER1 destabilize the destruction complex
- Processing-defective Hh variants abrogate ligand secretion
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Cyclin A:Cdk2-associated events at S phase entry
- SCF(Skp2)-mediated degradation of p27/p21
- Mitotic Metaphase and Anaphase
- Regulation of ornithine decarboxylase (ODC)
- Antigen processing: Ubiquitination & Proteasome degradation
- Orc1 removal from chromatin
- Mitotic Anaphase
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- Metabolism of amino acids and derivatives
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- Regulation of DNA replication
- Cell Cycle, Mitotic
- beta-catenin independent WNT signaling
- Orc1 removal from chromatin
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- Cross-presentation of soluble exogenous antigens (endosomes)
- Antigen processing-Cross presentation
- CDT1 association with the CDC6:ORC:origin complex
- ER-Phagosome pathway
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ERBB2 and NF2 |
erb-b2 receptor tyrosine kinase 2 |
neurofibromin 2 (merlin) |
- Signaling by the B Cell Receptor (BCR)
- Signaling by FGFR in disease
- Axon guidance
- PIP3 activates AKT signaling
- GRB7 events in ERBB2 signaling
- Signaling by EGFRvIII in Cancer
- PLCG1 events in ERBB2 signaling
- Signaling by SCF-KIT
- SHC1 events in ERBB2 signaling
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- PI3K/AKT activation
- PI-3K cascade
- GRB2 events in ERBB2 signaling
- PI3K events in ERBB2 signaling
- Downstream signaling of activated FGFR
- Sema4D in semaphorin signaling
- Sema4D induced cell migration and growth-cone collapse
- Innate Immune System
- Signaling by PDGF
- Downregulation of ERBB2:ERBB3 signaling
- Signalling by NGF
- DAP12 interactions
- GAB1 signalosome
- Semaphorin interactions
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Signaling by ERBB4
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- PI3K events in ERBB4 signaling
- Signaling by FGFR
- Signaling by ERBB2
- Signaling by EGFR
- Downstream signal transduction
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- PI3K/AKT Signaling in Cancer
- Adaptive Immune System
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- Trastuzumab
- Lapatinib
- ado-trastuzumab emtansine
- Pertuzumab
- Afatinib
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ERBB2 and UBB |
erb-b2 receptor tyrosine kinase 2 |
ubiquitin B |
- Signaling by the B Cell Receptor (BCR)
- Signaling by FGFR in disease
- Axon guidance
- PIP3 activates AKT signaling
- GRB7 events in ERBB2 signaling
- Signaling by EGFRvIII in Cancer
- PLCG1 events in ERBB2 signaling
- Signaling by SCF-KIT
- SHC1 events in ERBB2 signaling
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- PI3K/AKT activation
- PI-3K cascade
- GRB2 events in ERBB2 signaling
- PI3K events in ERBB2 signaling
- Downstream signaling of activated FGFR
- Sema4D in semaphorin signaling
- Sema4D induced cell migration and growth-cone collapse
- Innate Immune System
- Signaling by PDGF
- Downregulation of ERBB2:ERBB3 signaling
- Signalling by NGF
- DAP12 interactions
- GAB1 signalosome
- Semaphorin interactions
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Signaling by ERBB4
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- PI3K events in ERBB4 signaling
- Signaling by FGFR
- Signaling by ERBB2
- Signaling by EGFR
- Downstream signal transduction
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- PI3K/AKT Signaling in Cancer
- Adaptive Immune System
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- Loss of Function of TGFBR2 in Cancer
- NF-kB is activated and signals survival
- Signaling by FGFR in disease
- Hedgehog 'off' state
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Glucose metabolism
- Toll Like Receptor TLR1:TLR2 Cascade
- Signaling by NOTCH1
- Signaling by NOTCH2
- Toll Like Receptor 5 (TLR5) Cascade
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- S33 mutants of beta-catenin aren't phosphorylated
- Stabilization of p53
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Downregulation of ERBB2:ERBB3 signaling
- TGFBR2 MSI Frameshift Mutants in Cancer
- Signaling by NOTCH
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Spry regulation of FGF signaling
- Signaling by NOTCH
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Regulation of innate immune responses to cytosolic DNA
- Autodegradation of the E3 ubiquitin ligase COP1
- Toll Like Receptor 3 (TLR3) Cascade
- Metabolism of carbohydrates
- CDK-mediated phosphorylation and removal of Cdc6
- Cellular response to hypoxia
- Hedgehog ligand biogenesis
- p75NTR recruits signalling complexes
- Fanconi Anemia pathway
- Separation of Sister Chromatids
- HIV Infection
- APC truncation mutants have impaired AXIN binding
- Assembly of the pre-replicative complex
- Synthesis And Processing Of GAG, GAGPOL Polyproteins
- Activated TLR4 signalling
- S37 mutants of beta-catenin aren't phosphorylated
- p53-Dependent G1 DNA Damage Response
- regulation of FZD by ubiquitination
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1
- p53-Independent DNA Damage Response
- MyD88:Mal cascade initiated on plasma membrane
- Stimuli-sensing channels
- Membrane binding and targetting of GAG proteins
- p53-Independent G1/S DNA damage checkpoint
- G1/S DNA Damage Checkpoints
- Downregulation of ERBB4 signaling
- Vpu mediated degradation of CD4
- Cell death signalling via NRAGE, NRIF and NADE
- ISG15 antiviral mechanism
- Interferon Signaling
- M/G1 Transition
- p75 NTR receptor-mediated signalling
- Signaling by FGFR
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by NOTCH1 in Cancer
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Cell Cycle Checkpoints
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- Downregulation of TGF-beta receptor signaling
- truncated APC mutants destabilize the destruction complex
- Cyclin E associated events during G1/S transition
- TGF-beta receptor signaling activates SMADs
- Regulation of PLK1 Activity at G2/M Transition
- FCERI mediated NF-kB activation
- Regulation of the Fanconi anemia pathway
- Generic Transcription Pathway
- G1/S Transition
- Toll Like Receptor 9 (TLR9) Cascade
- FBXW7 Mutants and NOTCH1 in Cancer
- IRAK1 recruits IKK complex
- Negative regulation of FGFR signaling
- truncations of AMER1 destabilize the destruction complex
- EGFR downregulation
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- IRAK2 mediated activation of TAK1 complex
- Processing-defective Hh variants abrogate ligand secretion
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Signaling by ERBB4
- Antiviral mechanism by IFN-stimulated genes
- Fc epsilon receptor (FCERI) signaling
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Interleukin-3, 5 and GM-CSF signaling
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
- HIV Life Cycle
- Budding and maturation of HIV virion
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- IKK complex recruitment mediated by RIP1
- MAP kinase activation in TLR cascade
- Regulation of DNA replication
- Cytokine Signaling in Immune system
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- MyD88-independent cascade
- Cell Cycle, Mitotic
- Signaling by TGF-beta Receptor Complex in Cancer
- Oxidative Stress Induced Senescence
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
- TRAF6 mediated induction of TAK1 complex
- Negative regulators of RIG-I/MDA5 signaling
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- SMAD2/3 MH2 Domain Mutants in Cancer
- T41 mutants of beta-catenin aren't phosphorylated
- Cellular Senescence
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by EGFRvIII in Cancer
- Assembly Of The HIV Virion
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- NOD1/2 Signaling Pathway
- Glycogen storage diseases
- MyD88 dependent cascade initiated on endosome
- Mitotic G1-G1/S phases
- activated TAK1 mediates p38 MAPK activation
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TRIF-mediated TLR3/TLR4 signaling
- DNA Replication Pre-Initiation
- Senescence-Associated Secretory Phenotype (SASP)
- APC/C:Cdc20 mediated degradation of mitotic proteins
- TGFBR1 KD Mutants in Cancer
- S45 mutants of beta-catenin aren't phosphorylated
- Regulation of APC/C activators between G1/S and early anaphase
- Late Phase of HIV Life Cycle
- APC/C:Cdc20 mediated degradation of Cyclin B
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- TCR signaling
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- Interleukin-1 signaling
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- PCP/CE pathway
- Mitotic G2-G2/M phases
- Adaptive Immune System
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Regulation of Hypoxia-inducible Factor (HIF) by oxygen
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Ubiquitin-dependent degradation of Cyclin D
- G2/M Transition
- TGFBR1 LBD Mutants in Cancer
- Oncogene Induced Senescence
- Autodegradation of Cdh1 by Cdh1:APC/C
- Ion channel transport
- p75NTR signals via NF-kB
- Regulation of signaling by CBL
- XAV939 inhibits tankyrase, stabilizing AXIN
- Disease
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Signal Transduction
- Innate Immune System
- Synthesis of DNA
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- G1 Phase
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Ubiquitin-dependent degradation of Cyclin D1
- Activated NOTCH1 Transmits Signal to the Nucleus
- NOTCH1 Intracellular Domain Regulates Transcription
- Toll-Like Receptors Cascades
- Cyclin D associated events in G1
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Regulation of mitotic cell cycle
- Signaling by Hedgehog
- Association of licensing factors with the pre-replicative complex
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- TCF7L2 mutants don't bind CTBP
- p53-Dependent G1/S DNA damage checkpoint
- Signaling by Wnt
- AUF1 (hnRNP D0) destabilizes mRNA
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- APC/C:Cdc20 mediated degradation of Securin
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- IRAK1 recruits IKK complex
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- RNF mutants show enhanced WNT signaling and proliferation
- Myoclonic epilepsy of Lafora
- Signaling by NOTCH1 in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- IRAK2 mediated activation of TAK1 complex
- Loss of Function of SMAD4 in Cancer
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- Glycogen synthesis
- NRIF signals cell death from the nucleus
- Toll Like Receptor 4 (TLR4) Cascade
- Signaling by EGFR in Cancer
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- SCF(Skp2)-mediated degradation of p27/p21
- Cyclin A:Cdk2-associated events at S phase entry
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Mitotic Metaphase and Anaphase
- Downstream TCR signaling
- Antigen processing: Ubiquitination & Proteasome degradation
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Orc1 removal from chromatin
- Mitotic Anaphase
- deactivation of the beta-catenin transactivating complex
- Toll Like Receptor TLR6:TLR2 Cascade
- MyD88 cascade initiated on plasma membrane
- Activated NOTCH1 Transmits Signal to the Nucleus
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- Signalling by NGF
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Cytosolic sensors of pathogen-associated DNA
- beta-catenin independent WNT signaling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Orc1 removal from chromatin
- Signaling by TGF-beta Receptor Complex
- CDT1 association with the CDC6:ORC:origin complex
- Antigen processing-Cross presentation
- ER-Phagosome pathway
- SMAD4 MH2 Domain Mutants in Cancer
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- Trastuzumab
- Lapatinib
- ado-trastuzumab emtansine
- Pertuzumab
- Afatinib
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ERBB2 and HLA-A |
erb-b2 receptor tyrosine kinase 2 |
major histocompatibility complex, class I, A |
- Signaling by the B Cell Receptor (BCR)
- Signaling by FGFR in disease
- Axon guidance
- PIP3 activates AKT signaling
- GRB7 events in ERBB2 signaling
- Signaling by EGFRvIII in Cancer
- PLCG1 events in ERBB2 signaling
- Signaling by SCF-KIT
- SHC1 events in ERBB2 signaling
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- PI3K/AKT activation
- PI-3K cascade
- GRB2 events in ERBB2 signaling
- PI3K events in ERBB2 signaling
- Downstream signaling of activated FGFR
- Sema4D in semaphorin signaling
- Sema4D induced cell migration and growth-cone collapse
- Innate Immune System
- Signaling by PDGF
- Downregulation of ERBB2:ERBB3 signaling
- Signalling by NGF
- DAP12 interactions
- GAB1 signalosome
- Semaphorin interactions
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Signaling by ERBB4
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- PI3K events in ERBB4 signaling
- Signaling by FGFR
- Signaling by ERBB2
- Signaling by EGFR
- Downstream signal transduction
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- PI3K/AKT Signaling in Cancer
- Adaptive Immune System
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- Interferon gamma signaling
- Interferon Signaling
- Endosomal/Vacuolar pathway
- Cytokine Signaling in Immune system
- Interferon alpha/beta signaling
- Class I MHC mediated antigen processing & presentation
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
- Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
- Antigen processing-Cross presentation
- ER-Phagosome pathway
- Adaptive Immune System
- Interferon gamma signaling
- Interferon Signaling
- Endosomal/Vacuolar pathway
- Cytokine Signaling in Immune system
- Interferon alpha/beta signaling
- Class I MHC mediated antigen processing & presentation
- Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
- Antigen processing-Cross presentation
- ER-Phagosome pathway
- Adaptive Immune System
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- Trastuzumab
- Lapatinib
- ado-trastuzumab emtansine
- Pertuzumab
- Afatinib
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RB1 and TBP |
retinoblastoma 1 |
TATA box binding protein |
- E2F mediated regulation of DNA replication
- DNA Damage/Telomere Stress Induced Senescence
- Synthesis of DNA
- Mitotic Prophase
- Cellular Senescence
- G1 Phase
- Regulation of DNA replication
- Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
- Orc1 removal from chromatin
- S Phase
- Cyclin E associated events during G1/S transition
- Cell Cycle, Mitotic
- M Phase
- Orc1 removal from chromatin
- Cyclin D associated events in G1
- Formation of Senescence-Associated Heterochromatin Foci (SAHF)
- G1/S Transition
- Removal of licensing factors from origins
- Cyclin A:Cdk2-associated events at S phase entry
- Switching of origins to a post-replicative state
- Mitotic G1-G1/S phases
- Condensation of Prophase Chromosomes
- Inhibition of replication initiation of damaged DNA by RB1/E2F1
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- RNA Polymerase II Promoter Escape
- RNA Polymerase III Transcription Initiation From Type 3 Promoter
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
- RNA Polymerase I Chain Elongation
- RNA Polymerase II Transcription
- RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
- RNA Polymerase I Transcription Initiation
- RNA Polymerase I Promoter Clearance
- HIV Infection
- RNA Polymerase II Pre-transcription Events
- HIV Life Cycle
- HIV Transcription Initiation
- NoRC negatively regulates rRNA expression
- RNA Polymerase II HIV Promoter Escape
- RNA Polymerase III Transcription Initiation
- RNA Polymerase III Transcription
- RNA Polymerase III Transcription Initiation From Type 1 Promoter
- RNA Polymerase I Transcription
- RNA Polymerase I Transcription Termination
- RNA Polymerase I Promoter Escape
- Epigenetic regulation of gene expression
- Negative epigenetic regulation of rRNA expression
- Late Phase of HIV Life Cycle
- RNA Polymerase III Transcription Initiation From Type 2 Promoter
- RNA Polymerase II Transcription Initiation And Promoter Clearance
- RNA Polymerase III Abortive And Retractive Initiation
- RNA Polymerase II Transcription Initiation
- SIRT1 negatively regulates rRNA Expression
- Transcription of the HIV genome
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CCNT2 and RB1 |
cyclin T2 |
retinoblastoma 1 |
- Loss of Function of TGFBR2 in Cancer
- RNA Polymerase II Transcription
- HIV Infection
- SMAD2/3 MH2 Domain Mutants in Cancer
- TGFBR1 LBD Mutants in Cancer
- RNA Polymerase II Pre-transcription Events
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- HIV elongation arrest and recovery
- HIV Life Cycle
- Generic Transcription Pathway
- TGFBR2 MSI Frameshift Mutants in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Late Phase of HIV Life Cycle
- Formation of RNA Pol II elongation complex
- Signaling by TGF-beta Receptor Complex
- Signaling by TGF-beta Receptor Complex in Cancer
- Pausing and recovery of HIV elongation
- Formation of HIV elongation complex in the absence of HIV Tat
- Transcription of the HIV genome
- SMAD4 MH2 Domain Mutants in Cancer
- RNA Polymerase II Transcription Elongation
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- E2F mediated regulation of DNA replication
- DNA Damage/Telomere Stress Induced Senescence
- Synthesis of DNA
- Mitotic Prophase
- Cellular Senescence
- G1 Phase
- Regulation of DNA replication
- Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
- Orc1 removal from chromatin
- S Phase
- Cyclin E associated events during G1/S transition
- Cell Cycle, Mitotic
- M Phase
- Orc1 removal from chromatin
- Cyclin D associated events in G1
- Formation of Senescence-Associated Heterochromatin Foci (SAHF)
- G1/S Transition
- Removal of licensing factors from origins
- Cyclin A:Cdk2-associated events at S phase entry
- Switching of origins to a post-replicative state
- Mitotic G1-G1/S phases
- Condensation of Prophase Chromosomes
- Inhibition of replication initiation of damaged DNA by RB1/E2F1
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CD4 and HLA-DQB1 |
CD4 molecule |
major histocompatibility complex, class II, DQ beta 1 |
- Vpu mediated degradation of CD4
- Downstream TCR signaling
- Generation of second messenger molecules
- Translocation of ZAP-70 to Immunological synapse
- Costimulation by the CD28 family
- Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
- HIV Infection
- Host Interactions of HIV factors
- The role of Nef in HIV-1 replication and disease pathogenesis
- Early Phase of HIV Life Cycle
- HIV Life Cycle
- TCR signaling
- Alpha-defensins
- PD-1 signaling
- Defensins
- Phosphorylation of CD3 and TCR zeta chains
- Nef Mediated CD4 Down-regulation
- Binding and entry of HIV virion
- Innate Immune System
- Adaptive Immune System
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- Generation of second messenger molecules
- Downstream TCR signaling
- Costimulation by the CD28 family
- Translocation of ZAP-70 to Immunological synapse
- Interferon Signaling
- Cytokine Signaling in Immune system
- Interferon gamma signaling
- TCR signaling
- MHC class II antigen presentation
- PD-1 signaling
- Phosphorylation of CD3 and TCR zeta chains
- Adaptive Immune System
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CDK9 and RB1 |
cyclin-dependent kinase 9 |
retinoblastoma 1 |
- Loss of Function of TGFBR2 in Cancer
- Formation of HIV-1 elongation complex containing HIV-1 Tat
- RNA Polymerase II Transcription
- HIV Infection
- SMAD2/3 MH2 Domain Mutants in Cancer
- Tat-mediated elongation of the HIV-1 transcript
- Tat-mediated HIV elongation arrest and recovery
- TGFBR1 LBD Mutants in Cancer
- RNA Polymerase II Pre-transcription Events
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- HIV elongation arrest and recovery
- HIV Life Cycle
- Generic Transcription Pathway
- HIV Transcription Elongation
- TGFBR2 MSI Frameshift Mutants in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- Host Interactions of HIV factors
- Loss of Function of SMAD4 in Cancer
- Interactions of Tat with host cellular proteins
- TGFBR1 KD Mutants in Cancer
- Pausing and recovery of Tat-mediated HIV elongation
- Loss of Function of TGFBR1 in Cancer
- Late Phase of HIV Life Cycle
- Formation of RNA Pol II elongation complex
- Signaling by TGF-beta Receptor Complex
- Signaling by TGF-beta Receptor Complex in Cancer
- Pausing and recovery of HIV elongation
- Formation of HIV elongation complex in the absence of HIV Tat
- Transcription of the HIV genome
- SMAD4 MH2 Domain Mutants in Cancer
- RNA Polymerase II Transcription Elongation
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- E2F mediated regulation of DNA replication
- DNA Damage/Telomere Stress Induced Senescence
- Synthesis of DNA
- Mitotic Prophase
- Cellular Senescence
- G1 Phase
- Regulation of DNA replication
- Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
- Orc1 removal from chromatin
- S Phase
- Cyclin E associated events during G1/S transition
- Cell Cycle, Mitotic
- M Phase
- Orc1 removal from chromatin
- Cyclin D associated events in G1
- Formation of Senescence-Associated Heterochromatin Foci (SAHF)
- G1/S Transition
- Removal of licensing factors from origins
- Cyclin A:Cdk2-associated events at S phase entry
- Switching of origins to a post-replicative state
- Mitotic G1-G1/S phases
- Condensation of Prophase Chromosomes
- Inhibition of replication initiation of damaged DNA by RB1/E2F1
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DYRK1A and RB1 |
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A |
retinoblastoma 1 |
- G0 and Early G1
- Mitotic G1-G1/S phases
- Cell Cycle, Mitotic
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- E2F mediated regulation of DNA replication
- DNA Damage/Telomere Stress Induced Senescence
- Synthesis of DNA
- Mitotic Prophase
- Cellular Senescence
- G1 Phase
- Regulation of DNA replication
- Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
- Orc1 removal from chromatin
- S Phase
- Cyclin E associated events during G1/S transition
- Cell Cycle, Mitotic
- M Phase
- Orc1 removal from chromatin
- Cyclin D associated events in G1
- Formation of Senescence-Associated Heterochromatin Foci (SAHF)
- G1/S Transition
- Removal of licensing factors from origins
- Cyclin A:Cdk2-associated events at S phase entry
- Switching of origins to a post-replicative state
- Mitotic G1-G1/S phases
- Condensation of Prophase Chromosomes
- Inhibition of replication initiation of damaged DNA by RB1/E2F1
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EGFR and CMTM8 |
epidermal growth factor receptor |
CKLF-like MARVEL transmembrane domain containing 8 |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- PLCG1 events in ERBB2 signaling
- SHC1 events in ERBB2 signaling
- Signaling by SCF-KIT
- DAP12 signaling
- Downstream signaling events of B Cell Receptor (BCR)
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- PI3K/AKT activation
- PI-3K cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- Signaling by PDGF
- EGFR downregulation
- DAP12 interactions
- GAB1 signalosome
- GRB2 events in EGFR signaling
- Signaling by ERBB4
- Constitutive PI3K/AKT Signaling in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- PI3K events in ERBB4 signaling
- EGFR interacts with phospholipase C-gamma
- Signaling by ERBB2
- Signaling by EGFR
- Downstream signal transduction
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- PI3K/AKT Signaling in Cancer
- Adaptive Immune System
- Axon guidance
- PIP3 activates AKT signaling
- L1CAM interactions
- EGFR Transactivation by Gastrin
- GRB2 events in ERBB2 signaling
- PI3K events in ERBB2 signaling
- Downstream signaling of activated FGFR
- Innate Immune System
- Signalling by NGF
- Signal transduction by L1
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Inhibition of Signaling by Overexpressed EGFR
- Signaling by FGFR
- SHC1 events in EGFR signaling
- Constitutive Signaling by EGFRvIII
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- Cetuximab
- Trastuzumab
- Lidocaine
- Gefitinib
- Erlotinib
- Lapatinib
- Panitumumab
- Flavopiridol
- Vandetanib
- S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE
- N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE
- Afatinib
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EGFR and XRCC6 |
epidermal growth factor receptor |
X-ray repair complementing defective repair in Chinese hamster cells 6 |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- PLCG1 events in ERBB2 signaling
- SHC1 events in ERBB2 signaling
- Signaling by SCF-KIT
- DAP12 signaling
- Downstream signaling events of B Cell Receptor (BCR)
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- PI3K/AKT activation
- PI-3K cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- Signaling by PDGF
- EGFR downregulation
- DAP12 interactions
- GAB1 signalosome
- GRB2 events in EGFR signaling
- Signaling by ERBB4
- Constitutive PI3K/AKT Signaling in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- PI3K events in ERBB4 signaling
- EGFR interacts with phospholipase C-gamma
- Signaling by ERBB2
- Signaling by EGFR
- Downstream signal transduction
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- PI3K/AKT Signaling in Cancer
- Adaptive Immune System
- Axon guidance
- PIP3 activates AKT signaling
- L1CAM interactions
- EGFR Transactivation by Gastrin
- GRB2 events in ERBB2 signaling
- PI3K events in ERBB2 signaling
- Downstream signaling of activated FGFR
- Innate Immune System
- Signalling by NGF
- Signal transduction by L1
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Inhibition of Signaling by Overexpressed EGFR
- Signaling by FGFR
- SHC1 events in EGFR signaling
- Constitutive Signaling by EGFRvIII
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- Cytosolic sensors of pathogen-associated DNA
- HIV Infection
- Processing of DNA ends prior to end rejoining
- Integration of provirus
- Early Phase of HIV Life Cycle
- HIV Life Cycle
- Nonhomologous End-joining (NHEJ)
- STING mediated induction of host immune responses
- Double-Strand Break Repair
- IRF3-mediated induction of type I IFN
- 2-LTR circle formation
- Innate Immune System
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- Cetuximab
- Trastuzumab
- Lidocaine
- Gefitinib
- Erlotinib
- Lapatinib
- Panitumumab
- Flavopiridol
- Vandetanib
- S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE
- N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE
- Afatinib
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EGFR and UBB |
epidermal growth factor receptor |
ubiquitin B |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- PLCG1 events in ERBB2 signaling
- SHC1 events in ERBB2 signaling
- Signaling by SCF-KIT
- DAP12 signaling
- Downstream signaling events of B Cell Receptor (BCR)
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- PI3K/AKT activation
- PI-3K cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- Signaling by PDGF
- EGFR downregulation
- DAP12 interactions
- GAB1 signalosome
- GRB2 events in EGFR signaling
- Signaling by ERBB4
- Constitutive PI3K/AKT Signaling in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- PI3K events in ERBB4 signaling
- EGFR interacts with phospholipase C-gamma
- Signaling by ERBB2
- Signaling by EGFR
- Downstream signal transduction
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- PI3K/AKT Signaling in Cancer
- Adaptive Immune System
- Axon guidance
- PIP3 activates AKT signaling
- L1CAM interactions
- EGFR Transactivation by Gastrin
- GRB2 events in ERBB2 signaling
- PI3K events in ERBB2 signaling
- Downstream signaling of activated FGFR
- Innate Immune System
- Signalling by NGF
- Signal transduction by L1
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Inhibition of Signaling by Overexpressed EGFR
- Signaling by FGFR
- SHC1 events in EGFR signaling
- Constitutive Signaling by EGFRvIII
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- Loss of Function of TGFBR2 in Cancer
- NF-kB is activated and signals survival
- Signaling by FGFR in disease
- Hedgehog 'off' state
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Glucose metabolism
- Toll Like Receptor TLR1:TLR2 Cascade
- Signaling by NOTCH1
- Signaling by NOTCH2
- Toll Like Receptor 5 (TLR5) Cascade
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- S33 mutants of beta-catenin aren't phosphorylated
- Stabilization of p53
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Downregulation of ERBB2:ERBB3 signaling
- TGFBR2 MSI Frameshift Mutants in Cancer
- Signaling by NOTCH
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Spry regulation of FGF signaling
- Signaling by NOTCH
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Regulation of innate immune responses to cytosolic DNA
- Autodegradation of the E3 ubiquitin ligase COP1
- Toll Like Receptor 3 (TLR3) Cascade
- Metabolism of carbohydrates
- CDK-mediated phosphorylation and removal of Cdc6
- Cellular response to hypoxia
- Hedgehog ligand biogenesis
- p75NTR recruits signalling complexes
- Fanconi Anemia pathway
- Separation of Sister Chromatids
- HIV Infection
- APC truncation mutants have impaired AXIN binding
- Assembly of the pre-replicative complex
- Synthesis And Processing Of GAG, GAGPOL Polyproteins
- Activated TLR4 signalling
- S37 mutants of beta-catenin aren't phosphorylated
- p53-Dependent G1 DNA Damage Response
- regulation of FZD by ubiquitination
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1
- p53-Independent DNA Damage Response
- MyD88:Mal cascade initiated on plasma membrane
- Stimuli-sensing channels
- Membrane binding and targetting of GAG proteins
- p53-Independent G1/S DNA damage checkpoint
- G1/S DNA Damage Checkpoints
- Downregulation of ERBB4 signaling
- Vpu mediated degradation of CD4
- Cell death signalling via NRAGE, NRIF and NADE
- ISG15 antiviral mechanism
- Interferon Signaling
- M/G1 Transition
- p75 NTR receptor-mediated signalling
- Signaling by FGFR
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by NOTCH1 in Cancer
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Cell Cycle Checkpoints
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- Downregulation of TGF-beta receptor signaling
- truncated APC mutants destabilize the destruction complex
- Cyclin E associated events during G1/S transition
- TGF-beta receptor signaling activates SMADs
- Regulation of PLK1 Activity at G2/M Transition
- FCERI mediated NF-kB activation
- Regulation of the Fanconi anemia pathway
- Generic Transcription Pathway
- G1/S Transition
- Toll Like Receptor 9 (TLR9) Cascade
- FBXW7 Mutants and NOTCH1 in Cancer
- IRAK1 recruits IKK complex
- Negative regulation of FGFR signaling
- truncations of AMER1 destabilize the destruction complex
- EGFR downregulation
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- IRAK2 mediated activation of TAK1 complex
- Processing-defective Hh variants abrogate ligand secretion
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Signaling by ERBB4
- Antiviral mechanism by IFN-stimulated genes
- Fc epsilon receptor (FCERI) signaling
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Interleukin-3, 5 and GM-CSF signaling
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
- HIV Life Cycle
- Budding and maturation of HIV virion
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- IKK complex recruitment mediated by RIP1
- MAP kinase activation in TLR cascade
- Regulation of DNA replication
- Cytokine Signaling in Immune system
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- MyD88-independent cascade
- Cell Cycle, Mitotic
- Signaling by TGF-beta Receptor Complex in Cancer
- Oxidative Stress Induced Senescence
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
- TRAF6 mediated induction of TAK1 complex
- Negative regulators of RIG-I/MDA5 signaling
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- SMAD2/3 MH2 Domain Mutants in Cancer
- T41 mutants of beta-catenin aren't phosphorylated
- Cellular Senescence
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by EGFRvIII in Cancer
- Assembly Of The HIV Virion
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- NOD1/2 Signaling Pathway
- Glycogen storage diseases
- MyD88 dependent cascade initiated on endosome
- Mitotic G1-G1/S phases
- activated TAK1 mediates p38 MAPK activation
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TRIF-mediated TLR3/TLR4 signaling
- DNA Replication Pre-Initiation
- Senescence-Associated Secretory Phenotype (SASP)
- APC/C:Cdc20 mediated degradation of mitotic proteins
- TGFBR1 KD Mutants in Cancer
- S45 mutants of beta-catenin aren't phosphorylated
- Regulation of APC/C activators between G1/S and early anaphase
- Late Phase of HIV Life Cycle
- APC/C:Cdc20 mediated degradation of Cyclin B
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- TCR signaling
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- Interleukin-1 signaling
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- PCP/CE pathway
- Mitotic G2-G2/M phases
- Adaptive Immune System
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Regulation of Hypoxia-inducible Factor (HIF) by oxygen
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Ubiquitin-dependent degradation of Cyclin D
- G2/M Transition
- TGFBR1 LBD Mutants in Cancer
- Oncogene Induced Senescence
- Autodegradation of Cdh1 by Cdh1:APC/C
- Ion channel transport
- p75NTR signals via NF-kB
- Regulation of signaling by CBL
- XAV939 inhibits tankyrase, stabilizing AXIN
- Disease
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Signal Transduction
- Innate Immune System
- Synthesis of DNA
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- G1 Phase
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Ubiquitin-dependent degradation of Cyclin D1
- Activated NOTCH1 Transmits Signal to the Nucleus
- NOTCH1 Intracellular Domain Regulates Transcription
- Toll-Like Receptors Cascades
- Cyclin D associated events in G1
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Regulation of mitotic cell cycle
- Signaling by Hedgehog
- Association of licensing factors with the pre-replicative complex
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- TCF7L2 mutants don't bind CTBP
- p53-Dependent G1/S DNA damage checkpoint
- Signaling by Wnt
- AUF1 (hnRNP D0) destabilizes mRNA
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- APC/C:Cdc20 mediated degradation of Securin
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- IRAK1 recruits IKK complex
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- RNF mutants show enhanced WNT signaling and proliferation
- Myoclonic epilepsy of Lafora
- Signaling by NOTCH1 in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- IRAK2 mediated activation of TAK1 complex
- Loss of Function of SMAD4 in Cancer
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- Glycogen synthesis
- NRIF signals cell death from the nucleus
- Toll Like Receptor 4 (TLR4) Cascade
- Signaling by EGFR in Cancer
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- SCF(Skp2)-mediated degradation of p27/p21
- Cyclin A:Cdk2-associated events at S phase entry
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Mitotic Metaphase and Anaphase
- Downstream TCR signaling
- Antigen processing: Ubiquitination & Proteasome degradation
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Orc1 removal from chromatin
- Mitotic Anaphase
- deactivation of the beta-catenin transactivating complex
- Toll Like Receptor TLR6:TLR2 Cascade
- MyD88 cascade initiated on plasma membrane
- Activated NOTCH1 Transmits Signal to the Nucleus
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- Signalling by NGF
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Cytosolic sensors of pathogen-associated DNA
- beta-catenin independent WNT signaling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Orc1 removal from chromatin
- Signaling by TGF-beta Receptor Complex
- CDT1 association with the CDC6:ORC:origin complex
- Antigen processing-Cross presentation
- ER-Phagosome pathway
- SMAD4 MH2 Domain Mutants in Cancer
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- Cetuximab
- Trastuzumab
- Lidocaine
- Gefitinib
- Erlotinib
- Lapatinib
- Panitumumab
- Flavopiridol
- Vandetanib
- S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE
- N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE
- Afatinib
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EGFR and PSMA7 |
epidermal growth factor receptor |
proteasome (prosome, macropain) subunit, alpha type, 7 |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- PLCG1 events in ERBB2 signaling
- SHC1 events in ERBB2 signaling
- Signaling by SCF-KIT
- DAP12 signaling
- Downstream signaling events of B Cell Receptor (BCR)
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- PI3K/AKT activation
- PI-3K cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- Signaling by PDGF
- EGFR downregulation
- DAP12 interactions
- GAB1 signalosome
- GRB2 events in EGFR signaling
- Signaling by ERBB4
- Constitutive PI3K/AKT Signaling in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- PI3K events in ERBB4 signaling
- EGFR interacts with phospholipase C-gamma
- Signaling by ERBB2
- Signaling by EGFR
- Downstream signal transduction
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- PI3K/AKT Signaling in Cancer
- Adaptive Immune System
- Axon guidance
- PIP3 activates AKT signaling
- L1CAM interactions
- EGFR Transactivation by Gastrin
- GRB2 events in ERBB2 signaling
- PI3K events in ERBB2 signaling
- Downstream signaling of activated FGFR
- Innate Immune System
- Signalling by NGF
- Signal transduction by L1
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Inhibition of Signaling by Overexpressed EGFR
- Signaling by FGFR
- SHC1 events in EGFR signaling
- Constitutive Signaling by EGFRvIII
|
- Hedgehog 'off' state
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- T41 mutants of beta-catenin aren't phosphorylated
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- Stabilization of p53
- S33 mutants of beta-catenin aren't phosphorylated
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Mitotic G1-G1/S phases
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- DNA Replication Pre-Initiation
- S45 mutants of beta-catenin aren't phosphorylated
- APC/C:Cdc20 mediated degradation of mitotic proteins
- Regulation of APC/C activators between G1/S and early anaphase
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Autodegradation of the E3 ubiquitin ligase COP1
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- PCP/CE pathway
- Adaptive Immune System
- CDK-mediated phosphorylation and removal of Cdc6
- Hedgehog ligand biogenesis
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Separation of Sister Chromatids
- HIV Infection
- Ubiquitin-dependent degradation of Cyclin D
- APC truncation mutants have impaired AXIN binding
- Assembly of the pre-replicative complex
- Autodegradation of Cdh1 by Cdh1:APC/C
- p53-Dependent G1 DNA Damage Response
- S37 mutants of beta-catenin aren't phosphorylated
- XAV939 inhibits tankyrase, stabilizing AXIN
- p53-Independent DNA Damage Response
- p53-Independent G1/S DNA damage checkpoint
- G1/S DNA Damage Checkpoints
- Vpu mediated degradation of CD4
- Synthesis of DNA
- M/G1 Transition
- Ubiquitin-dependent degradation of Cyclin D1
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Signaling by Hedgehog
- Regulation of mitotic cell cycle
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Cell Cycle Checkpoints
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- p53-Dependent G1/S DNA damage checkpoint
- truncated APC mutants destabilize the destruction complex
- TCF7L2 mutants don't bind CTBP
- Signaling by Wnt
- Cyclin E associated events during G1/S transition
- APC/C:Cdc20 mediated degradation of Securin
- AUF1 (hnRNP D0) destabilizes mRNA
- CDK-mediated phosphorylation and removal of Cdc6
- RNF mutants show enhanced WNT signaling and proliferation
- G1/S Transition
- truncations of AMER1 destabilize the destruction complex
- Processing-defective Hh variants abrogate ligand secretion
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Cyclin A:Cdk2-associated events at S phase entry
- SCF(Skp2)-mediated degradation of p27/p21
- Mitotic Metaphase and Anaphase
- Regulation of ornithine decarboxylase (ODC)
- Antigen processing: Ubiquitination & Proteasome degradation
- Orc1 removal from chromatin
- Mitotic Anaphase
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- Metabolism of amino acids and derivatives
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- Regulation of DNA replication
- Cell Cycle, Mitotic
- beta-catenin independent WNT signaling
- Orc1 removal from chromatin
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- Cross-presentation of soluble exogenous antigens (endosomes)
- Antigen processing-Cross presentation
- CDT1 association with the CDC6:ORC:origin complex
- ER-Phagosome pathway
|
- Cetuximab
- Trastuzumab
- Lidocaine
- Gefitinib
- Erlotinib
- Lapatinib
- Panitumumab
- Flavopiridol
- Vandetanib
- S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE
- N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE
- Afatinib
|
|
|
|
EGFR and PSMD4 |
epidermal growth factor receptor |
proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- PLCG1 events in ERBB2 signaling
- SHC1 events in ERBB2 signaling
- Signaling by SCF-KIT
- DAP12 signaling
- Downstream signaling events of B Cell Receptor (BCR)
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- PI3K/AKT activation
- PI-3K cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- Signaling by PDGF
- EGFR downregulation
- DAP12 interactions
- GAB1 signalosome
- GRB2 events in EGFR signaling
- Signaling by ERBB4
- Constitutive PI3K/AKT Signaling in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- PI3K events in ERBB4 signaling
- EGFR interacts with phospholipase C-gamma
- Signaling by ERBB2
- Signaling by EGFR
- Downstream signal transduction
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- PI3K/AKT Signaling in Cancer
- Adaptive Immune System
- Axon guidance
- PIP3 activates AKT signaling
- L1CAM interactions
- EGFR Transactivation by Gastrin
- GRB2 events in ERBB2 signaling
- PI3K events in ERBB2 signaling
- Downstream signaling of activated FGFR
- Innate Immune System
- Signalling by NGF
- Signal transduction by L1
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Inhibition of Signaling by Overexpressed EGFR
- Signaling by FGFR
- SHC1 events in EGFR signaling
- Constitutive Signaling by EGFRvIII
|
- Hedgehog 'off' state
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- T41 mutants of beta-catenin aren't phosphorylated
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- Stabilization of p53
- S33 mutants of beta-catenin aren't phosphorylated
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Mitotic G1-G1/S phases
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- DNA Replication Pre-Initiation
- S45 mutants of beta-catenin aren't phosphorylated
- APC/C:Cdc20 mediated degradation of mitotic proteins
- Regulation of APC/C activators between G1/S and early anaphase
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Autodegradation of the E3 ubiquitin ligase COP1
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- PCP/CE pathway
- Adaptive Immune System
- CDK-mediated phosphorylation and removal of Cdc6
- Hedgehog ligand biogenesis
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Separation of Sister Chromatids
- HIV Infection
- Ubiquitin-dependent degradation of Cyclin D
- APC truncation mutants have impaired AXIN binding
- Assembly of the pre-replicative complex
- Autodegradation of Cdh1 by Cdh1:APC/C
- p53-Dependent G1 DNA Damage Response
- S37 mutants of beta-catenin aren't phosphorylated
- XAV939 inhibits tankyrase, stabilizing AXIN
- p53-Independent DNA Damage Response
- p53-Independent G1/S DNA damage checkpoint
- G1/S DNA Damage Checkpoints
- Vpu mediated degradation of CD4
- Synthesis of DNA
- M/G1 Transition
- Ubiquitin-dependent degradation of Cyclin D1
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Signaling by Hedgehog
- Regulation of mitotic cell cycle
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Cell Cycle Checkpoints
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- p53-Dependent G1/S DNA damage checkpoint
- truncated APC mutants destabilize the destruction complex
- TCF7L2 mutants don't bind CTBP
- Signaling by Wnt
- Cyclin E associated events during G1/S transition
- APC/C:Cdc20 mediated degradation of Securin
- AUF1 (hnRNP D0) destabilizes mRNA
- CDK-mediated phosphorylation and removal of Cdc6
- RNF mutants show enhanced WNT signaling and proliferation
- G1/S Transition
- truncations of AMER1 destabilize the destruction complex
- Processing-defective Hh variants abrogate ligand secretion
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Cyclin A:Cdk2-associated events at S phase entry
- SCF(Skp2)-mediated degradation of p27/p21
- Mitotic Metaphase and Anaphase
- Regulation of ornithine decarboxylase (ODC)
- Antigen processing: Ubiquitination & Proteasome degradation
- Orc1 removal from chromatin
- Mitotic Anaphase
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- Metabolism of amino acids and derivatives
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- Regulation of DNA replication
- Cell Cycle, Mitotic
- beta-catenin independent WNT signaling
- Orc1 removal from chromatin
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- Cross-presentation of soluble exogenous antigens (endosomes)
- Antigen processing-Cross presentation
- CDT1 association with the CDC6:ORC:origin complex
- ER-Phagosome pathway
|
- Cetuximab
- Trastuzumab
- Lidocaine
- Gefitinib
- Erlotinib
- Lapatinib
- Panitumumab
- Flavopiridol
- Vandetanib
- S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE
- N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE
- Afatinib
|
|
|
|
EGFR and PDCD6IP |
epidermal growth factor receptor |
programmed cell death 6 interacting protein |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- PLCG1 events in ERBB2 signaling
- SHC1 events in ERBB2 signaling
- Signaling by SCF-KIT
- DAP12 signaling
- Downstream signaling events of B Cell Receptor (BCR)
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- PI3K/AKT activation
- PI-3K cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- Signaling by PDGF
- EGFR downregulation
- DAP12 interactions
- GAB1 signalosome
- GRB2 events in EGFR signaling
- Signaling by ERBB4
- Constitutive PI3K/AKT Signaling in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- PI3K events in ERBB4 signaling
- EGFR interacts with phospholipase C-gamma
- Signaling by ERBB2
- Signaling by EGFR
- Downstream signal transduction
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- PI3K/AKT Signaling in Cancer
- Adaptive Immune System
- Axon guidance
- PIP3 activates AKT signaling
- L1CAM interactions
- EGFR Transactivation by Gastrin
- GRB2 events in ERBB2 signaling
- PI3K events in ERBB2 signaling
- Downstream signaling of activated FGFR
- Innate Immune System
- Signalling by NGF
- Signal transduction by L1
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Inhibition of Signaling by Overexpressed EGFR
- Signaling by FGFR
- SHC1 events in EGFR signaling
- Constitutive Signaling by EGFRvIII
|
- HIV Life Cycle
- Budding and maturation of HIV virion
- Uptake and actions of bacterial toxins
- HIV Infection
- Uptake and function of anthrax toxins
- Late Phase of HIV Life Cycle
|
- Cetuximab
- Trastuzumab
- Lidocaine
- Gefitinib
- Erlotinib
- Lapatinib
- Panitumumab
- Flavopiridol
- Vandetanib
- S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE
- N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE
- Afatinib
|
|
|
|
MNAT1 and RB1 |
MNAT CDK-activating kinase assembly factor 1 |
retinoblastoma 1 |
- RNA Polymerase II Promoter Escape
- Formation of HIV-1 elongation complex containing HIV-1 Tat
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
- RNA Polymerase I Chain Elongation
- RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
- Tat-mediated elongation of the HIV-1 transcript
- Cyclin E associated events during G1/S transition
- Formation of transcription-coupled NER (TC-NER) repair complex
- Dual incision reaction in TC-NER
- NoRC negatively regulates rRNA expression
- G1/S Transition
- Mitotic G1-G1/S phases
- S Phase
- Late Phase of HIV Life Cycle
- Formation of RNA Pol II elongation complex
- Global Genomic NER (GG-NER)
- RNA Polymerase II Transcription Initiation And Promoter Clearance
- Cyclin A:Cdk2-associated events at S phase entry
- Mitotic G2-G2/M phases
- Transcription of the HIV genome
- Nucleotide Excision Repair
- RNA Polymerase II Transcription
- RNA Polymerase I Transcription Initiation
- HIV Infection
- RNA Polymerase I Promoter Clearance
- Formation of the Early Elongation Complex
- G2/M Transition
- RNA Pol II CTD phosphorylation and interaction with CE
- RNA Polymerase II Pre-transcription Events
- HIV Transcription Initiation
- HIV Life Cycle
- RNA Pol II CTD phosphorylation and interaction with CE
- Cyclin A/B1 associated events during G2/M transition
- RNA Polymerase II HIV Promoter Escape
- HIV Transcription Elongation
- Dual incision reaction in GG-NER
- RNA Polymerase I Transcription
- mRNA Capping
- RNA Polymerase I Promoter Escape
- RNA Polymerase I Transcription Termination
- G1 Phase
- Epigenetic regulation of gene expression
- Negative epigenetic regulation of rRNA expression
- Cell Cycle, Mitotic
- Cyclin D associated events in G1
- Transcription-coupled NER (TC-NER)
- Formation of HIV elongation complex in the absence of HIV Tat
- Formation of the HIV-1 Early Elongation Complex
- Formation of incision complex in GG-NER
- RNA Polymerase II Transcription Initiation
- RNA Polymerase II Transcription Elongation
|
- E2F mediated regulation of DNA replication
- DNA Damage/Telomere Stress Induced Senescence
- Synthesis of DNA
- Mitotic Prophase
- Cellular Senescence
- G1 Phase
- Regulation of DNA replication
- Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
- Orc1 removal from chromatin
- S Phase
- Cyclin E associated events during G1/S transition
- Cell Cycle, Mitotic
- M Phase
- Orc1 removal from chromatin
- Cyclin D associated events in G1
- Formation of Senescence-Associated Heterochromatin Foci (SAHF)
- G1/S Transition
- Removal of licensing factors from origins
- Cyclin A:Cdk2-associated events at S phase entry
- Switching of origins to a post-replicative state
- Mitotic G1-G1/S phases
- Condensation of Prophase Chromosomes
- Inhibition of replication initiation of damaged DNA by RB1/E2F1
|
|
|
|
|
PPIA and RB1 |
peptidylprolyl isomerase A (cyclophilin A) |
retinoblastoma 1 |
- HIV Infection
- Host Interactions of HIV factors
- Integration of provirus
- Platelet degranulation
- Basigin interactions
- Late Phase of HIV Life Cycle
- Cell surface interactions at the vascular wall
- Uncoating of the HIV Virion
- Early Phase of HIV Life Cycle
- Reverse Transcription of HIV RNA
- Assembly Of The HIV Virion
- HIV Life Cycle
- Budding and maturation of HIV virion
- Response to elevated platelet cytosolic Ca2+
- Minus-strand DNA synthesis
- Platelet activation, signaling and aggregation
- Binding and entry of HIV virion
- Plus-strand DNA synthesis
- APOBEC3G mediated resistance to HIV-1 infection
|
- E2F mediated regulation of DNA replication
- DNA Damage/Telomere Stress Induced Senescence
- Synthesis of DNA
- Mitotic Prophase
- Cellular Senescence
- G1 Phase
- Regulation of DNA replication
- Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
- Orc1 removal from chromatin
- S Phase
- Cyclin E associated events during G1/S transition
- Cell Cycle, Mitotic
- M Phase
- Orc1 removal from chromatin
- Cyclin D associated events in G1
- Formation of Senescence-Associated Heterochromatin Foci (SAHF)
- G1/S Transition
- Removal of licensing factors from origins
- Cyclin A:Cdk2-associated events at S phase entry
- Switching of origins to a post-replicative state
- Mitotic G1-G1/S phases
- Condensation of Prophase Chromosomes
- Inhibition of replication initiation of damaged DNA by RB1/E2F1
|
- Cyclosporine
- L-Proline
- (3r)-1-Acetyl-3-Methylpiperidine
- Ethyl Oxo(Piperidin-1-Yl)Acetate
- (3s,6s,9r,10r,11s,12s,13e,15e,18s,21s)-18-{(1e,3e,7s,8s)-9-[(2s,3r,4s,5s,6r,9s,11s)-9-Ethyl-4-Hydroxy-3,5,11-Trimethyl-8-Oxo-1-Oxa-7-Azaspiro[5.5]Undec-2-Yl]-8-Hydroxy-1,7-Dimethylnona-1,3-Dienyl}-10,12-Dihydroxy-3-(3-Hydroxybenzyl)-6-Isopropyl-11-Methyl-
|
|
|
|
PSMD10 and RB1 |
proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 |
retinoblastoma 1 |
- Hedgehog 'off' state
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- T41 mutants of beta-catenin aren't phosphorylated
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- Stabilization of p53
- S33 mutants of beta-catenin aren't phosphorylated
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Mitotic G1-G1/S phases
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- DNA Replication Pre-Initiation
- S45 mutants of beta-catenin aren't phosphorylated
- APC/C:Cdc20 mediated degradation of mitotic proteins
- Regulation of APC/C activators between G1/S and early anaphase
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Autodegradation of the E3 ubiquitin ligase COP1
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- PCP/CE pathway
- Adaptive Immune System
- CDK-mediated phosphorylation and removal of Cdc6
- Hedgehog ligand biogenesis
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Separation of Sister Chromatids
- HIV Infection
- Ubiquitin-dependent degradation of Cyclin D
- APC truncation mutants have impaired AXIN binding
- Assembly of the pre-replicative complex
- Autodegradation of Cdh1 by Cdh1:APC/C
- p53-Dependent G1 DNA Damage Response
- S37 mutants of beta-catenin aren't phosphorylated
- XAV939 inhibits tankyrase, stabilizing AXIN
- p53-Independent DNA Damage Response
- p53-Independent G1/S DNA damage checkpoint
- G1/S DNA Damage Checkpoints
- Vpu mediated degradation of CD4
- Synthesis of DNA
- M/G1 Transition
- Ubiquitin-dependent degradation of Cyclin D1
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Signaling by Hedgehog
- Regulation of mitotic cell cycle
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Cell Cycle Checkpoints
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- p53-Dependent G1/S DNA damage checkpoint
- truncated APC mutants destabilize the destruction complex
- TCF7L2 mutants don't bind CTBP
- Signaling by Wnt
- Cyclin E associated events during G1/S transition
- APC/C:Cdc20 mediated degradation of Securin
- AUF1 (hnRNP D0) destabilizes mRNA
- CDK-mediated phosphorylation and removal of Cdc6
- RNF mutants show enhanced WNT signaling and proliferation
- G1/S Transition
- truncations of AMER1 destabilize the destruction complex
- Processing-defective Hh variants abrogate ligand secretion
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Cyclin A:Cdk2-associated events at S phase entry
- SCF(Skp2)-mediated degradation of p27/p21
- Mitotic Metaphase and Anaphase
- Regulation of ornithine decarboxylase (ODC)
- Antigen processing: Ubiquitination & Proteasome degradation
- Orc1 removal from chromatin
- Mitotic Anaphase
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- Metabolism of amino acids and derivatives
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- Regulation of DNA replication
- Cell Cycle, Mitotic
- beta-catenin independent WNT signaling
- Orc1 removal from chromatin
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- Cross-presentation of soluble exogenous antigens (endosomes)
- Antigen processing-Cross presentation
- CDT1 association with the CDC6:ORC:origin complex
- ER-Phagosome pathway
|
- E2F mediated regulation of DNA replication
- DNA Damage/Telomere Stress Induced Senescence
- Synthesis of DNA
- Mitotic Prophase
- Cellular Senescence
- G1 Phase
- Regulation of DNA replication
- Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
- Orc1 removal from chromatin
- S Phase
- Cyclin E associated events during G1/S transition
- Cell Cycle, Mitotic
- M Phase
- Orc1 removal from chromatin
- Cyclin D associated events in G1
- Formation of Senescence-Associated Heterochromatin Foci (SAHF)
- G1/S Transition
- Removal of licensing factors from origins
- Cyclin A:Cdk2-associated events at S phase entry
- Switching of origins to a post-replicative state
- Mitotic G1-G1/S phases
- Condensation of Prophase Chromosomes
- Inhibition of replication initiation of damaged DNA by RB1/E2F1
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|
|
|
|
RB1 and TAF1 |
retinoblastoma 1 |
TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa |
- E2F mediated regulation of DNA replication
- DNA Damage/Telomere Stress Induced Senescence
- Synthesis of DNA
- Mitotic Prophase
- Cellular Senescence
- G1 Phase
- Regulation of DNA replication
- Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
- Orc1 removal from chromatin
- S Phase
- Cyclin E associated events during G1/S transition
- Cell Cycle, Mitotic
- M Phase
- Orc1 removal from chromatin
- Cyclin D associated events in G1
- Formation of Senescence-Associated Heterochromatin Foci (SAHF)
- G1/S Transition
- Removal of licensing factors from origins
- Cyclin A:Cdk2-associated events at S phase entry
- Switching of origins to a post-replicative state
- Mitotic G1-G1/S phases
- Condensation of Prophase Chromosomes
- Inhibition of replication initiation of damaged DNA by RB1/E2F1
|
- RNA Polymerase II Promoter Escape
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
- RNA Polymerase II Transcription
- HIV Infection
- RNA Polymerase II Pre-transcription Events
- Late Phase of HIV Life Cycle
- HIV Life Cycle
- HIV Transcription Initiation
- RNA Polymerase II Transcription Initiation And Promoter Clearance
- RNA Polymerase II HIV Promoter Escape
- RNA Polymerase II Transcription Initiation
- Transcription of the HIV genome
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