Diabetes - Wiki-Pi

Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide
HNF4A and PCBD1	hepatocyte nuclear factor 4, alpha	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha	Generic Transcription Pathway Nuclear Receptor transcription pathway	Phenylalanine and tyrosine catabolism Metabolism of amino acids and derivatives
HNF4A and TRIM24	hepatocyte nuclear factor 4, alpha	tripartite motif containing 24	Generic Transcription Pathway Nuclear Receptor transcription pathway	Signaling by FGFR in disease Signaling by FGFR1 mutants Signaling by FGFR mutants Signaling by FGFR1 fusion mutants
HNF4A and COPS5	hepatocyte nuclear factor 4, alpha	COP9 signalosome subunit 5	Generic Transcription Pathway Nuclear Receptor transcription pathway
HNF4A and ZNHIT3	hepatocyte nuclear factor 4, alpha	zinc finger, HIT-type containing 3	Generic Transcription Pathway Nuclear Receptor transcription pathway
HNF4A and NR0B2	hepatocyte nuclear factor 4, alpha	nuclear receptor subfamily 0, group B, member 2	Generic Transcription Pathway Nuclear Receptor transcription pathway	Generic Transcription Pathway Nuclear Receptor transcription pathway
HNF4A and NR2F1	hepatocyte nuclear factor 4, alpha	nuclear receptor subfamily 2, group F, member 1	Generic Transcription Pathway Nuclear Receptor transcription pathway	Generic Transcription Pathway Nuclear Receptor transcription pathway
HNF4A and NR1I3	hepatocyte nuclear factor 4, alpha	nuclear receptor subfamily 1, group I, member 3	Generic Transcription Pathway Nuclear Receptor transcription pathway
HNF4A and SIRT1	hepatocyte nuclear factor 4, alpha	sirtuin 1	Generic Transcription Pathway Nuclear Receptor transcription pathway	Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression SIRT1 negatively regulates rRNA Expression Cellular response to heat stress Regulation of HSF1-mediated heat shock response
HNF4A and TP53	hepatocyte nuclear factor 4, alpha	tumor protein p53	Generic Transcription Pathway Nuclear Receptor transcription pathway	Cellular Senescence Activation of BH3-only proteins p53-Dependent G1/S DNA damage checkpoint Oncogene Induced Senescence p53-Dependent G1 DNA Damage Response Formation of Senescence-Associated Heterochromatin Foci (SAHF) Pre-NOTCH Transcription and Translation Stabilization of p53 Transcriptional activation of p53 responsive genes Programmed Cell Death Pre-NOTCH Expression and Processing G1/S DNA Damage Checkpoints Intrinsic Pathway for Apoptosis Transcriptional activation of cell cycle inhibitor p21 DNA Damage/Telomere Stress Induced Senescence Signaling by NOTCH Factors involved in megakaryocyte development and platelet production Activation of NOXA and translocation to mitochondria Oxidative Stress Induced Senescence Autodegradation of the E3 ubiquitin ligase COP1 Activation of PUMA and translocation to mitochondria Cell Cycle Checkpoints
HNF4A and SMAD2	hepatocyte nuclear factor 4, alpha	SMAD family member 2	Generic Transcription Pathway Nuclear Receptor transcription pathway	Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Signaling by NODAL TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Signaling by Activin TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
HNF4A and SMAD3	hepatocyte nuclear factor 4, alpha	SMAD family member 3	Generic Transcription Pathway Nuclear Receptor transcription pathway	Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Signaling by NODAL TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Signaling by Activin TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
HNF4A and SMAD4	hepatocyte nuclear factor 4, alpha	SMAD family member 4	Generic Transcription Pathway Nuclear Receptor transcription pathway	Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by BMP Transcriptional regulation of pluripotent stem cells Generic Transcription Pathway Signaling by NODAL TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Signaling by Activin TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
HNF4A and RNF4	hepatocyte nuclear factor 4, alpha	ring finger protein 4	Generic Transcription Pathway Nuclear Receptor transcription pathway	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
HNF4A and TGS1	hepatocyte nuclear factor 4, alpha	trimethylguanosine synthase 1	Generic Transcription Pathway Nuclear Receptor transcription pathway	PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Metabolism of non-coding RNA REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis Regulation of cholesterol biosynthesis by SREBP (SREBF) Generic Transcription Pathway snRNP Assembly Transcriptional regulation of white adipocyte differentiation YAP1- and WWTR1 (TAZ)-stimulated gene expression Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression Orphan transporters
HNRNPD and IGF2BP2	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	insulin-like growth factor 2 mRNA binding protein 2	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
HSPA5 and MTNR1B	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	melatonin receptor 1B	Platelet degranulation Antigen Presentation: Folding, assembly and peptide loading of class I MHC ATF6-alpha activates chaperone genes IRE1alpha activates chaperones Response to elevated platelet cytosolic Ca2+ Class I MHC mediated antigen processing & presentation Platelet activation, signaling and aggregation ATF6-alpha activates chaperones PERK regulates gene expression Unfolded Protein Response (UPR) Adaptive Immune System	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Antihemophilic Factor	Ramelteon Melatonin Agomelatine
HSPB1 and INS	heat shock 27kDa protein 1	insulin	Regulation of mRNA stability by proteins that bind AU-rich elements Signaling by VEGF AUF1 (hnRNP D0) destabilizes mRNA VEGFA-VEGFR2 Pathway	Synthesis, secretion, and deacylation of Ghrelin Insulin receptor signalling cascade Integration of energy metabolism Regulation of insulin secretion IRS-related events SHC-related events Insulin receptor recycling Peptide hormone metabolism IRS activation Regulation of beta-cell development Signal attenuation Regulation of gene expression in beta cells Insulin processing SHC activation Signaling by Insulin receptor
ICAM1 and IL2RA	intercellular adhesion molecule 1	interleukin 2 receptor, alpha	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling	Natalizumab Hyaluronan	Denileukin diftitox Aldesleukin Basiliximab Daclizumab
ICAM3 and PRKCQ	intercellular adhesion molecule 3	protein kinase C, theta	Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	G alpha (q) signalling events Signaling by GPCR Downstream TCR signaling Axon guidance Effects of PIP2 hydrolysis FCERI mediated NF-kB activation Inactivation, recovery and regulation of the phototransduction cascade Gastrin-CREB signalling pathway via PKC and MAPK The phototransduction cascade Programmed Cell Death G alpha (z) signalling events Netrin-1 signaling Innate Immune System Apoptotic cleavage of cellular proteins Apoptotic execution phase Diseases associated with visual transduction G alpha (q) signalling events GPCR downstream signaling TCR signaling Visual phototransduction Fc epsilon receptor (FCERI) signaling Platelet activation, signaling and aggregation Adaptive Immune System		Staurosporine Phosphonothreonine Phosphonoserine
IFNA1 and IL2	interferon, alpha 1	interleukin 2	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Regulation of IFNA signaling Interferon Signaling TRAF6 mediated IRF7 activation Cytokine Signaling in Immune system Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production Innate Immune System	Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling		SP4160 5-[2,3-Dichloro-4-(5-{1-[2-(2-Guanidino-4-Methyl-Pentanoylamino)-Acetyl]-Piperidin-4-Yl}-1-Methyl-1h-Pyrazol-3-Yl)-Phenoxymethyl]-Furan-2-Carboxylic Acid 3-Mercapto-1-(1,3,4,9-Tetrahydro-B-Carbolin-2-Yl)-Propan-1-One (R)-N-[2-[1-(Aminoiminomethyl)-3-Piperidinyl]-1-Oxoethyl]-4-(Phenylethynyl)-L-Phenylalanine Methylester (1h-Indol-3-Yl)-(2-Mercapto-Ethoxyimino)-Acetic Acid SP2456 2-[2-(2-Cyclohexyl-2-Guanidino-Acetylamino)-Acetylamino]-N-(3-Mercapto-Propyl)-Propionamide

Search Results for: Diabetes