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RPS27A and SMAD4	ribosomal protein S27a	SMAD family member 4	Loss of Function of TGFBR2 in Cancer NF-kB is activated and signals survival Hedgehog 'off' state Signaling by FGFR in disease Influenza Life Cycle Glucose metabolism Toll Like Receptor TLR1:TLR2 Cascade Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Formation of the ternary complex, and subsequently, the 43S complex Signaling by NOTCH1 Signaling by NOTCH2 Toll Like Receptor 5 (TLR5) Cascade S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Stabilization of p53 Removal of licensing factors from origins Switching of origins to a post-replicative state Downregulation of ERBB2:ERBB3 signaling TGFBR2 MSI Frameshift Mutants in Cancer Signaling by NOTCH Endosomal Sorting Complex Required For Transport (ESCRT) Spry regulation of FGF signaling Influenza Infection Signaling by NOTCH SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Regulation of innate immune responses to cytosolic DNA Autodegradation of the E3 ubiquitin ligase COP1 Toll Like Receptor 3 (TLR3) Cascade Metabolism of carbohydrates CDK-mediated phosphorylation and removal of Cdc6 Cellular response to hypoxia Hedgehog ligand biogenesis p75NTR recruits signalling complexes Fanconi Anemia pathway Separation of Sister Chromatids APC truncation mutants have impaired AXIN binding HIV Infection Peptide chain elongation Assembly of the pre-replicative complex Activated TLR4 signalling Synthesis And Processing Of GAG, GAGPOL Polyproteins S37 mutants of beta-catenin aren't phosphorylated p53-Dependent G1 DNA Damage Response Signaling by NOTCH1 PEST Domain Mutants in Cancer regulation of FZD by ubiquitination Signaling by NOTCH1 p53-Independent DNA Damage Response MyD88:Mal cascade initiated on plasma membrane Stimuli-sensing channels p53-Independent G1/S DNA damage checkpoint Membrane binding and targetting of GAG proteins G1/S DNA Damage Checkpoints Downregulation of ERBB4 signaling Vpu mediated degradation of CD4 Cell death signalling via NRAGE, NRIF and NADE ISG15 antiviral mechanism Interferon Signaling Eukaryotic Translation Termination M/G1 Transition p75 NTR receptor-mediated signalling Signaling by FGFR Toll Like Receptor 10 (TLR10) Cascade Signaling by NOTCH1 in Cancer TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Degradation of GLI1 by the proteasome Cell Cycle Checkpoints degradation of DVL Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Translation initiation complex formation Vif-mediated degradation of APOBEC3G Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Downregulation of TGF-beta receptor signaling truncated APC mutants destabilize the destruction complex Cyclin E associated events during G1/S transition TGF-beta receptor signaling activates SMADs Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Generic Transcription Pathway Regulation of the Fanconi anemia pathway G1/S Transition FBXW7 Mutants and NOTCH1 in Cancer Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex truncations of AMER1 destabilize the destruction complex Negative regulation of FGFR signaling EGFR downregulation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Translation IRAK2 mediated activation of TAK1 complex Processing-defective Hh variants abrogate ligand secretion Regulation of activated PAK-2p34 by proteasome mediated degradation phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Host Interactions of HIV factors Signaling by ERBB4 Antiviral mechanism by IFN-stimulated genes Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Fc epsilon receptor (FCERI) signaling Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Interleukin-3, 5 and GM-CSF signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex APC truncation mutants are not K63 polyubiquitinated M Phase Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon HIV Life Cycle Budding and maturation of HIV virion Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation IKK complex recruitment mediated by RIP1 MAP kinase activation in TLR cascade Regulation of DNA replication Cytokine Signaling in Immune system MyD88-independent cascade Signaling by Overexpressed Wild-Type EGFR in Cancer Viral mRNA Translation Cell Cycle, Mitotic Signaling by TGF-beta Receptor Complex in Cancer Oxidative Stress Induced Senescence Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Formation of a pool of free 40S subunits TRAF6 mediated induction of TAK1 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Negative regulators of RIG-I/MDA5 signaling misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease Cellular Senescence T41 mutants of beta-catenin aren't phosphorylated SMAD2/3 MH2 Domain Mutants in Cancer Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by EGFRvIII in Cancer Downstream signaling events of B Cell Receptor (BCR) Assembly Of The HIV Virion Degradation of beta-catenin by the destruction complex Influenza Viral RNA Transcription and Replication NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome Glycogen storage diseases Cap-dependent Translation Initiation Mitotic G1-G1/S phases activated TAK1 mediates p38 MAPK activation Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling DNA Replication Pre-Initiation Senescence-Associated Secretory Phenotype (SASP) S45 mutants of beta-catenin aren't phosphorylated APC/C:Cdc20 mediated degradation of mitotic proteins TGFBR1 KD Mutants in Cancer Regulation of APC/C activators between G1/S and early anaphase L13a-mediated translational silencing of Ceruloplasmin expression Late Phase of HIV Life Cycle APC/C:Cdc20 mediated degradation of Cyclin B NOTCH2 Activation and Transmission of Signal to the Nucleus Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) TCR signaling AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Interleukin-1 signaling Eukaryotic Translation Elongation PCP/CE pathway Mitotic G2-G2/M phases Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Adaptive Immune System APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Ubiquitin-dependent degradation of Cyclin D G2/M Transition Oncogene Induced Senescence TGFBR1 LBD Mutants in Cancer Autodegradation of Cdh1 by Cdh1:APC/C Ion channel transport Eukaryotic Translation Initiation p75NTR signals via NF-kB Regulation of signaling by CBL Disease XAV939 inhibits tankyrase, stabilizing AXIN TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Signal Transduction Innate Immune System Nonsense-Mediated Decay (NMD) Synthesis of DNA Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Signaling by Ligand-Responsive EGFR Variants in Cancer Loss of Function of TGFBR1 in Cancer Ubiquitin-dependent degradation of Cyclin D1 Activated NOTCH1 Transmits Signal to the Nucleus Toll-Like Receptors Cascades NOTCH1 Intracellular Domain Regulates Transcription Cyclin D associated events in G1 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Regulation of mitotic cell cycle Signaling by Hedgehog Association of licensing factors with the pre-replicative complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Ubiquitin Mediated Degradation of Phosphorylated Cdc25A TCF7L2 mutants don't bind CTBP p53-Dependent G1/S DNA damage checkpoint Signaling by Wnt Downregulation of SMAD2/3:SMAD4 transcriptional activity APC/C:Cdc20 mediated degradation of Securin AUF1 (hnRNP D0) destabilizes mRNA SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription CDK-mediated phosphorylation and removal of Cdc6 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer IRAK1 recruits IKK complex Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants RNF mutants show enhanced WNT signaling and proliferation Myoclonic epilepsy of Lafora Signaling by NOTCH1 in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer IRAK2 mediated activation of TAK1 complex SRP-dependent cotranslational protein targeting to membrane Loss of Function of SMAD4 in Cancer AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins Glycogen synthesis NRIF signals cell death from the nucleus Toll Like Receptor 4 (TLR4) Cascade Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by EGFR in Cancer SCF(Skp2)-mediated degradation of p27/p21 Cyclin A:Cdk2-associated events at S phase entry Constitutive Signaling by NOTCH1 PEST Domain Mutants Mitotic Metaphase and Anaphase Downstream TCR signaling Antigen processing: Ubiquitination & Proteasome degradation Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Toll Like Receptor 7/8 (TLR7/8) Cascade Orc1 removal from chromatin Mitotic Anaphase deactivation of the beta-catenin transactivating complex Toll Like Receptor TLR6:TLR2 Cascade MyD88 cascade initiated on plasma membrane Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 FBXW7 Mutants and NOTCH1 in Cancer Signalling by NGF Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Cytosolic sensors of pathogen-associated DNA beta-catenin independent WNT signaling Ribosomal scanning and start codon recognition RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Orc1 removal from chromatin GTP hydrolysis and joining of the 60S ribosomal subunit Signaling by TGF-beta Receptor Complex CDT1 association with the CDC6:ORC:origin complex Antigen processing-Cross presentation ER-Phagosome pathway SMAD4 MH2 Domain Mutants in Cancer	Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by BMP Transcriptional regulation of pluripotent stem cells Generic Transcription Pathway Signaling by NODAL TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Signaling by Activin TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
RPS27A and SMAD2	ribosomal protein S27a	SMAD family member 2	Loss of Function of TGFBR2 in Cancer NF-kB is activated and signals survival Hedgehog 'off' state Signaling by FGFR in disease Influenza Life Cycle Glucose metabolism Toll Like Receptor TLR1:TLR2 Cascade Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Formation of the ternary complex, and subsequently, the 43S complex Signaling by NOTCH1 Signaling by NOTCH2 Toll Like Receptor 5 (TLR5) Cascade S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Stabilization of p53 Removal of licensing factors from origins Switching of origins to a post-replicative state Downregulation of ERBB2:ERBB3 signaling TGFBR2 MSI Frameshift Mutants in Cancer Signaling by NOTCH Endosomal Sorting Complex Required For Transport (ESCRT) Spry regulation of FGF signaling Influenza Infection Signaling by NOTCH SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Regulation of innate immune responses to cytosolic DNA Autodegradation of the E3 ubiquitin ligase COP1 Toll Like Receptor 3 (TLR3) Cascade Metabolism of carbohydrates CDK-mediated phosphorylation and removal of Cdc6 Cellular response to hypoxia Hedgehog ligand biogenesis p75NTR recruits signalling complexes Fanconi Anemia pathway Separation of Sister Chromatids APC truncation mutants have impaired AXIN binding HIV Infection Peptide chain elongation Assembly of the pre-replicative complex Activated TLR4 signalling Synthesis And Processing Of GAG, GAGPOL Polyproteins S37 mutants of beta-catenin aren't phosphorylated p53-Dependent G1 DNA Damage Response Signaling by NOTCH1 PEST Domain Mutants in Cancer regulation of FZD by ubiquitination Signaling by NOTCH1 p53-Independent DNA Damage Response MyD88:Mal cascade initiated on plasma membrane Stimuli-sensing channels p53-Independent G1/S DNA damage checkpoint Membrane binding and targetting of GAG proteins G1/S DNA Damage Checkpoints Downregulation of ERBB4 signaling Vpu mediated degradation of CD4 Cell death signalling via NRAGE, NRIF and NADE ISG15 antiviral mechanism Interferon Signaling Eukaryotic Translation Termination M/G1 Transition p75 NTR receptor-mediated signalling Signaling by FGFR Toll Like Receptor 10 (TLR10) Cascade Signaling by NOTCH1 in Cancer TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Degradation of GLI1 by the proteasome Cell Cycle Checkpoints degradation of DVL Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Translation initiation complex formation Vif-mediated degradation of APOBEC3G Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Downregulation of TGF-beta receptor signaling truncated APC mutants destabilize the destruction complex Cyclin E associated events during G1/S transition TGF-beta receptor signaling activates SMADs Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Generic Transcription Pathway Regulation of the Fanconi anemia pathway G1/S Transition FBXW7 Mutants and NOTCH1 in Cancer Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex truncations of AMER1 destabilize the destruction complex Negative regulation of FGFR signaling EGFR downregulation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Translation IRAK2 mediated activation of TAK1 complex Processing-defective Hh variants abrogate ligand secretion Regulation of activated PAK-2p34 by proteasome mediated degradation phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Host Interactions of HIV factors Signaling by ERBB4 Antiviral mechanism by IFN-stimulated genes Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Fc epsilon receptor (FCERI) signaling Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Interleukin-3, 5 and GM-CSF signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex APC truncation mutants are not K63 polyubiquitinated M Phase Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon HIV Life Cycle Budding and maturation of HIV virion Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation IKK complex recruitment mediated by RIP1 MAP kinase activation in TLR cascade Regulation of DNA replication Cytokine Signaling in Immune system MyD88-independent cascade Signaling by Overexpressed Wild-Type EGFR in Cancer Viral mRNA Translation Cell Cycle, Mitotic Signaling by TGF-beta Receptor Complex in Cancer Oxidative Stress Induced Senescence Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Formation of a pool of free 40S subunits TRAF6 mediated induction of TAK1 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Negative regulators of RIG-I/MDA5 signaling misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease Cellular Senescence T41 mutants of beta-catenin aren't phosphorylated SMAD2/3 MH2 Domain Mutants in Cancer Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by EGFRvIII in Cancer Downstream signaling events of B Cell Receptor (BCR) Assembly Of The HIV Virion Degradation of beta-catenin by the destruction complex Influenza Viral RNA Transcription and Replication NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome Glycogen storage diseases Cap-dependent Translation Initiation Mitotic G1-G1/S phases activated TAK1 mediates p38 MAPK activation Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling DNA Replication Pre-Initiation Senescence-Associated Secretory Phenotype (SASP) S45 mutants of beta-catenin aren't phosphorylated APC/C:Cdc20 mediated degradation of mitotic proteins TGFBR1 KD Mutants in Cancer Regulation of APC/C activators between G1/S and early anaphase L13a-mediated translational silencing of Ceruloplasmin expression Late Phase of HIV Life Cycle APC/C:Cdc20 mediated degradation of Cyclin B NOTCH2 Activation and Transmission of Signal to the Nucleus Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) TCR signaling AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Interleukin-1 signaling Eukaryotic Translation Elongation PCP/CE pathway Mitotic G2-G2/M phases Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Adaptive Immune System APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Ubiquitin-dependent degradation of Cyclin D G2/M Transition Oncogene Induced Senescence TGFBR1 LBD Mutants in Cancer Autodegradation of Cdh1 by Cdh1:APC/C Ion channel transport Eukaryotic Translation Initiation p75NTR signals via NF-kB Regulation of signaling by CBL Disease XAV939 inhibits tankyrase, stabilizing AXIN TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Signal Transduction Innate Immune System Nonsense-Mediated Decay (NMD) Synthesis of DNA Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Signaling by Ligand-Responsive EGFR Variants in Cancer Loss of Function of TGFBR1 in Cancer Ubiquitin-dependent degradation of Cyclin D1 Activated NOTCH1 Transmits Signal to the Nucleus Toll-Like Receptors Cascades NOTCH1 Intracellular Domain Regulates Transcription Cyclin D associated events in G1 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Regulation of mitotic cell cycle Signaling by Hedgehog Association of licensing factors with the pre-replicative complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Ubiquitin Mediated Degradation of Phosphorylated Cdc25A TCF7L2 mutants don't bind CTBP p53-Dependent G1/S DNA damage checkpoint Signaling by Wnt Downregulation of SMAD2/3:SMAD4 transcriptional activity APC/C:Cdc20 mediated degradation of Securin AUF1 (hnRNP D0) destabilizes mRNA SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription CDK-mediated phosphorylation and removal of Cdc6 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer IRAK1 recruits IKK complex Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants RNF mutants show enhanced WNT signaling and proliferation Myoclonic epilepsy of Lafora Signaling by NOTCH1 in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer IRAK2 mediated activation of TAK1 complex SRP-dependent cotranslational protein targeting to membrane Loss of Function of SMAD4 in Cancer AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins Glycogen synthesis NRIF signals cell death from the nucleus Toll Like Receptor 4 (TLR4) Cascade Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by EGFR in Cancer SCF(Skp2)-mediated degradation of p27/p21 Cyclin A:Cdk2-associated events at S phase entry Constitutive Signaling by NOTCH1 PEST Domain Mutants Mitotic Metaphase and Anaphase Downstream TCR signaling Antigen processing: Ubiquitination & Proteasome degradation Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Toll Like Receptor 7/8 (TLR7/8) Cascade Orc1 removal from chromatin Mitotic Anaphase deactivation of the beta-catenin transactivating complex Toll Like Receptor TLR6:TLR2 Cascade MyD88 cascade initiated on plasma membrane Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 FBXW7 Mutants and NOTCH1 in Cancer Signalling by NGF Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Cytosolic sensors of pathogen-associated DNA beta-catenin independent WNT signaling Ribosomal scanning and start codon recognition RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Orc1 removal from chromatin GTP hydrolysis and joining of the 60S ribosomal subunit Signaling by TGF-beta Receptor Complex CDT1 association with the CDC6:ORC:origin complex Antigen processing-Cross presentation ER-Phagosome pathway SMAD4 MH2 Domain Mutants in Cancer	Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Signaling by NODAL TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Signaling by Activin TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
RPS27A and TGFBR1	ribosomal protein S27a	transforming growth factor, beta receptor 1	Loss of Function of TGFBR2 in Cancer NF-kB is activated and signals survival Hedgehog 'off' state Signaling by FGFR in disease Influenza Life Cycle Glucose metabolism Toll Like Receptor TLR1:TLR2 Cascade Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Formation of the ternary complex, and subsequently, the 43S complex Signaling by NOTCH1 Signaling by NOTCH2 Toll Like Receptor 5 (TLR5) Cascade S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Stabilization of p53 Removal of licensing factors from origins Switching of origins to a post-replicative state Downregulation of ERBB2:ERBB3 signaling TGFBR2 MSI Frameshift Mutants in Cancer Signaling by NOTCH Endosomal Sorting Complex Required For Transport (ESCRT) Spry regulation of FGF signaling Influenza Infection Signaling by NOTCH SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Regulation of innate immune responses to cytosolic DNA Autodegradation of the E3 ubiquitin ligase COP1 Toll Like Receptor 3 (TLR3) Cascade Metabolism of carbohydrates CDK-mediated phosphorylation and removal of Cdc6 Cellular response to hypoxia Hedgehog ligand biogenesis p75NTR recruits signalling complexes Fanconi Anemia pathway Separation of Sister Chromatids APC truncation mutants have impaired AXIN binding HIV Infection Peptide chain elongation Assembly of the pre-replicative complex Activated TLR4 signalling Synthesis And Processing Of GAG, GAGPOL Polyproteins S37 mutants of beta-catenin aren't phosphorylated p53-Dependent G1 DNA Damage Response Signaling by NOTCH1 PEST Domain Mutants in Cancer regulation of FZD by ubiquitination Signaling by NOTCH1 p53-Independent DNA Damage Response MyD88:Mal cascade initiated on plasma membrane Stimuli-sensing channels p53-Independent G1/S DNA damage checkpoint Membrane binding and targetting of GAG proteins G1/S DNA Damage Checkpoints Downregulation of ERBB4 signaling Vpu mediated degradation of CD4 Cell death signalling via NRAGE, NRIF and NADE ISG15 antiviral mechanism Interferon Signaling Eukaryotic Translation Termination M/G1 Transition p75 NTR receptor-mediated signalling Signaling by FGFR Toll Like Receptor 10 (TLR10) Cascade Signaling by NOTCH1 in Cancer TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Degradation of GLI1 by the proteasome Cell Cycle Checkpoints degradation of DVL Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Translation initiation complex formation Vif-mediated degradation of APOBEC3G Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Downregulation of TGF-beta receptor signaling truncated APC mutants destabilize the destruction complex Cyclin E associated events during G1/S transition TGF-beta receptor signaling activates SMADs Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Generic Transcription Pathway Regulation of the Fanconi anemia pathway G1/S Transition FBXW7 Mutants and NOTCH1 in Cancer Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex truncations of AMER1 destabilize the destruction complex Negative regulation of FGFR signaling EGFR downregulation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Translation IRAK2 mediated activation of TAK1 complex Processing-defective Hh variants abrogate ligand secretion Regulation of activated PAK-2p34 by proteasome mediated degradation phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Host Interactions of HIV factors Signaling by ERBB4 Antiviral mechanism by IFN-stimulated genes Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Fc epsilon receptor (FCERI) signaling Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Interleukin-3, 5 and GM-CSF signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex APC truncation mutants are not K63 polyubiquitinated M Phase Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon HIV Life Cycle Budding and maturation of HIV virion Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation IKK complex recruitment mediated by RIP1 MAP kinase activation in TLR cascade Regulation of DNA replication Cytokine Signaling in Immune system MyD88-independent cascade Signaling by Overexpressed Wild-Type EGFR in Cancer Viral mRNA Translation Cell Cycle, Mitotic Signaling by TGF-beta Receptor Complex in Cancer Oxidative Stress Induced Senescence Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Formation of a pool of free 40S subunits TRAF6 mediated induction of TAK1 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Negative regulators of RIG-I/MDA5 signaling misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease Cellular Senescence T41 mutants of beta-catenin aren't phosphorylated SMAD2/3 MH2 Domain Mutants in Cancer Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by EGFRvIII in Cancer Downstream signaling events of B Cell Receptor (BCR) Assembly Of The HIV Virion Degradation of beta-catenin by the destruction complex Influenza Viral RNA Transcription and Replication NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome Glycogen storage diseases Cap-dependent Translation Initiation Mitotic G1-G1/S phases activated TAK1 mediates p38 MAPK activation Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling DNA Replication Pre-Initiation Senescence-Associated Secretory Phenotype (SASP) S45 mutants of beta-catenin aren't phosphorylated APC/C:Cdc20 mediated degradation of mitotic proteins TGFBR1 KD Mutants in Cancer Regulation of APC/C activators between G1/S and early anaphase L13a-mediated translational silencing of Ceruloplasmin expression Late Phase of HIV Life Cycle APC/C:Cdc20 mediated degradation of Cyclin B NOTCH2 Activation and Transmission of Signal to the Nucleus Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) TCR signaling AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Interleukin-1 signaling Eukaryotic Translation Elongation PCP/CE pathway Mitotic G2-G2/M phases Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Adaptive Immune System APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Ubiquitin-dependent degradation of Cyclin D G2/M Transition Oncogene Induced Senescence TGFBR1 LBD Mutants in Cancer Autodegradation of Cdh1 by Cdh1:APC/C Ion channel transport Eukaryotic Translation Initiation p75NTR signals via NF-kB Regulation of signaling by CBL Disease XAV939 inhibits tankyrase, stabilizing AXIN TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Signal Transduction Innate Immune System Nonsense-Mediated Decay (NMD) Synthesis of DNA Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Signaling by Ligand-Responsive EGFR Variants in Cancer Loss of Function of TGFBR1 in Cancer Ubiquitin-dependent degradation of Cyclin D1 Activated NOTCH1 Transmits Signal to the Nucleus Toll-Like Receptors Cascades NOTCH1 Intracellular Domain Regulates Transcription Cyclin D associated events in G1 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Regulation of mitotic cell cycle Signaling by Hedgehog Association of licensing factors with the pre-replicative complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Ubiquitin Mediated Degradation of Phosphorylated Cdc25A TCF7L2 mutants don't bind CTBP p53-Dependent G1/S DNA damage checkpoint Signaling by Wnt Downregulation of SMAD2/3:SMAD4 transcriptional activity APC/C:Cdc20 mediated degradation of Securin AUF1 (hnRNP D0) destabilizes mRNA SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription CDK-mediated phosphorylation and removal of Cdc6 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer IRAK1 recruits IKK complex Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants RNF mutants show enhanced WNT signaling and proliferation Myoclonic epilepsy of Lafora Signaling by NOTCH1 in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer IRAK2 mediated activation of TAK1 complex SRP-dependent cotranslational protein targeting to membrane Loss of Function of SMAD4 in Cancer AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins Glycogen synthesis NRIF signals cell death from the nucleus Toll Like Receptor 4 (TLR4) Cascade Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by EGFR in Cancer SCF(Skp2)-mediated degradation of p27/p21 Cyclin A:Cdk2-associated events at S phase entry Constitutive Signaling by NOTCH1 PEST Domain Mutants Mitotic Metaphase and Anaphase Downstream TCR signaling Antigen processing: Ubiquitination & Proteasome degradation Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Toll Like Receptor 7/8 (TLR7/8) Cascade Orc1 removal from chromatin Mitotic Anaphase deactivation of the beta-catenin transactivating complex Toll Like Receptor TLR6:TLR2 Cascade MyD88 cascade initiated on plasma membrane Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 FBXW7 Mutants and NOTCH1 in Cancer Signalling by NGF Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Cytosolic sensors of pathogen-associated DNA beta-catenin independent WNT signaling Ribosomal scanning and start codon recognition RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Orc1 removal from chromatin GTP hydrolysis and joining of the 60S ribosomal subunit Signaling by TGF-beta Receptor Complex CDT1 association with the CDC6:ORC:origin complex Antigen processing-Cross presentation ER-Phagosome pathway SMAD4 MH2 Domain Mutants in Cancer	Loss of Function of TGFBR2 in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
UBA52 and SMAD4	ubiquitin A-52 residue ribosomal protein fusion product 1	SMAD family member 4	Loss of Function of TGFBR2 in Cancer NF-kB is activated and signals survival Hedgehog 'off' state Signaling by FGFR in disease Influenza Life Cycle Toll Like Receptor TLR1:TLR2 Cascade Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Glucose metabolism Signaling by NOTCH1 Signaling by NOTCH2 Toll Like Receptor 5 (TLR5) Cascade S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Stabilization of p53 Removal of licensing factors from origins Switching of origins to a post-replicative state Downregulation of ERBB2:ERBB3 signaling TGFBR2 MSI Frameshift Mutants in Cancer Signaling by NOTCH Endosomal Sorting Complex Required For Transport (ESCRT) Spry regulation of FGF signaling Influenza Infection Signaling by NOTCH SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Regulation of innate immune responses to cytosolic DNA Autodegradation of the E3 ubiquitin ligase COP1 Toll Like Receptor 3 (TLR3) Cascade Metabolism of carbohydrates CDK-mediated phosphorylation and removal of Cdc6 Cellular response to hypoxia Hedgehog ligand biogenesis p75NTR recruits signalling complexes Fanconi Anemia pathway Separation of Sister Chromatids APC truncation mutants have impaired AXIN binding HIV Infection Peptide chain elongation Assembly of the pre-replicative complex Activated TLR4 signalling Synthesis And Processing Of GAG, GAGPOL Polyproteins S37 mutants of beta-catenin aren't phosphorylated p53-Dependent G1 DNA Damage Response Signaling by NOTCH1 PEST Domain Mutants in Cancer regulation of FZD by ubiquitination Signaling by NOTCH1 p53-Independent DNA Damage Response MyD88:Mal cascade initiated on plasma membrane Stimuli-sensing channels p53-Independent G1/S DNA damage checkpoint Membrane binding and targetting of GAG proteins G1/S DNA Damage Checkpoints Downregulation of ERBB4 signaling Vpu mediated degradation of CD4 Cell death signalling via NRAGE, NRIF and NADE ISG15 antiviral mechanism Interferon Signaling Eukaryotic Translation Termination M/G1 Transition p75 NTR receptor-mediated signalling Signaling by FGFR Toll Like Receptor 10 (TLR10) Cascade Signaling by NOTCH1 in Cancer TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Degradation of GLI1 by the proteasome Cell Cycle Checkpoints degradation of DVL Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Downregulation of TGF-beta receptor signaling truncated APC mutants destabilize the destruction complex Cyclin E associated events during G1/S transition TGF-beta receptor signaling activates SMADs Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Generic Transcription Pathway Regulation of the Fanconi anemia pathway G1/S Transition FBXW7 Mutants and NOTCH1 in Cancer Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex truncations of AMER1 destabilize the destruction complex Negative regulation of FGFR signaling EGFR downregulation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Translation IRAK2 mediated activation of TAK1 complex Processing-defective Hh variants abrogate ligand secretion Regulation of activated PAK-2p34 by proteasome mediated degradation phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Host Interactions of HIV factors Signaling by ERBB4 Antiviral mechanism by IFN-stimulated genes Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex APC truncation mutants are not K63 polyubiquitinated M Phase Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon HIV Life Cycle Budding and maturation of HIV virion Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation IKK complex recruitment mediated by RIP1 MAP kinase activation in TLR cascade Regulation of DNA replication Cytokine Signaling in Immune system MyD88-independent cascade Signaling by Overexpressed Wild-Type EGFR in Cancer Viral mRNA Translation Cell Cycle, Mitotic Signaling by TGF-beta Receptor Complex in Cancer Oxidative Stress Induced Senescence Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Formation of a pool of free 40S subunits TRAF6 mediated induction of TAK1 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Negative regulators of RIG-I/MDA5 signaling misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease Cellular Senescence T41 mutants of beta-catenin aren't phosphorylated SMAD2/3 MH2 Domain Mutants in Cancer Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by EGFRvIII in Cancer Downstream signaling events of B Cell Receptor (BCR) Assembly Of The HIV Virion Degradation of beta-catenin by the destruction complex Influenza Viral RNA Transcription and Replication NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome Glycogen storage diseases Cap-dependent Translation Initiation Mitotic G1-G1/S phases activated TAK1 mediates p38 MAPK activation Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling DNA Replication Pre-Initiation Senescence-Associated Secretory Phenotype (SASP) S45 mutants of beta-catenin aren't phosphorylated APC/C:Cdc20 mediated degradation of mitotic proteins TGFBR1 KD Mutants in Cancer Regulation of APC/C activators between G1/S and early anaphase L13a-mediated translational silencing of Ceruloplasmin expression Late Phase of HIV Life Cycle APC/C:Cdc20 mediated degradation of Cyclin B NOTCH2 Activation and Transmission of Signal to the Nucleus Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) TCR signaling AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Interleukin-1 signaling Eukaryotic Translation Elongation PCP/CE pathway Mitotic G2-G2/M phases Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Adaptive Immune System APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Ubiquitin-dependent degradation of Cyclin D G2/M Transition Oncogene Induced Senescence TGFBR1 LBD Mutants in Cancer Autodegradation of Cdh1 by Cdh1:APC/C Ion channel transport Eukaryotic Translation Initiation p75NTR signals via NF-kB Regulation of signaling by CBL Disease XAV939 inhibits tankyrase, stabilizing AXIN TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Signal Transduction Innate Immune System Nonsense-Mediated Decay (NMD) Synthesis of DNA Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Signaling by Ligand-Responsive EGFR Variants in Cancer Loss of Function of TGFBR1 in Cancer Ubiquitin-dependent degradation of Cyclin D1 Activated NOTCH1 Transmits Signal to the Nucleus Toll-Like Receptors Cascades NOTCH1 Intracellular Domain Regulates Transcription Cyclin D associated events in G1 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Regulation of mitotic cell cycle Signaling by Hedgehog Association of licensing factors with the pre-replicative complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Ubiquitin Mediated Degradation of Phosphorylated Cdc25A TCF7L2 mutants don't bind CTBP p53-Dependent G1/S DNA damage checkpoint Signaling by Wnt Downregulation of SMAD2/3:SMAD4 transcriptional activity APC/C:Cdc20 mediated degradation of Securin AUF1 (hnRNP D0) destabilizes mRNA SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription CDK-mediated phosphorylation and removal of Cdc6 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer IRAK1 recruits IKK complex Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants RNF mutants show enhanced WNT signaling and proliferation Myoclonic epilepsy of Lafora Signaling by NOTCH1 in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer IRAK2 mediated activation of TAK1 complex SRP-dependent cotranslational protein targeting to membrane Loss of Function of SMAD4 in Cancer AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins Glycogen synthesis NRIF signals cell death from the nucleus Toll Like Receptor 4 (TLR4) Cascade Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by EGFR in Cancer SCF(Skp2)-mediated degradation of p27/p21 Cyclin A:Cdk2-associated events at S phase entry Constitutive Signaling by NOTCH1 PEST Domain Mutants Mitotic Metaphase and Anaphase Downstream TCR signaling Antigen processing: Ubiquitination & Proteasome degradation Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Toll Like Receptor 7/8 (TLR7/8) Cascade Orc1 removal from chromatin Mitotic Anaphase deactivation of the beta-catenin transactivating complex Toll Like Receptor TLR6:TLR2 Cascade MyD88 cascade initiated on plasma membrane Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 FBXW7 Mutants and NOTCH1 in Cancer Signalling by NGF Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Cytosolic sensors of pathogen-associated DNA beta-catenin independent WNT signaling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Orc1 removal from chromatin GTP hydrolysis and joining of the 60S ribosomal subunit Signaling by TGF-beta Receptor Complex CDT1 association with the CDC6:ORC:origin complex Antigen processing-Cross presentation ER-Phagosome pathway SMAD4 MH2 Domain Mutants in Cancer	Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by BMP Transcriptional regulation of pluripotent stem cells Generic Transcription Pathway Signaling by NODAL TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Signaling by Activin TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
UBA52 and SMAD2	ubiquitin A-52 residue ribosomal protein fusion product 1	SMAD family member 2	Loss of Function of TGFBR2 in Cancer NF-kB is activated and signals survival Hedgehog 'off' state Signaling by FGFR in disease Influenza Life Cycle Toll Like Receptor TLR1:TLR2 Cascade Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Glucose metabolism Signaling by NOTCH1 Signaling by NOTCH2 Toll Like Receptor 5 (TLR5) Cascade S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Stabilization of p53 Removal of licensing factors from origins Switching of origins to a post-replicative state Downregulation of ERBB2:ERBB3 signaling TGFBR2 MSI Frameshift Mutants in Cancer Signaling by NOTCH Endosomal Sorting Complex Required For Transport (ESCRT) Spry regulation of FGF signaling Influenza Infection Signaling by NOTCH SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Regulation of innate immune responses to cytosolic DNA Autodegradation of the E3 ubiquitin ligase COP1 Toll Like Receptor 3 (TLR3) Cascade Metabolism of carbohydrates CDK-mediated phosphorylation and removal of Cdc6 Cellular response to hypoxia Hedgehog ligand biogenesis p75NTR recruits signalling complexes Fanconi Anemia pathway Separation of Sister Chromatids APC truncation mutants have impaired AXIN binding HIV Infection Peptide chain elongation Assembly of the pre-replicative complex Activated TLR4 signalling Synthesis And Processing Of GAG, GAGPOL Polyproteins S37 mutants of beta-catenin aren't phosphorylated p53-Dependent G1 DNA Damage Response Signaling by NOTCH1 PEST Domain Mutants in Cancer regulation of FZD by ubiquitination Signaling by NOTCH1 p53-Independent DNA Damage Response MyD88:Mal cascade initiated on plasma membrane Stimuli-sensing channels p53-Independent G1/S DNA damage checkpoint Membrane binding and targetting of GAG proteins G1/S DNA Damage Checkpoints Downregulation of ERBB4 signaling Vpu mediated degradation of CD4 Cell death signalling via NRAGE, NRIF and NADE ISG15 antiviral mechanism Interferon Signaling Eukaryotic Translation Termination M/G1 Transition p75 NTR receptor-mediated signalling Signaling by FGFR Toll Like Receptor 10 (TLR10) Cascade Signaling by NOTCH1 in Cancer TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Degradation of GLI1 by the proteasome Cell Cycle Checkpoints degradation of DVL Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Downregulation of TGF-beta receptor signaling truncated APC mutants destabilize the destruction complex Cyclin E associated events during G1/S transition TGF-beta receptor signaling activates SMADs Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Generic Transcription Pathway Regulation of the Fanconi anemia pathway G1/S Transition FBXW7 Mutants and NOTCH1 in Cancer Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex truncations of AMER1 destabilize the destruction complex Negative regulation of FGFR signaling EGFR downregulation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Translation IRAK2 mediated activation of TAK1 complex Processing-defective Hh variants abrogate ligand secretion Regulation of activated PAK-2p34 by proteasome mediated degradation phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Host Interactions of HIV factors Signaling by ERBB4 Antiviral mechanism by IFN-stimulated genes Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex APC truncation mutants are not K63 polyubiquitinated M Phase Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon HIV Life Cycle Budding and maturation of HIV virion Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation IKK complex recruitment mediated by RIP1 MAP kinase activation in TLR cascade Regulation of DNA replication Cytokine Signaling in Immune system MyD88-independent cascade Signaling by Overexpressed Wild-Type EGFR in Cancer Viral mRNA Translation Cell Cycle, Mitotic Signaling by TGF-beta Receptor Complex in Cancer Oxidative Stress Induced Senescence Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Formation of a pool of free 40S subunits TRAF6 mediated induction of TAK1 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Negative regulators of RIG-I/MDA5 signaling misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease Cellular Senescence T41 mutants of beta-catenin aren't phosphorylated SMAD2/3 MH2 Domain Mutants in Cancer Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by EGFRvIII in Cancer Downstream signaling events of B Cell Receptor (BCR) Assembly Of The HIV Virion Degradation of beta-catenin by the destruction complex Influenza Viral RNA Transcription and Replication NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome Glycogen storage diseases Cap-dependent Translation Initiation Mitotic G1-G1/S phases activated TAK1 mediates p38 MAPK activation Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling DNA Replication Pre-Initiation Senescence-Associated Secretory Phenotype (SASP) S45 mutants of beta-catenin aren't phosphorylated APC/C:Cdc20 mediated degradation of mitotic proteins TGFBR1 KD Mutants in Cancer Regulation of APC/C activators between G1/S and early anaphase L13a-mediated translational silencing of Ceruloplasmin expression Late Phase of HIV Life Cycle APC/C:Cdc20 mediated degradation of Cyclin B NOTCH2 Activation and Transmission of Signal to the Nucleus Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) TCR signaling AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Interleukin-1 signaling Eukaryotic Translation Elongation PCP/CE pathway Mitotic G2-G2/M phases Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Adaptive Immune System APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Ubiquitin-dependent degradation of Cyclin D G2/M Transition Oncogene Induced Senescence TGFBR1 LBD Mutants in Cancer Autodegradation of Cdh1 by Cdh1:APC/C Ion channel transport Eukaryotic Translation Initiation p75NTR signals via NF-kB Regulation of signaling by CBL Disease XAV939 inhibits tankyrase, stabilizing AXIN TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Signal Transduction Innate Immune System Nonsense-Mediated Decay (NMD) Synthesis of DNA Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Signaling by Ligand-Responsive EGFR Variants in Cancer Loss of Function of TGFBR1 in Cancer Ubiquitin-dependent degradation of Cyclin D1 Activated NOTCH1 Transmits Signal to the Nucleus Toll-Like Receptors Cascades NOTCH1 Intracellular Domain Regulates Transcription Cyclin D associated events in G1 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Regulation of mitotic cell cycle Signaling by Hedgehog Association of licensing factors with the pre-replicative complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Ubiquitin Mediated Degradation of Phosphorylated Cdc25A TCF7L2 mutants don't bind CTBP p53-Dependent G1/S DNA damage checkpoint Signaling by Wnt Downregulation of SMAD2/3:SMAD4 transcriptional activity APC/C:Cdc20 mediated degradation of Securin AUF1 (hnRNP D0) destabilizes mRNA SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription CDK-mediated phosphorylation and removal of Cdc6 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer IRAK1 recruits IKK complex Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants RNF mutants show enhanced WNT signaling and proliferation Myoclonic epilepsy of Lafora Signaling by NOTCH1 in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer IRAK2 mediated activation of TAK1 complex SRP-dependent cotranslational protein targeting to membrane Loss of Function of SMAD4 in Cancer AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins Glycogen synthesis NRIF signals cell death from the nucleus Toll Like Receptor 4 (TLR4) Cascade Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by EGFR in Cancer SCF(Skp2)-mediated degradation of p27/p21 Cyclin A:Cdk2-associated events at S phase entry Constitutive Signaling by NOTCH1 PEST Domain Mutants Mitotic Metaphase and Anaphase Downstream TCR signaling Antigen processing: Ubiquitination & Proteasome degradation Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Toll Like Receptor 7/8 (TLR7/8) Cascade Orc1 removal from chromatin Mitotic Anaphase deactivation of the beta-catenin transactivating complex Toll Like Receptor TLR6:TLR2 Cascade MyD88 cascade initiated on plasma membrane Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 FBXW7 Mutants and NOTCH1 in Cancer Signalling by NGF Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Cytosolic sensors of pathogen-associated DNA beta-catenin independent WNT signaling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Orc1 removal from chromatin GTP hydrolysis and joining of the 60S ribosomal subunit Signaling by TGF-beta Receptor Complex CDT1 association with the CDC6:ORC:origin complex Antigen processing-Cross presentation ER-Phagosome pathway SMAD4 MH2 Domain Mutants in Cancer	Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Signaling by NODAL TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Signaling by Activin TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
UBA52 and TGFBR1	ubiquitin A-52 residue ribosomal protein fusion product 1	transforming growth factor, beta receptor 1	Loss of Function of TGFBR2 in Cancer NF-kB is activated and signals survival Hedgehog 'off' state Signaling by FGFR in disease Influenza Life Cycle Toll Like Receptor TLR1:TLR2 Cascade Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Glucose metabolism Signaling by NOTCH1 Signaling by NOTCH2 Toll Like Receptor 5 (TLR5) Cascade S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Stabilization of p53 Removal of licensing factors from origins Switching of origins to a post-replicative state Downregulation of ERBB2:ERBB3 signaling TGFBR2 MSI Frameshift Mutants in Cancer Signaling by NOTCH Endosomal Sorting Complex Required For Transport (ESCRT) Spry regulation of FGF signaling Influenza Infection Signaling by NOTCH SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Regulation of innate immune responses to cytosolic DNA Autodegradation of the E3 ubiquitin ligase COP1 Toll Like Receptor 3 (TLR3) Cascade Metabolism of carbohydrates CDK-mediated phosphorylation and removal of Cdc6 Cellular response to hypoxia Hedgehog ligand biogenesis p75NTR recruits signalling complexes Fanconi Anemia pathway Separation of Sister Chromatids APC truncation mutants have impaired AXIN binding HIV Infection Peptide chain elongation Assembly of the pre-replicative complex Activated TLR4 signalling Synthesis And Processing Of GAG, GAGPOL Polyproteins S37 mutants of beta-catenin aren't phosphorylated p53-Dependent G1 DNA Damage Response Signaling by NOTCH1 PEST Domain Mutants in Cancer regulation of FZD by ubiquitination Signaling by NOTCH1 p53-Independent DNA Damage Response MyD88:Mal cascade initiated on plasma membrane Stimuli-sensing channels p53-Independent G1/S DNA damage checkpoint Membrane binding and targetting of GAG proteins G1/S DNA Damage Checkpoints Downregulation of ERBB4 signaling Vpu mediated degradation of CD4 Cell death signalling via NRAGE, NRIF and NADE ISG15 antiviral mechanism Interferon Signaling Eukaryotic Translation Termination M/G1 Transition p75 NTR receptor-mediated signalling Signaling by FGFR Toll Like Receptor 10 (TLR10) Cascade Signaling by NOTCH1 in Cancer TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Degradation of GLI1 by the proteasome Cell Cycle Checkpoints degradation of DVL Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Downregulation of TGF-beta receptor signaling truncated APC mutants destabilize the destruction complex Cyclin E associated events during G1/S transition TGF-beta receptor signaling activates SMADs Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Generic Transcription Pathway Regulation of the Fanconi anemia pathway G1/S Transition FBXW7 Mutants and NOTCH1 in Cancer Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex truncations of AMER1 destabilize the destruction complex Negative regulation of FGFR signaling EGFR downregulation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Translation IRAK2 mediated activation of TAK1 complex Processing-defective Hh variants abrogate ligand secretion Regulation of activated PAK-2p34 by proteasome mediated degradation phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Host Interactions of HIV factors Signaling by ERBB4 Antiviral mechanism by IFN-stimulated genes Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex APC truncation mutants are not K63 polyubiquitinated M Phase Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon HIV Life Cycle Budding and maturation of HIV virion Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation IKK complex recruitment mediated by RIP1 MAP kinase activation in TLR cascade Regulation of DNA replication Cytokine Signaling in Immune system MyD88-independent cascade Signaling by Overexpressed Wild-Type EGFR in Cancer Viral mRNA Translation Cell Cycle, Mitotic Signaling by TGF-beta Receptor Complex in Cancer Oxidative Stress Induced Senescence Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Formation of a pool of free 40S subunits TRAF6 mediated induction of TAK1 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Negative regulators of RIG-I/MDA5 signaling misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease Cellular Senescence T41 mutants of beta-catenin aren't phosphorylated SMAD2/3 MH2 Domain Mutants in Cancer Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by EGFRvIII in Cancer Downstream signaling events of B Cell Receptor (BCR) Assembly Of The HIV Virion Degradation of beta-catenin by the destruction complex Influenza Viral RNA Transcription and Replication NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome Glycogen storage diseases Cap-dependent Translation Initiation Mitotic G1-G1/S phases activated TAK1 mediates p38 MAPK activation Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling DNA Replication Pre-Initiation Senescence-Associated Secretory Phenotype (SASP) S45 mutants of beta-catenin aren't phosphorylated APC/C:Cdc20 mediated degradation of mitotic proteins TGFBR1 KD Mutants in Cancer Regulation of APC/C activators between G1/S and early anaphase L13a-mediated translational silencing of Ceruloplasmin expression Late Phase of HIV Life Cycle APC/C:Cdc20 mediated degradation of Cyclin B NOTCH2 Activation and Transmission of Signal to the Nucleus Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) TCR signaling AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Interleukin-1 signaling Eukaryotic Translation Elongation PCP/CE pathway Mitotic G2-G2/M phases Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Adaptive Immune System APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Ubiquitin-dependent degradation of Cyclin D G2/M Transition Oncogene Induced Senescence TGFBR1 LBD Mutants in Cancer Autodegradation of Cdh1 by Cdh1:APC/C Ion channel transport Eukaryotic Translation Initiation p75NTR signals via NF-kB Regulation of signaling by CBL Disease XAV939 inhibits tankyrase, stabilizing AXIN TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Signal Transduction Innate Immune System Nonsense-Mediated Decay (NMD) Synthesis of DNA Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Signaling by Ligand-Responsive EGFR Variants in Cancer Loss of Function of TGFBR1 in Cancer Ubiquitin-dependent degradation of Cyclin D1 Activated NOTCH1 Transmits Signal to the Nucleus Toll-Like Receptors Cascades NOTCH1 Intracellular Domain Regulates Transcription Cyclin D associated events in G1 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Regulation of mitotic cell cycle Signaling by Hedgehog Association of licensing factors with the pre-replicative complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Ubiquitin Mediated Degradation of Phosphorylated Cdc25A TCF7L2 mutants don't bind CTBP p53-Dependent G1/S DNA damage checkpoint Signaling by Wnt Downregulation of SMAD2/3:SMAD4 transcriptional activity APC/C:Cdc20 mediated degradation of Securin AUF1 (hnRNP D0) destabilizes mRNA SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription CDK-mediated phosphorylation and removal of Cdc6 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer IRAK1 recruits IKK complex Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants RNF mutants show enhanced WNT signaling and proliferation Myoclonic epilepsy of Lafora Signaling by NOTCH1 in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer IRAK2 mediated activation of TAK1 complex SRP-dependent cotranslational protein targeting to membrane Loss of Function of SMAD4 in Cancer AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins Glycogen synthesis NRIF signals cell death from the nucleus Toll Like Receptor 4 (TLR4) Cascade Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by EGFR in Cancer SCF(Skp2)-mediated degradation of p27/p21 Cyclin A:Cdk2-associated events at S phase entry Constitutive Signaling by NOTCH1 PEST Domain Mutants Mitotic Metaphase and Anaphase Downstream TCR signaling Antigen processing: Ubiquitination & Proteasome degradation Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Toll Like Receptor 7/8 (TLR7/8) Cascade Orc1 removal from chromatin Mitotic Anaphase deactivation of the beta-catenin transactivating complex Toll Like Receptor TLR6:TLR2 Cascade MyD88 cascade initiated on plasma membrane Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 FBXW7 Mutants and NOTCH1 in Cancer Signalling by NGF Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Cytosolic sensors of pathogen-associated DNA beta-catenin independent WNT signaling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Orc1 removal from chromatin GTP hydrolysis and joining of the 60S ribosomal subunit Signaling by TGF-beta Receptor Complex CDT1 association with the CDC6:ORC:origin complex Antigen processing-Cross presentation ER-Phagosome pathway SMAD4 MH2 Domain Mutants in Cancer	Loss of Function of TGFBR2 in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
UBA52 and HGS	ubiquitin A-52 residue ribosomal protein fusion product 1	hepatocyte growth factor-regulated tyrosine kinase substrate	Loss of Function of TGFBR2 in Cancer NF-kB is activated and signals survival Hedgehog 'off' state Signaling by FGFR in disease Influenza Life Cycle Toll Like Receptor TLR1:TLR2 Cascade Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Glucose metabolism Signaling by NOTCH1 Signaling by NOTCH2 Toll Like Receptor 5 (TLR5) Cascade S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Stabilization of p53 Removal of licensing factors from origins Switching of origins to a post-replicative state Downregulation of ERBB2:ERBB3 signaling TGFBR2 MSI Frameshift Mutants in Cancer Signaling by NOTCH Endosomal Sorting Complex Required For Transport (ESCRT) Spry regulation of FGF signaling Influenza Infection Signaling by NOTCH SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Regulation of innate immune responses to cytosolic DNA Autodegradation of the E3 ubiquitin ligase COP1 Toll Like Receptor 3 (TLR3) Cascade Metabolism of carbohydrates CDK-mediated phosphorylation and removal of Cdc6 Cellular response to hypoxia Hedgehog ligand biogenesis p75NTR recruits signalling complexes Fanconi Anemia pathway Separation of Sister Chromatids APC truncation mutants have impaired AXIN binding HIV Infection Peptide chain elongation Assembly of the pre-replicative complex Activated TLR4 signalling Synthesis And Processing Of GAG, GAGPOL Polyproteins S37 mutants of beta-catenin aren't phosphorylated p53-Dependent G1 DNA Damage Response Signaling by NOTCH1 PEST Domain Mutants in Cancer regulation of FZD by ubiquitination Signaling by NOTCH1 p53-Independent DNA Damage Response MyD88:Mal cascade initiated on plasma membrane Stimuli-sensing channels p53-Independent G1/S DNA damage checkpoint Membrane binding and targetting of GAG proteins G1/S DNA Damage Checkpoints Downregulation of ERBB4 signaling Vpu mediated degradation of CD4 Cell death signalling via NRAGE, NRIF and NADE ISG15 antiviral mechanism Interferon Signaling Eukaryotic Translation Termination M/G1 Transition p75 NTR receptor-mediated signalling Signaling by FGFR Toll Like Receptor 10 (TLR10) Cascade Signaling by NOTCH1 in Cancer TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Degradation of GLI1 by the proteasome Cell Cycle Checkpoints degradation of DVL Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Downregulation of TGF-beta receptor signaling truncated APC mutants destabilize the destruction complex Cyclin E associated events during G1/S transition TGF-beta receptor signaling activates SMADs Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Generic Transcription Pathway Regulation of the Fanconi anemia pathway G1/S Transition FBXW7 Mutants and NOTCH1 in Cancer Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex truncations of AMER1 destabilize the destruction complex Negative regulation of FGFR signaling EGFR downregulation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Translation IRAK2 mediated activation of TAK1 complex Processing-defective Hh variants abrogate ligand secretion Regulation of activated PAK-2p34 by proteasome mediated degradation phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Host Interactions of HIV factors Signaling by ERBB4 Antiviral mechanism by IFN-stimulated genes Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex APC truncation mutants are not K63 polyubiquitinated M Phase Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon HIV Life Cycle Budding and maturation of HIV virion Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation IKK complex recruitment mediated by RIP1 MAP kinase activation in TLR cascade Regulation of DNA replication Cytokine Signaling in Immune system MyD88-independent cascade Signaling by Overexpressed Wild-Type EGFR in Cancer Viral mRNA Translation Cell Cycle, Mitotic Signaling by TGF-beta Receptor Complex in Cancer Oxidative Stress Induced Senescence Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Formation of a pool of free 40S subunits TRAF6 mediated induction of TAK1 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Negative regulators of RIG-I/MDA5 signaling misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease Cellular Senescence T41 mutants of beta-catenin aren't phosphorylated SMAD2/3 MH2 Domain Mutants in Cancer Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by EGFRvIII in Cancer Downstream signaling events of B Cell Receptor (BCR) Assembly Of The HIV Virion Degradation of beta-catenin by the destruction complex Influenza Viral RNA Transcription and Replication NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome Glycogen storage diseases Cap-dependent Translation Initiation Mitotic G1-G1/S phases activated TAK1 mediates p38 MAPK activation Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling DNA Replication Pre-Initiation Senescence-Associated Secretory Phenotype (SASP) S45 mutants of beta-catenin aren't phosphorylated APC/C:Cdc20 mediated degradation of mitotic proteins TGFBR1 KD Mutants in Cancer Regulation of APC/C activators between G1/S and early anaphase L13a-mediated translational silencing of Ceruloplasmin expression Late Phase of HIV Life Cycle APC/C:Cdc20 mediated degradation of Cyclin B NOTCH2 Activation and Transmission of Signal to the Nucleus Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) TCR signaling AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Interleukin-1 signaling Eukaryotic Translation Elongation PCP/CE pathway Mitotic G2-G2/M phases Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Adaptive Immune System APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Ubiquitin-dependent degradation of Cyclin D G2/M Transition Oncogene Induced Senescence TGFBR1 LBD Mutants in Cancer Autodegradation of Cdh1 by Cdh1:APC/C Ion channel transport Eukaryotic Translation Initiation p75NTR signals via NF-kB Regulation of signaling by CBL Disease XAV939 inhibits tankyrase, stabilizing AXIN TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Signal Transduction Innate Immune System Nonsense-Mediated Decay (NMD) Synthesis of DNA Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Signaling by Ligand-Responsive EGFR Variants in Cancer Loss of Function of TGFBR1 in Cancer Ubiquitin-dependent degradation of Cyclin D1 Activated NOTCH1 Transmits Signal to the Nucleus Toll-Like Receptors Cascades NOTCH1 Intracellular Domain Regulates Transcription Cyclin D associated events in G1 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Regulation of mitotic cell cycle Signaling by Hedgehog Association of licensing factors with the pre-replicative complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Ubiquitin Mediated Degradation of Phosphorylated Cdc25A TCF7L2 mutants don't bind CTBP p53-Dependent G1/S DNA damage checkpoint Signaling by Wnt Downregulation of SMAD2/3:SMAD4 transcriptional activity APC/C:Cdc20 mediated degradation of Securin AUF1 (hnRNP D0) destabilizes mRNA SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription CDK-mediated phosphorylation and removal of Cdc6 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer IRAK1 recruits IKK complex Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants RNF mutants show enhanced WNT signaling and proliferation Myoclonic epilepsy of Lafora Signaling by NOTCH1 in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer IRAK2 mediated activation of TAK1 complex SRP-dependent cotranslational protein targeting to membrane Loss of Function of SMAD4 in Cancer AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins Glycogen synthesis NRIF signals cell death from the nucleus Toll Like Receptor 4 (TLR4) Cascade Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by EGFR in Cancer SCF(Skp2)-mediated degradation of p27/p21 Cyclin A:Cdk2-associated events at S phase entry Constitutive Signaling by NOTCH1 PEST Domain Mutants Mitotic Metaphase and Anaphase Downstream TCR signaling Antigen processing: Ubiquitination & Proteasome degradation Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Toll Like Receptor 7/8 (TLR7/8) Cascade Orc1 removal from chromatin Mitotic Anaphase deactivation of the beta-catenin transactivating complex Toll Like Receptor TLR6:TLR2 Cascade MyD88 cascade initiated on plasma membrane Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 FBXW7 Mutants and NOTCH1 in Cancer Signalling by NGF Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Cytosolic sensors of pathogen-associated DNA beta-catenin independent WNT signaling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Orc1 removal from chromatin GTP hydrolysis and joining of the 60S ribosomal subunit Signaling by TGF-beta Receptor Complex CDT1 association with the CDC6:ORC:origin complex Antigen processing-Cross presentation ER-Phagosome pathway SMAD4 MH2 Domain Mutants in Cancer	Signaling by EGFR EGFR downregulation Endosomal Sorting Complex Required For Transport (ESCRT) Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
UBB and MYC	ubiquitin B	v-myc avian myelocytomatosis viral oncogene homolog	Loss of Function of TGFBR2 in Cancer NF-kB is activated and signals survival Signaling by FGFR in disease Hedgehog 'off' state Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Glucose metabolism Toll Like Receptor TLR1:TLR2 Cascade Signaling by NOTCH1 Signaling by NOTCH2 Toll Like Receptor 5 (TLR5) Cascade AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated Stabilization of p53 Removal of licensing factors from origins Switching of origins to a post-replicative state Downregulation of ERBB2:ERBB3 signaling TGFBR2 MSI Frameshift Mutants in Cancer Signaling by NOTCH Endosomal Sorting Complex Required For Transport (ESCRT) Spry regulation of FGF signaling Signaling by NOTCH SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Regulation of innate immune responses to cytosolic DNA Autodegradation of the E3 ubiquitin ligase COP1 Toll Like Receptor 3 (TLR3) Cascade Metabolism of carbohydrates CDK-mediated phosphorylation and removal of Cdc6 Cellular response to hypoxia Hedgehog ligand biogenesis p75NTR recruits signalling complexes Fanconi Anemia pathway Separation of Sister Chromatids HIV Infection APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Synthesis And Processing Of GAG, GAGPOL Polyproteins Activated TLR4 signalling S37 mutants of beta-catenin aren't phosphorylated p53-Dependent G1 DNA Damage Response regulation of FZD by ubiquitination Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 p53-Independent DNA Damage Response MyD88:Mal cascade initiated on plasma membrane Stimuli-sensing channels Membrane binding and targetting of GAG proteins p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Downregulation of ERBB4 signaling Vpu mediated degradation of CD4 Cell death signalling via NRAGE, NRIF and NADE ISG15 antiviral mechanism Interferon Signaling M/G1 Transition p75 NTR receptor-mediated signalling Signaling by FGFR Toll Like Receptor 10 (TLR10) Cascade Signaling by NOTCH1 in Cancer TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Downregulation of TGF-beta receptor signaling truncated APC mutants destabilize the destruction complex Cyclin E associated events during G1/S transition TGF-beta receptor signaling activates SMADs Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Regulation of the Fanconi anemia pathway Generic Transcription Pathway G1/S Transition Toll Like Receptor 9 (TLR9) Cascade FBXW7 Mutants and NOTCH1 in Cancer IRAK1 recruits IKK complex Negative regulation of FGFR signaling truncations of AMER1 destabilize the destruction complex EGFR downregulation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) IRAK2 mediated activation of TAK1 complex Processing-defective Hh variants abrogate ligand secretion Regulation of activated PAK-2p34 by proteasome mediated degradation Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Signaling by ERBB4 Antiviral mechanism by IFN-stimulated genes Fc epsilon receptor (FCERI) signaling Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Interleukin-3, 5 and GM-CSF signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex M Phase APC truncation mutants are not K63 polyubiquitinated Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon HIV Life Cycle Budding and maturation of HIV virion Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation IKK complex recruitment mediated by RIP1 MAP kinase activation in TLR cascade Regulation of DNA replication Cytokine Signaling in Immune system Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell Cycle, Mitotic Signaling by TGF-beta Receptor Complex in Cancer Oxidative Stress Induced Senescence Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation TRAF6 mediated induction of TAK1 complex Negative regulators of RIG-I/MDA5 signaling misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease SMAD2/3 MH2 Domain Mutants in Cancer T41 mutants of beta-catenin aren't phosphorylated Cellular Senescence Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by EGFRvIII in Cancer Assembly Of The HIV Virion Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex NOD1/2 Signaling Pathway Glycogen storage diseases MyD88 dependent cascade initiated on endosome Mitotic G1-G1/S phases activated TAK1 mediates p38 MAPK activation Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling DNA Replication Pre-Initiation Senescence-Associated Secretory Phenotype (SASP) APC/C:Cdc20 mediated degradation of mitotic proteins TGFBR1 KD Mutants in Cancer S45 mutants of beta-catenin aren't phosphorylated Regulation of APC/C activators between G1/S and early anaphase Late Phase of HIV Life Cycle APC/C:Cdc20 mediated degradation of Cyclin B NOTCH2 Activation and Transmission of Signal to the Nucleus TCR signaling AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Interleukin-1 signaling APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Mitotic G2-G2/M phases Adaptive Immune System APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Ubiquitin-dependent degradation of Cyclin D G2/M Transition TGFBR1 LBD Mutants in Cancer Oncogene Induced Senescence Autodegradation of Cdh1 by Cdh1:APC/C Ion channel transport p75NTR signals via NF-kB Regulation of signaling by CBL XAV939 inhibits tankyrase, stabilizing AXIN Disease TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Signal Transduction Innate Immune System Synthesis of DNA Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Signaling by Ligand-Responsive EGFR Variants in Cancer Loss of Function of TGFBR1 in Cancer Ubiquitin-dependent degradation of Cyclin D1 Activated NOTCH1 Transmits Signal to the Nucleus NOTCH1 Intracellular Domain Regulates Transcription Toll-Like Receptors Cascades Cyclin D associated events in G1 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Regulation of mitotic cell cycle Signaling by Hedgehog Association of licensing factors with the pre-replicative complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Ubiquitin Mediated Degradation of Phosphorylated Cdc25A TCF7L2 mutants don't bind CTBP p53-Dependent G1/S DNA damage checkpoint Signaling by Wnt AUF1 (hnRNP D0) destabilizes mRNA Downregulation of SMAD2/3:SMAD4 transcriptional activity APC/C:Cdc20 mediated degradation of Securin SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription CDK-mediated phosphorylation and removal of Cdc6 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer IRAK1 recruits IKK complex Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants RNF mutants show enhanced WNT signaling and proliferation Myoclonic epilepsy of Lafora Signaling by NOTCH1 in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer IRAK2 mediated activation of TAK1 complex Loss of Function of SMAD4 in Cancer AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins Glycogen synthesis NRIF signals cell death from the nucleus Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Signaling by NOTCH1 PEST Domain Mutants in Cancer SCF(Skp2)-mediated degradation of p27/p21 Cyclin A:Cdk2-associated events at S phase entry Constitutive Signaling by NOTCH1 PEST Domain Mutants Mitotic Metaphase and Anaphase Downstream TCR signaling Antigen processing: Ubiquitination & Proteasome degradation Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Toll Like Receptor 7/8 (TLR7/8) Cascade Orc1 removal from chromatin Mitotic Anaphase deactivation of the beta-catenin transactivating complex Toll Like Receptor TLR6:TLR2 Cascade MyD88 cascade initiated on plasma membrane Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Signalling by NGF Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Cytosolic sensors of pathogen-associated DNA beta-catenin independent WNT signaling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Orc1 removal from chromatin Signaling by TGF-beta Receptor Complex CDT1 association with the CDC6:ORC:origin complex Antigen processing-Cross presentation ER-Phagosome pathway SMAD4 MH2 Domain Mutants in Cancer	Loss of Function of TGFBR2 in Cancer Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Signaling by Wnt Cyclin E associated events during G1/S transition binding of TCF/LEF:CTNNB1 to target gene promoters TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway RNF mutants show enhanced WNT signaling and proliferation G1/S Transition Signaling by NOTCH1 XAV939 inhibits tankyrase, stabilizing AXIN Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Mitotic G1-G1/S phases FBXW7 Mutants and NOTCH1 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Loss of Function of SMAD2/3 in Cancer Signaling by NOTCH formation of the beta-catenin:TCF transactivating complex TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer S Phase Cell Cycle, Mitotic Loss of Function of TGFBR1 in Cancer NOTCH1 Intracellular Domain Regulates Transcription Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex TCF dependent signaling in response to WNT Signaling by NOTCH1 PEST Domain Mutants in Cancer Cyclin A:Cdk2-associated events at S phase entry Signaling by WNT in cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants SMAD4 MH2 Domain Mutants in Cancer
UBB and SMAD4	ubiquitin B	SMAD family member 4	Loss of Function of TGFBR2 in Cancer NF-kB is activated and signals survival Signaling by FGFR in disease Hedgehog 'off' state Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Glucose metabolism Toll Like Receptor TLR1:TLR2 Cascade Signaling by NOTCH1 Signaling by NOTCH2 Toll Like Receptor 5 (TLR5) Cascade AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated Stabilization of p53 Removal of licensing factors from origins Switching of origins to a post-replicative state Downregulation of ERBB2:ERBB3 signaling TGFBR2 MSI Frameshift Mutants in Cancer Signaling by NOTCH Endosomal Sorting Complex Required For Transport (ESCRT) Spry regulation of FGF signaling Signaling by NOTCH SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Regulation of innate immune responses to cytosolic DNA Autodegradation of the E3 ubiquitin ligase COP1 Toll Like Receptor 3 (TLR3) Cascade Metabolism of carbohydrates CDK-mediated phosphorylation and removal of Cdc6 Cellular response to hypoxia Hedgehog ligand biogenesis p75NTR recruits signalling complexes Fanconi Anemia pathway Separation of Sister Chromatids HIV Infection APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Synthesis And Processing Of GAG, GAGPOL Polyproteins Activated TLR4 signalling S37 mutants of beta-catenin aren't phosphorylated p53-Dependent G1 DNA Damage Response regulation of FZD by ubiquitination Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 p53-Independent DNA Damage Response MyD88:Mal cascade initiated on plasma membrane Stimuli-sensing channels Membrane binding and targetting of GAG proteins p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Downregulation of ERBB4 signaling Vpu mediated degradation of CD4 Cell death signalling via NRAGE, NRIF and NADE ISG15 antiviral mechanism Interferon Signaling M/G1 Transition p75 NTR receptor-mediated signalling Signaling by FGFR Toll Like Receptor 10 (TLR10) Cascade Signaling by NOTCH1 in Cancer TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Downregulation of TGF-beta receptor signaling truncated APC mutants destabilize the destruction complex Cyclin E associated events during G1/S transition TGF-beta receptor signaling activates SMADs Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Regulation of the Fanconi anemia pathway Generic Transcription Pathway G1/S Transition Toll Like Receptor 9 (TLR9) Cascade FBXW7 Mutants and NOTCH1 in Cancer IRAK1 recruits IKK complex Negative regulation of FGFR signaling truncations of AMER1 destabilize the destruction complex EGFR downregulation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) IRAK2 mediated activation of TAK1 complex Processing-defective Hh variants abrogate ligand secretion Regulation of activated PAK-2p34 by proteasome mediated degradation Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Signaling by ERBB4 Antiviral mechanism by IFN-stimulated genes Fc epsilon receptor (FCERI) signaling Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Interleukin-3, 5 and GM-CSF signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex M Phase APC truncation mutants are not K63 polyubiquitinated Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon HIV Life Cycle Budding and maturation of HIV virion Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation IKK complex recruitment mediated by RIP1 MAP kinase activation in TLR cascade Regulation of DNA replication Cytokine Signaling in Immune system Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell Cycle, Mitotic Signaling by TGF-beta Receptor Complex in Cancer Oxidative Stress Induced Senescence Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation TRAF6 mediated induction of TAK1 complex Negative regulators of RIG-I/MDA5 signaling misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease SMAD2/3 MH2 Domain Mutants in Cancer T41 mutants of beta-catenin aren't phosphorylated Cellular Senescence Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by EGFRvIII in Cancer Assembly Of The HIV Virion Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex NOD1/2 Signaling Pathway Glycogen storage diseases MyD88 dependent cascade initiated on endosome Mitotic G1-G1/S phases activated TAK1 mediates p38 MAPK activation Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling DNA Replication Pre-Initiation Senescence-Associated Secretory Phenotype (SASP) APC/C:Cdc20 mediated degradation of mitotic proteins TGFBR1 KD Mutants in Cancer S45 mutants of beta-catenin aren't phosphorylated Regulation of APC/C activators between G1/S and early anaphase Late Phase of HIV Life Cycle APC/C:Cdc20 mediated degradation of Cyclin B NOTCH2 Activation and Transmission of Signal to the Nucleus TCR signaling AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Interleukin-1 signaling APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Mitotic G2-G2/M phases Adaptive Immune System APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Ubiquitin-dependent degradation of Cyclin D G2/M Transition TGFBR1 LBD Mutants in Cancer Oncogene Induced Senescence Autodegradation of Cdh1 by Cdh1:APC/C Ion channel transport p75NTR signals via NF-kB Regulation of signaling by CBL XAV939 inhibits tankyrase, stabilizing AXIN Disease TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Signal Transduction Innate Immune System Synthesis of DNA Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Signaling by Ligand-Responsive EGFR Variants in Cancer Loss of Function of TGFBR1 in Cancer Ubiquitin-dependent degradation of Cyclin D1 Activated NOTCH1 Transmits Signal to the Nucleus NOTCH1 Intracellular Domain Regulates Transcription Toll-Like Receptors Cascades Cyclin D associated events in G1 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Regulation of mitotic cell cycle Signaling by Hedgehog Association of licensing factors with the pre-replicative complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Ubiquitin Mediated Degradation of Phosphorylated Cdc25A TCF7L2 mutants don't bind CTBP p53-Dependent G1/S DNA damage checkpoint Signaling by Wnt AUF1 (hnRNP D0) destabilizes mRNA Downregulation of SMAD2/3:SMAD4 transcriptional activity APC/C:Cdc20 mediated degradation of Securin SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription CDK-mediated phosphorylation and removal of Cdc6 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer IRAK1 recruits IKK complex Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants RNF mutants show enhanced WNT signaling and proliferation Myoclonic epilepsy of Lafora Signaling by NOTCH1 in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer IRAK2 mediated activation of TAK1 complex Loss of Function of SMAD4 in Cancer AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins Glycogen synthesis NRIF signals cell death from the nucleus Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Signaling by NOTCH1 PEST Domain Mutants in Cancer SCF(Skp2)-mediated degradation of p27/p21 Cyclin A:Cdk2-associated events at S phase entry Constitutive Signaling by NOTCH1 PEST Domain Mutants Mitotic Metaphase and Anaphase Downstream TCR signaling Antigen processing: Ubiquitination & Proteasome degradation Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Toll Like Receptor 7/8 (TLR7/8) Cascade Orc1 removal from chromatin Mitotic Anaphase deactivation of the beta-catenin transactivating complex Toll Like Receptor TLR6:TLR2 Cascade MyD88 cascade initiated on plasma membrane Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Signalling by NGF Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Cytosolic sensors of pathogen-associated DNA beta-catenin independent WNT signaling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Orc1 removal from chromatin Signaling by TGF-beta Receptor Complex CDT1 association with the CDC6:ORC:origin complex Antigen processing-Cross presentation ER-Phagosome pathway SMAD4 MH2 Domain Mutants in Cancer	Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by BMP Transcriptional regulation of pluripotent stem cells Generic Transcription Pathway Signaling by NODAL TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Signaling by Activin TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
UBB and TGFBR1	ubiquitin B	transforming growth factor, beta receptor 1	Loss of Function of TGFBR2 in Cancer NF-kB is activated and signals survival Signaling by FGFR in disease Hedgehog 'off' state Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Glucose metabolism Toll Like Receptor TLR1:TLR2 Cascade Signaling by NOTCH1 Signaling by NOTCH2 Toll Like Receptor 5 (TLR5) Cascade AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated Stabilization of p53 Removal of licensing factors from origins Switching of origins to a post-replicative state Downregulation of ERBB2:ERBB3 signaling TGFBR2 MSI Frameshift Mutants in Cancer Signaling by NOTCH Endosomal Sorting Complex Required For Transport (ESCRT) Spry regulation of FGF signaling Signaling by NOTCH SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Regulation of innate immune responses to cytosolic DNA Autodegradation of the E3 ubiquitin ligase COP1 Toll Like Receptor 3 (TLR3) Cascade Metabolism of carbohydrates CDK-mediated phosphorylation and removal of Cdc6 Cellular response to hypoxia Hedgehog ligand biogenesis p75NTR recruits signalling complexes Fanconi Anemia pathway Separation of Sister Chromatids HIV Infection APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Synthesis And Processing Of GAG, GAGPOL Polyproteins Activated TLR4 signalling S37 mutants of beta-catenin aren't phosphorylated p53-Dependent G1 DNA Damage Response regulation of FZD by ubiquitination Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 p53-Independent DNA Damage Response MyD88:Mal cascade initiated on plasma membrane Stimuli-sensing channels Membrane binding and targetting of GAG proteins p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Downregulation of ERBB4 signaling Vpu mediated degradation of CD4 Cell death signalling via NRAGE, NRIF and NADE ISG15 antiviral mechanism Interferon Signaling M/G1 Transition p75 NTR receptor-mediated signalling Signaling by FGFR Toll Like Receptor 10 (TLR10) Cascade Signaling by NOTCH1 in Cancer TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Downregulation of TGF-beta receptor signaling truncated APC mutants destabilize the destruction complex Cyclin E associated events during G1/S transition TGF-beta receptor signaling activates SMADs Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Regulation of the Fanconi anemia pathway Generic Transcription Pathway G1/S Transition Toll Like Receptor 9 (TLR9) Cascade FBXW7 Mutants and NOTCH1 in Cancer IRAK1 recruits IKK complex Negative regulation of FGFR signaling truncations of AMER1 destabilize the destruction complex EGFR downregulation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) IRAK2 mediated activation of TAK1 complex Processing-defective Hh variants abrogate ligand secretion Regulation of activated PAK-2p34 by proteasome mediated degradation Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Signaling by ERBB4 Antiviral mechanism by IFN-stimulated genes Fc epsilon receptor (FCERI) signaling Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Interleukin-3, 5 and GM-CSF signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex M Phase APC truncation mutants are not K63 polyubiquitinated Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon HIV Life Cycle Budding and maturation of HIV virion Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation IKK complex recruitment mediated by RIP1 MAP kinase activation in TLR cascade Regulation of DNA replication Cytokine Signaling in Immune system Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell Cycle, Mitotic Signaling by TGF-beta Receptor Complex in Cancer Oxidative Stress Induced Senescence Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation TRAF6 mediated induction of TAK1 complex Negative regulators of RIG-I/MDA5 signaling misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease SMAD2/3 MH2 Domain Mutants in Cancer T41 mutants of beta-catenin aren't phosphorylated Cellular Senescence Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by EGFRvIII in Cancer Assembly Of The HIV Virion Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex NOD1/2 Signaling Pathway Glycogen storage diseases MyD88 dependent cascade initiated on endosome Mitotic G1-G1/S phases activated TAK1 mediates p38 MAPK activation Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling DNA Replication Pre-Initiation Senescence-Associated Secretory Phenotype (SASP) APC/C:Cdc20 mediated degradation of mitotic proteins TGFBR1 KD Mutants in Cancer S45 mutants of beta-catenin aren't phosphorylated Regulation of APC/C activators between G1/S and early anaphase Late Phase of HIV Life Cycle APC/C:Cdc20 mediated degradation of Cyclin B NOTCH2 Activation and Transmission of Signal to the Nucleus TCR signaling AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Interleukin-1 signaling APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Mitotic G2-G2/M phases Adaptive Immune System APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Ubiquitin-dependent degradation of Cyclin D G2/M Transition TGFBR1 LBD Mutants in Cancer Oncogene Induced Senescence Autodegradation of Cdh1 by Cdh1:APC/C Ion channel transport p75NTR signals via NF-kB Regulation of signaling by CBL XAV939 inhibits tankyrase, stabilizing AXIN Disease TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Signal Transduction Innate Immune System Synthesis of DNA Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Signaling by Ligand-Responsive EGFR Variants in Cancer Loss of Function of TGFBR1 in Cancer Ubiquitin-dependent degradation of Cyclin D1 Activated NOTCH1 Transmits Signal to the Nucleus NOTCH1 Intracellular Domain Regulates Transcription Toll-Like Receptors Cascades Cyclin D associated events in G1 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Regulation of mitotic cell cycle Signaling by Hedgehog Association of licensing factors with the pre-replicative complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Ubiquitin Mediated Degradation of Phosphorylated Cdc25A TCF7L2 mutants don't bind CTBP p53-Dependent G1/S DNA damage checkpoint Signaling by Wnt AUF1 (hnRNP D0) destabilizes mRNA Downregulation of SMAD2/3:SMAD4 transcriptional activity APC/C:Cdc20 mediated degradation of Securin SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription CDK-mediated phosphorylation and removal of Cdc6 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer IRAK1 recruits IKK complex Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants RNF mutants show enhanced WNT signaling and proliferation Myoclonic epilepsy of Lafora Signaling by NOTCH1 in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer IRAK2 mediated activation of TAK1 complex Loss of Function of SMAD4 in Cancer AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins Glycogen synthesis NRIF signals cell death from the nucleus Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Signaling by NOTCH1 PEST Domain Mutants in Cancer SCF(Skp2)-mediated degradation of p27/p21 Cyclin A:Cdk2-associated events at S phase entry Constitutive Signaling by NOTCH1 PEST Domain Mutants Mitotic Metaphase and Anaphase Downstream TCR signaling Antigen processing: Ubiquitination & Proteasome degradation Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Toll Like Receptor 7/8 (TLR7/8) Cascade Orc1 removal from chromatin Mitotic Anaphase deactivation of the beta-catenin transactivating complex Toll Like Receptor TLR6:TLR2 Cascade MyD88 cascade initiated on plasma membrane Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Signalling by NGF Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Cytosolic sensors of pathogen-associated DNA beta-catenin independent WNT signaling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Orc1 removal from chromatin Signaling by TGF-beta Receptor Complex CDT1 association with the CDC6:ORC:origin complex Antigen processing-Cross presentation ER-Phagosome pathway SMAD4 MH2 Domain Mutants in Cancer	Loss of Function of TGFBR2 in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
UBB and NTRK1	ubiquitin B	neurotrophic tyrosine kinase, receptor, type 1	Loss of Function of TGFBR2 in Cancer NF-kB is activated and signals survival Signaling by FGFR in disease Hedgehog 'off' state Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Glucose metabolism Toll Like Receptor TLR1:TLR2 Cascade Signaling by NOTCH1 Signaling by NOTCH2 Toll Like Receptor 5 (TLR5) Cascade AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated Stabilization of p53 Removal of licensing factors from origins Switching of origins to a post-replicative state Downregulation of ERBB2:ERBB3 signaling TGFBR2 MSI Frameshift Mutants in Cancer Signaling by NOTCH Endosomal Sorting Complex Required For Transport (ESCRT) Spry regulation of FGF signaling Signaling by NOTCH SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Regulation of innate immune responses to cytosolic DNA Autodegradation of the E3 ubiquitin ligase COP1 Toll Like Receptor 3 (TLR3) Cascade Metabolism of carbohydrates CDK-mediated phosphorylation and removal of Cdc6 Cellular response to hypoxia Hedgehog ligand biogenesis p75NTR recruits signalling complexes Fanconi Anemia pathway Separation of Sister Chromatids HIV Infection APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Synthesis And Processing Of GAG, GAGPOL Polyproteins Activated TLR4 signalling S37 mutants of beta-catenin aren't phosphorylated p53-Dependent G1 DNA Damage Response regulation of FZD by ubiquitination Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 p53-Independent DNA Damage Response MyD88:Mal cascade initiated on plasma membrane Stimuli-sensing channels Membrane binding and targetting of GAG proteins p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Downregulation of ERBB4 signaling Vpu mediated degradation of CD4 Cell death signalling via NRAGE, NRIF and NADE ISG15 antiviral mechanism Interferon Signaling M/G1 Transition p75 NTR receptor-mediated signalling Signaling by FGFR Toll Like Receptor 10 (TLR10) Cascade Signaling by NOTCH1 in Cancer TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Downregulation of TGF-beta receptor signaling truncated APC mutants destabilize the destruction complex Cyclin E associated events during G1/S transition TGF-beta receptor signaling activates SMADs Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Regulation of the Fanconi anemia pathway Generic Transcription Pathway G1/S Transition Toll Like Receptor 9 (TLR9) Cascade FBXW7 Mutants and NOTCH1 in Cancer IRAK1 recruits IKK complex Negative regulation of FGFR signaling truncations of AMER1 destabilize the destruction complex EGFR downregulation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) IRAK2 mediated activation of TAK1 complex Processing-defective Hh variants abrogate ligand secretion Regulation of activated PAK-2p34 by proteasome mediated degradation Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Signaling by ERBB4 Antiviral mechanism by IFN-stimulated genes Fc epsilon receptor (FCERI) signaling Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Interleukin-3, 5 and GM-CSF signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex M Phase APC truncation mutants are not K63 polyubiquitinated Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon HIV Life Cycle Budding and maturation of HIV virion Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation IKK complex recruitment mediated by RIP1 MAP kinase activation in TLR cascade Regulation of DNA replication Cytokine Signaling in Immune system Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell Cycle, Mitotic Signaling by TGF-beta Receptor Complex in Cancer Oxidative Stress Induced Senescence Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation TRAF6 mediated induction of TAK1 complex Negative regulators of RIG-I/MDA5 signaling misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease SMAD2/3 MH2 Domain Mutants in Cancer T41 mutants of beta-catenin aren't phosphorylated Cellular Senescence Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by EGFRvIII in Cancer Assembly Of The HIV Virion Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex NOD1/2 Signaling Pathway Glycogen storage diseases MyD88 dependent cascade initiated on endosome Mitotic G1-G1/S phases activated TAK1 mediates p38 MAPK activation Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling DNA Replication Pre-Initiation Senescence-Associated Secretory Phenotype (SASP) APC/C:Cdc20 mediated degradation of mitotic proteins TGFBR1 KD Mutants in Cancer S45 mutants of beta-catenin aren't phosphorylated Regulation of APC/C activators between G1/S and early anaphase Late Phase of HIV Life Cycle APC/C:Cdc20 mediated degradation of Cyclin B NOTCH2 Activation and Transmission of Signal to the Nucleus TCR signaling AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Interleukin-1 signaling APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Mitotic G2-G2/M phases Adaptive Immune System APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Ubiquitin-dependent degradation of Cyclin D G2/M Transition TGFBR1 LBD Mutants in Cancer Oncogene Induced Senescence Autodegradation of Cdh1 by Cdh1:APC/C Ion channel transport p75NTR signals via NF-kB Regulation of signaling by CBL XAV939 inhibits tankyrase, stabilizing AXIN Disease TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Signal Transduction Innate Immune System Synthesis of DNA Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Signaling by Ligand-Responsive EGFR Variants in Cancer Loss of Function of TGFBR1 in Cancer Ubiquitin-dependent degradation of Cyclin D1 Activated NOTCH1 Transmits Signal to the Nucleus NOTCH1 Intracellular Domain Regulates Transcription Toll-Like Receptors Cascades Cyclin D associated events in G1 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Regulation of mitotic cell cycle Signaling by Hedgehog Association of licensing factors with the pre-replicative complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Ubiquitin Mediated Degradation of Phosphorylated Cdc25A TCF7L2 mutants don't bind CTBP p53-Dependent G1/S DNA damage checkpoint Signaling by Wnt AUF1 (hnRNP D0) destabilizes mRNA Downregulation of SMAD2/3:SMAD4 transcriptional activity APC/C:Cdc20 mediated degradation of Securin SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription CDK-mediated phosphorylation and removal of Cdc6 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer IRAK1 recruits IKK complex Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants RNF mutants show enhanced WNT signaling and proliferation Myoclonic epilepsy of Lafora Signaling by NOTCH1 in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer IRAK2 mediated activation of TAK1 complex Loss of Function of SMAD4 in Cancer AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins Glycogen synthesis NRIF signals cell death from the nucleus Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Signaling by NOTCH1 PEST Domain Mutants in Cancer SCF(Skp2)-mediated degradation of p27/p21 Cyclin A:Cdk2-associated events at S phase entry Constitutive Signaling by NOTCH1 PEST Domain Mutants Mitotic Metaphase and Anaphase Downstream TCR signaling Antigen processing: Ubiquitination & Proteasome degradation Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Toll Like Receptor 7/8 (TLR7/8) Cascade Orc1 removal from chromatin Mitotic Anaphase deactivation of the beta-catenin transactivating complex Toll Like Receptor TLR6:TLR2 Cascade MyD88 cascade initiated on plasma membrane Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Signalling by NGF Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Cytosolic sensors of pathogen-associated DNA beta-catenin independent WNT signaling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Orc1 removal from chromatin Signaling by TGF-beta Receptor Complex CDT1 association with the CDC6:ORC:origin complex Antigen processing-Cross presentation ER-Phagosome pathway SMAD4 MH2 Domain Mutants in Cancer	Retrograde neurotrophin signalling Signalling to ERKs Signalling by NGF Prolonged ERK activation events Activation of TRKA receptors NGF signalling via TRKA from the plasma membrane ARMS-mediated activation TRKA activation by NGF PI3K/AKT activation Signalling to RAS Signalling to STAT3 NGF-independant TRKA activation PLC-gamma1 signalling Signalling to p38 via RIT and RIN Frs2-mediated activation		Amitriptyline Imatinib Regorafenib
UBB and HDAC6	ubiquitin B	histone deacetylase 6	Loss of Function of TGFBR2 in Cancer NF-kB is activated and signals survival Signaling by FGFR in disease Hedgehog 'off' state Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Glucose metabolism Toll Like Receptor TLR1:TLR2 Cascade Signaling by NOTCH1 Signaling by NOTCH2 Toll Like Receptor 5 (TLR5) Cascade AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated Stabilization of p53 Removal of licensing factors from origins Switching of origins to a post-replicative state Downregulation of ERBB2:ERBB3 signaling TGFBR2 MSI Frameshift Mutants in Cancer Signaling by NOTCH Endosomal Sorting Complex Required For Transport (ESCRT) Spry regulation of FGF signaling Signaling by NOTCH SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Regulation of innate immune responses to cytosolic DNA Autodegradation of the E3 ubiquitin ligase COP1 Toll Like Receptor 3 (TLR3) Cascade Metabolism of carbohydrates CDK-mediated phosphorylation and removal of Cdc6 Cellular response to hypoxia Hedgehog ligand biogenesis p75NTR recruits signalling complexes Fanconi Anemia pathway Separation of Sister Chromatids HIV Infection APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Synthesis And Processing Of GAG, GAGPOL Polyproteins Activated TLR4 signalling S37 mutants of beta-catenin aren't phosphorylated p53-Dependent G1 DNA Damage Response regulation of FZD by ubiquitination Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 p53-Independent DNA Damage Response MyD88:Mal cascade initiated on plasma membrane Stimuli-sensing channels Membrane binding and targetting of GAG proteins p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Downregulation of ERBB4 signaling Vpu mediated degradation of CD4 Cell death signalling via NRAGE, NRIF and NADE ISG15 antiviral mechanism Interferon Signaling M/G1 Transition p75 NTR receptor-mediated signalling Signaling by FGFR Toll Like Receptor 10 (TLR10) Cascade Signaling by NOTCH1 in Cancer TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Downregulation of TGF-beta receptor signaling truncated APC mutants destabilize the destruction complex Cyclin E associated events during G1/S transition TGF-beta receptor signaling activates SMADs Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Regulation of the Fanconi anemia pathway Generic Transcription Pathway G1/S Transition Toll Like Receptor 9 (TLR9) Cascade FBXW7 Mutants and NOTCH1 in Cancer IRAK1 recruits IKK complex Negative regulation of FGFR signaling truncations of AMER1 destabilize the destruction complex EGFR downregulation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) IRAK2 mediated activation of TAK1 complex Processing-defective Hh variants abrogate ligand secretion Regulation of activated PAK-2p34 by proteasome mediated degradation Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Signaling by ERBB4 Antiviral mechanism by IFN-stimulated genes Fc epsilon receptor (FCERI) signaling Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Interleukin-3, 5 and GM-CSF signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex M Phase APC truncation mutants are not K63 polyubiquitinated Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon HIV Life Cycle Budding and maturation of HIV virion Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation IKK complex recruitment mediated by RIP1 MAP kinase activation in TLR cascade Regulation of DNA replication Cytokine Signaling in Immune system Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell Cycle, Mitotic Signaling by TGF-beta Receptor Complex in Cancer Oxidative Stress Induced Senescence Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation TRAF6 mediated induction of TAK1 complex Negative regulators of RIG-I/MDA5 signaling misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease SMAD2/3 MH2 Domain Mutants in Cancer T41 mutants of beta-catenin aren't phosphorylated Cellular Senescence Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by EGFRvIII in Cancer Assembly Of The HIV Virion Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex NOD1/2 Signaling Pathway Glycogen storage diseases MyD88 dependent cascade initiated on endosome Mitotic G1-G1/S phases activated TAK1 mediates p38 MAPK activation Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling DNA Replication Pre-Initiation Senescence-Associated Secretory Phenotype (SASP) APC/C:Cdc20 mediated degradation of mitotic proteins TGFBR1 KD Mutants in Cancer S45 mutants of beta-catenin aren't phosphorylated Regulation of APC/C activators between G1/S and early anaphase Late Phase of HIV Life Cycle APC/C:Cdc20 mediated degradation of Cyclin B NOTCH2 Activation and Transmission of Signal to the Nucleus TCR signaling AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Interleukin-1 signaling APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Mitotic G2-G2/M phases Adaptive Immune System APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Ubiquitin-dependent degradation of Cyclin D G2/M Transition TGFBR1 LBD Mutants in Cancer Oncogene Induced Senescence Autodegradation of Cdh1 by Cdh1:APC/C Ion channel transport p75NTR signals via NF-kB Regulation of signaling by CBL XAV939 inhibits tankyrase, stabilizing AXIN Disease TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Signal Transduction Innate Immune System Synthesis of DNA Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Signaling by Ligand-Responsive EGFR Variants in Cancer Loss of Function of TGFBR1 in Cancer Ubiquitin-dependent degradation of Cyclin D1 Activated NOTCH1 Transmits Signal to the Nucleus NOTCH1 Intracellular Domain Regulates Transcription Toll-Like Receptors Cascades Cyclin D associated events in G1 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Regulation of mitotic cell cycle Signaling by Hedgehog Association of licensing factors with the pre-replicative complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Ubiquitin Mediated Degradation of Phosphorylated Cdc25A TCF7L2 mutants don't bind CTBP p53-Dependent G1/S DNA damage checkpoint Signaling by Wnt AUF1 (hnRNP D0) destabilizes mRNA Downregulation of SMAD2/3:SMAD4 transcriptional activity APC/C:Cdc20 mediated degradation of Securin SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription CDK-mediated phosphorylation and removal of Cdc6 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer IRAK1 recruits IKK complex Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants RNF mutants show enhanced WNT signaling and proliferation Myoclonic epilepsy of Lafora Signaling by NOTCH1 in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer IRAK2 mediated activation of TAK1 complex Loss of Function of SMAD4 in Cancer AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins Glycogen synthesis NRIF signals cell death from the nucleus Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Signaling by NOTCH1 PEST Domain Mutants in Cancer SCF(Skp2)-mediated degradation of p27/p21 Cyclin A:Cdk2-associated events at S phase entry Constitutive Signaling by NOTCH1 PEST Domain Mutants Mitotic Metaphase and Anaphase Downstream TCR signaling Antigen processing: Ubiquitination & Proteasome degradation Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Toll Like Receptor 7/8 (TLR7/8) Cascade Orc1 removal from chromatin Mitotic Anaphase deactivation of the beta-catenin transactivating complex Toll Like Receptor TLR6:TLR2 Cascade MyD88 cascade initiated on plasma membrane Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Signalling by NGF Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Cytosolic sensors of pathogen-associated DNA beta-catenin independent WNT signaling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Orc1 removal from chromatin Signaling by TGF-beta Receptor Complex CDT1 association with the CDC6:ORC:origin complex Antigen processing-Cross presentation ER-Phagosome pathway SMAD4 MH2 Domain Mutants in Cancer	HSF1 activation Signaling by NOTCH1 HD Domain Mutants in Cancer Organelle biogenesis and maintenance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Assembly of the primary cilium Cellular response to heat stress Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
UBB and BRCA1	ubiquitin B	breast cancer 1, early onset	Loss of Function of TGFBR2 in Cancer NF-kB is activated and signals survival Signaling by FGFR in disease Hedgehog 'off' state Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Glucose metabolism Toll Like Receptor TLR1:TLR2 Cascade Signaling by NOTCH1 Signaling by NOTCH2 Toll Like Receptor 5 (TLR5) Cascade AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated Stabilization of p53 Removal of licensing factors from origins Switching of origins to a post-replicative state Downregulation of ERBB2:ERBB3 signaling TGFBR2 MSI Frameshift Mutants in Cancer Signaling by NOTCH Endosomal Sorting Complex Required For Transport (ESCRT) Spry regulation of FGF signaling Signaling by NOTCH SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Regulation of innate immune responses to cytosolic DNA Autodegradation of the E3 ubiquitin ligase COP1 Toll Like Receptor 3 (TLR3) Cascade Metabolism of carbohydrates CDK-mediated phosphorylation and removal of Cdc6 Cellular response to hypoxia Hedgehog ligand biogenesis p75NTR recruits signalling complexes Fanconi Anemia pathway Separation of Sister Chromatids HIV Infection APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Synthesis And Processing Of GAG, GAGPOL Polyproteins Activated TLR4 signalling S37 mutants of beta-catenin aren't phosphorylated p53-Dependent G1 DNA Damage Response regulation of FZD by ubiquitination Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 p53-Independent DNA Damage Response MyD88:Mal cascade initiated on plasma membrane Stimuli-sensing channels Membrane binding and targetting of GAG proteins p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Downregulation of ERBB4 signaling Vpu mediated degradation of CD4 Cell death signalling via NRAGE, NRIF and NADE ISG15 antiviral mechanism Interferon Signaling M/G1 Transition p75 NTR receptor-mediated signalling Signaling by FGFR Toll Like Receptor 10 (TLR10) Cascade Signaling by NOTCH1 in Cancer TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Downregulation of TGF-beta receptor signaling truncated APC mutants destabilize the destruction complex Cyclin E associated events during G1/S transition TGF-beta receptor signaling activates SMADs Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Regulation of the Fanconi anemia pathway Generic Transcription Pathway G1/S Transition Toll Like Receptor 9 (TLR9) Cascade FBXW7 Mutants and NOTCH1 in Cancer IRAK1 recruits IKK complex Negative regulation of FGFR signaling truncations of AMER1 destabilize the destruction complex EGFR downregulation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) IRAK2 mediated activation of TAK1 complex Processing-defective Hh variants abrogate ligand secretion Regulation of activated PAK-2p34 by proteasome mediated degradation Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Signaling by ERBB4 Antiviral mechanism by IFN-stimulated genes Fc epsilon receptor (FCERI) signaling Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Interleukin-3, 5 and GM-CSF signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex M Phase APC truncation mutants are not K63 polyubiquitinated Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon HIV Life Cycle Budding and maturation of HIV virion Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation IKK complex recruitment mediated by RIP1 MAP kinase activation in TLR cascade Regulation of DNA replication Cytokine Signaling in Immune system Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell Cycle, Mitotic Signaling by TGF-beta Receptor Complex in Cancer Oxidative Stress Induced Senescence Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation TRAF6 mediated induction of TAK1 complex Negative regulators of RIG-I/MDA5 signaling misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease SMAD2/3 MH2 Domain Mutants in Cancer T41 mutants of beta-catenin aren't phosphorylated Cellular Senescence Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by EGFRvIII in Cancer Assembly Of The HIV Virion Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex NOD1/2 Signaling Pathway Glycogen storage diseases MyD88 dependent cascade initiated on endosome Mitotic G1-G1/S phases activated TAK1 mediates p38 MAPK activation Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling DNA Replication Pre-Initiation Senescence-Associated Secretory Phenotype (SASP) APC/C:Cdc20 mediated degradation of mitotic proteins TGFBR1 KD Mutants in Cancer S45 mutants of beta-catenin aren't phosphorylated Regulation of APC/C activators between G1/S and early anaphase Late Phase of HIV Life Cycle APC/C:Cdc20 mediated degradation of Cyclin B NOTCH2 Activation and Transmission of Signal to the Nucleus TCR signaling AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Interleukin-1 signaling APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Mitotic G2-G2/M phases Adaptive Immune System APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Ubiquitin-dependent degradation of Cyclin D G2/M Transition TGFBR1 LBD Mutants in Cancer Oncogene Induced Senescence Autodegradation of Cdh1 by Cdh1:APC/C Ion channel transport p75NTR signals via NF-kB Regulation of signaling by CBL XAV939 inhibits tankyrase, stabilizing AXIN Disease TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Signal Transduction Innate Immune System Synthesis of DNA Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Signaling by Ligand-Responsive EGFR Variants in Cancer Loss of Function of TGFBR1 in Cancer Ubiquitin-dependent degradation of Cyclin D1 Activated NOTCH1 Transmits Signal to the Nucleus NOTCH1 Intracellular Domain Regulates Transcription Toll-Like Receptors Cascades Cyclin D associated events in G1 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Regulation of mitotic cell cycle Signaling by Hedgehog Association of licensing factors with the pre-replicative complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Ubiquitin Mediated Degradation of Phosphorylated Cdc25A TCF7L2 mutants don't bind CTBP p53-Dependent G1/S DNA damage checkpoint Signaling by Wnt AUF1 (hnRNP D0) destabilizes mRNA Downregulation of SMAD2/3:SMAD4 transcriptional activity APC/C:Cdc20 mediated degradation of Securin SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription CDK-mediated phosphorylation and removal of Cdc6 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer IRAK1 recruits IKK complex Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants RNF mutants show enhanced WNT signaling and proliferation Myoclonic epilepsy of Lafora Signaling by NOTCH1 in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer IRAK2 mediated activation of TAK1 complex Loss of Function of SMAD4 in Cancer AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins Glycogen synthesis NRIF signals cell death from the nucleus Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Signaling by NOTCH1 PEST Domain Mutants in Cancer SCF(Skp2)-mediated degradation of p27/p21 Cyclin A:Cdk2-associated events at S phase entry Constitutive Signaling by NOTCH1 PEST Domain Mutants Mitotic Metaphase and Anaphase Downstream TCR signaling Antigen processing: Ubiquitination & Proteasome degradation Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Toll Like Receptor 7/8 (TLR7/8) Cascade Orc1 removal from chromatin Mitotic Anaphase deactivation of the beta-catenin transactivating complex Toll Like Receptor TLR6:TLR2 Cascade MyD88 cascade initiated on plasma membrane Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Signalling by NGF Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Cytosolic sensors of pathogen-associated DNA beta-catenin independent WNT signaling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Orc1 removal from chromatin Signaling by TGF-beta Receptor Complex CDT1 association with the CDC6:ORC:origin complex Antigen processing-Cross presentation ER-Phagosome pathway SMAD4 MH2 Domain Mutants in Cancer	ATM mediated phosphorylation of repair proteins Meiotic recombination Fanconi Anemia pathway ATM mediated response to DNA double-strand break Homologous Recombination Repair Meiotic synapsis Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Double-Strand Break Repair
UBB and HGS	ubiquitin B	hepatocyte growth factor-regulated tyrosine kinase substrate	Loss of Function of TGFBR2 in Cancer NF-kB is activated and signals survival Signaling by FGFR in disease Hedgehog 'off' state Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Glucose metabolism Toll Like Receptor TLR1:TLR2 Cascade Signaling by NOTCH1 Signaling by NOTCH2 Toll Like Receptor 5 (TLR5) Cascade AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated Stabilization of p53 Removal of licensing factors from origins Switching of origins to a post-replicative state Downregulation of ERBB2:ERBB3 signaling TGFBR2 MSI Frameshift Mutants in Cancer Signaling by NOTCH Endosomal Sorting Complex Required For Transport (ESCRT) Spry regulation of FGF signaling Signaling by NOTCH SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Regulation of innate immune responses to cytosolic DNA Autodegradation of the E3 ubiquitin ligase COP1 Toll Like Receptor 3 (TLR3) Cascade Metabolism of carbohydrates CDK-mediated phosphorylation and removal of Cdc6 Cellular response to hypoxia Hedgehog ligand biogenesis p75NTR recruits signalling complexes Fanconi Anemia pathway Separation of Sister Chromatids HIV Infection APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Synthesis And Processing Of GAG, GAGPOL Polyproteins Activated TLR4 signalling S37 mutants of beta-catenin aren't phosphorylated p53-Dependent G1 DNA Damage Response regulation of FZD by ubiquitination Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 p53-Independent DNA Damage Response MyD88:Mal cascade initiated on plasma membrane Stimuli-sensing channels Membrane binding and targetting of GAG proteins p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Downregulation of ERBB4 signaling Vpu mediated degradation of CD4 Cell death signalling via NRAGE, NRIF and NADE ISG15 antiviral mechanism Interferon Signaling M/G1 Transition p75 NTR receptor-mediated signalling Signaling by FGFR Toll Like Receptor 10 (TLR10) Cascade Signaling by NOTCH1 in Cancer TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Downregulation of TGF-beta receptor signaling truncated APC mutants destabilize the destruction complex Cyclin E associated events during G1/S transition TGF-beta receptor signaling activates SMADs Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Regulation of the Fanconi anemia pathway Generic Transcription Pathway G1/S Transition Toll Like Receptor 9 (TLR9) Cascade FBXW7 Mutants and NOTCH1 in Cancer IRAK1 recruits IKK complex Negative regulation of FGFR signaling truncations of AMER1 destabilize the destruction complex EGFR downregulation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) IRAK2 mediated activation of TAK1 complex Processing-defective Hh variants abrogate ligand secretion Regulation of activated PAK-2p34 by proteasome mediated degradation Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Signaling by ERBB4 Antiviral mechanism by IFN-stimulated genes Fc epsilon receptor (FCERI) signaling Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Interleukin-3, 5 and GM-CSF signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex M Phase APC truncation mutants are not K63 polyubiquitinated Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon HIV Life Cycle Budding and maturation of HIV virion Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation IKK complex recruitment mediated by RIP1 MAP kinase activation in TLR cascade Regulation of DNA replication Cytokine Signaling in Immune system Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell Cycle, Mitotic Signaling by TGF-beta Receptor Complex in Cancer Oxidative Stress Induced Senescence Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation TRAF6 mediated induction of TAK1 complex Negative regulators of RIG-I/MDA5 signaling misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease SMAD2/3 MH2 Domain Mutants in Cancer T41 mutants of beta-catenin aren't phosphorylated Cellular Senescence Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by EGFRvIII in Cancer Assembly Of The HIV Virion Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex NOD1/2 Signaling Pathway Glycogen storage diseases MyD88 dependent cascade initiated on endosome Mitotic G1-G1/S phases activated TAK1 mediates p38 MAPK activation Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling DNA Replication Pre-Initiation Senescence-Associated Secretory Phenotype (SASP) APC/C:Cdc20 mediated degradation of mitotic proteins TGFBR1 KD Mutants in Cancer S45 mutants of beta-catenin aren't phosphorylated Regulation of APC/C activators between G1/S and early anaphase Late Phase of HIV Life Cycle APC/C:Cdc20 mediated degradation of Cyclin B NOTCH2 Activation and Transmission of Signal to the Nucleus TCR signaling AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Interleukin-1 signaling APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Mitotic G2-G2/M phases Adaptive Immune System APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Ubiquitin-dependent degradation of Cyclin D G2/M Transition TGFBR1 LBD Mutants in Cancer Oncogene Induced Senescence Autodegradation of Cdh1 by Cdh1:APC/C Ion channel transport p75NTR signals via NF-kB Regulation of signaling by CBL XAV939 inhibits tankyrase, stabilizing AXIN Disease TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Signal Transduction Innate Immune System Synthesis of DNA Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Signaling by Ligand-Responsive EGFR Variants in Cancer Loss of Function of TGFBR1 in Cancer Ubiquitin-dependent degradation of Cyclin D1 Activated NOTCH1 Transmits Signal to the Nucleus NOTCH1 Intracellular Domain Regulates Transcription Toll-Like Receptors Cascades Cyclin D associated events in G1 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Regulation of mitotic cell cycle Signaling by Hedgehog Association of licensing factors with the pre-replicative complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Ubiquitin Mediated Degradation of Phosphorylated Cdc25A TCF7L2 mutants don't bind CTBP p53-Dependent G1/S DNA damage checkpoint Signaling by Wnt AUF1 (hnRNP D0) destabilizes mRNA Downregulation of SMAD2/3:SMAD4 transcriptional activity APC/C:Cdc20 mediated degradation of Securin SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription CDK-mediated phosphorylation and removal of Cdc6 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer IRAK1 recruits IKK complex Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants RNF mutants show enhanced WNT signaling and proliferation Myoclonic epilepsy of Lafora Signaling by NOTCH1 in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer IRAK2 mediated activation of TAK1 complex Loss of Function of SMAD4 in Cancer AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins Glycogen synthesis NRIF signals cell death from the nucleus Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Signaling by NOTCH1 PEST Domain Mutants in Cancer SCF(Skp2)-mediated degradation of p27/p21 Cyclin A:Cdk2-associated events at S phase entry Constitutive Signaling by NOTCH1 PEST Domain Mutants Mitotic Metaphase and Anaphase Downstream TCR signaling Antigen processing: Ubiquitination & Proteasome degradation Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Toll Like Receptor 7/8 (TLR7/8) Cascade Orc1 removal from chromatin Mitotic Anaphase deactivation of the beta-catenin transactivating complex Toll Like Receptor TLR6:TLR2 Cascade MyD88 cascade initiated on plasma membrane Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Signalling by NGF Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Cytosolic sensors of pathogen-associated DNA beta-catenin independent WNT signaling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Orc1 removal from chromatin Signaling by TGF-beta Receptor Complex CDT1 association with the CDC6:ORC:origin complex Antigen processing-Cross presentation ER-Phagosome pathway SMAD4 MH2 Domain Mutants in Cancer	Signaling by EGFR EGFR downregulation Endosomal Sorting Complex Required For Transport (ESCRT) Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
UBB and EPS15	ubiquitin B	epidermal growth factor receptor pathway substrate 15	Loss of Function of TGFBR2 in Cancer NF-kB is activated and signals survival Signaling by FGFR in disease Hedgehog 'off' state Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Glucose metabolism Toll Like Receptor TLR1:TLR2 Cascade Signaling by NOTCH1 Signaling by NOTCH2 Toll Like Receptor 5 (TLR5) Cascade AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated Stabilization of p53 Removal of licensing factors from origins Switching of origins to a post-replicative state Downregulation of ERBB2:ERBB3 signaling TGFBR2 MSI Frameshift Mutants in Cancer Signaling by NOTCH Endosomal Sorting Complex Required For Transport (ESCRT) Spry regulation of FGF signaling Signaling by NOTCH SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Regulation of innate immune responses to cytosolic DNA Autodegradation of the E3 ubiquitin ligase COP1 Toll Like Receptor 3 (TLR3) Cascade Metabolism of carbohydrates CDK-mediated phosphorylation and removal of Cdc6 Cellular response to hypoxia Hedgehog ligand biogenesis p75NTR recruits signalling complexes Fanconi Anemia pathway Separation of Sister Chromatids HIV Infection APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Synthesis And Processing Of GAG, GAGPOL Polyproteins Activated TLR4 signalling S37 mutants of beta-catenin aren't phosphorylated p53-Dependent G1 DNA Damage Response regulation of FZD by ubiquitination Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 p53-Independent DNA Damage Response MyD88:Mal cascade initiated on plasma membrane Stimuli-sensing channels Membrane binding and targetting of GAG proteins p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Downregulation of ERBB4 signaling Vpu mediated degradation of CD4 Cell death signalling via NRAGE, NRIF and NADE ISG15 antiviral mechanism Interferon Signaling M/G1 Transition p75 NTR receptor-mediated signalling Signaling by FGFR Toll Like Receptor 10 (TLR10) Cascade Signaling by NOTCH1 in Cancer TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Downregulation of TGF-beta receptor signaling truncated APC mutants destabilize the destruction complex Cyclin E associated events during G1/S transition TGF-beta receptor signaling activates SMADs Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Regulation of the Fanconi anemia pathway Generic Transcription Pathway G1/S Transition Toll Like Receptor 9 (TLR9) Cascade FBXW7 Mutants and NOTCH1 in Cancer IRAK1 recruits IKK complex Negative regulation of FGFR signaling truncations of AMER1 destabilize the destruction complex EGFR downregulation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) IRAK2 mediated activation of TAK1 complex Processing-defective Hh variants abrogate ligand secretion Regulation of activated PAK-2p34 by proteasome mediated degradation Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Signaling by ERBB4 Antiviral mechanism by IFN-stimulated genes Fc epsilon receptor (FCERI) signaling Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Interleukin-3, 5 and GM-CSF signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex M Phase APC truncation mutants are not K63 polyubiquitinated Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon HIV Life Cycle Budding and maturation of HIV virion Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation IKK complex recruitment mediated by RIP1 MAP kinase activation in TLR cascade Regulation of DNA replication Cytokine Signaling in Immune system Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell Cycle, Mitotic Signaling by TGF-beta Receptor Complex in Cancer Oxidative Stress Induced Senescence Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation TRAF6 mediated induction of TAK1 complex Negative regulators of RIG-I/MDA5 signaling misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease SMAD2/3 MH2 Domain Mutants in Cancer T41 mutants of beta-catenin aren't phosphorylated Cellular Senescence Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by EGFRvIII in Cancer Assembly Of The HIV Virion Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex NOD1/2 Signaling Pathway Glycogen storage diseases MyD88 dependent cascade initiated on endosome Mitotic G1-G1/S phases activated TAK1 mediates p38 MAPK activation Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling DNA Replication Pre-Initiation Senescence-Associated Secretory Phenotype (SASP) APC/C:Cdc20 mediated degradation of mitotic proteins TGFBR1 KD Mutants in Cancer S45 mutants of beta-catenin aren't phosphorylated Regulation of APC/C activators between G1/S and early anaphase Late Phase of HIV Life Cycle APC/C:Cdc20 mediated degradation of Cyclin B NOTCH2 Activation and Transmission of Signal to the Nucleus TCR signaling AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Interleukin-1 signaling APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Mitotic G2-G2/M phases Adaptive Immune System APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Ubiquitin-dependent degradation of Cyclin D G2/M Transition TGFBR1 LBD Mutants in Cancer Oncogene Induced Senescence Autodegradation of Cdh1 by Cdh1:APC/C Ion channel transport p75NTR signals via NF-kB Regulation of signaling by CBL XAV939 inhibits tankyrase, stabilizing AXIN Disease TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Signal Transduction Innate Immune System Synthesis of DNA Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Signaling by Ligand-Responsive EGFR Variants in Cancer Loss of Function of TGFBR1 in Cancer Ubiquitin-dependent degradation of Cyclin D1 Activated NOTCH1 Transmits Signal to the Nucleus NOTCH1 Intracellular Domain Regulates Transcription Toll-Like Receptors Cascades Cyclin D associated events in G1 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Regulation of mitotic cell cycle Signaling by Hedgehog Association of licensing factors with the pre-replicative complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Ubiquitin Mediated Degradation of Phosphorylated Cdc25A TCF7L2 mutants don't bind CTBP p53-Dependent G1/S DNA damage checkpoint Signaling by Wnt AUF1 (hnRNP D0) destabilizes mRNA Downregulation of SMAD2/3:SMAD4 transcriptional activity APC/C:Cdc20 mediated degradation of Securin SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription CDK-mediated phosphorylation and removal of Cdc6 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer IRAK1 recruits IKK complex Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants RNF mutants show enhanced WNT signaling and proliferation Myoclonic epilepsy of Lafora Signaling by NOTCH1 in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer IRAK2 mediated activation of TAK1 complex Loss of Function of SMAD4 in Cancer AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins Glycogen synthesis NRIF signals cell death from the nucleus Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Signaling by NOTCH1 PEST Domain Mutants in Cancer SCF(Skp2)-mediated degradation of p27/p21 Cyclin A:Cdk2-associated events at S phase entry Constitutive Signaling by NOTCH1 PEST Domain Mutants Mitotic Metaphase and Anaphase Downstream TCR signaling Antigen processing: Ubiquitination & Proteasome degradation Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Toll Like Receptor 7/8 (TLR7/8) Cascade Orc1 removal from chromatin Mitotic Anaphase deactivation of the beta-catenin transactivating complex Toll Like Receptor TLR6:TLR2 Cascade MyD88 cascade initiated on plasma membrane Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Signalling by NGF Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Cytosolic sensors of pathogen-associated DNA beta-catenin independent WNT signaling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Orc1 removal from chromatin Signaling by TGF-beta Receptor Complex CDT1 association with the CDC6:ORC:origin complex Antigen processing-Cross presentation ER-Phagosome pathway SMAD4 MH2 Domain Mutants in Cancer	Signaling by EGFR EGFR downregulation Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
CDK1 and HIST1H4A	cyclin-dependent kinase 1	histone cluster 1, H4a	Phosphorylation of the APC/C Signaling by FGFR in disease Phosphorylation of Emi1 Signaling by EGFRvIII in Cancer Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Mitotic G1-G1/S phases SHC-mediated signalling Recruitment of mitotic centrosome proteins and complexes TRIF-mediated TLR3/TLR4 signaling ERK1 activation Nuclear Pore Complex (NPC) Disassembly APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase ERK1 activation APC/C:Cdc20 mediated degradation of Cyclin B Signaling by VEGF Resolution of Sister Chromatid Cohesion Downstream signal transduction Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Interleukin-2 signaling Mitotic G2-G2/M phases Frs2-mediated activation MASTL Facilitates Mitotic Progression Axon guidance IRS-mediated signalling G2/M Transition VEGFA-VEGFR2 Pathway Activated TLR4 signalling VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling Cyclin A/B1 associated events during G2/M transition Loss of Nlp from mitotic centrosomes MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Condensation of Prometaphase Chromosomes Signaling by Insulin receptor E2F mediated regulation of DNA replication Insulin receptor signalling cascade Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes G0 and Early G1 Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Signaling by FGFR ARMS-mediated activation Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) E2F-enabled inhibition of pre-replication complex formation Regulation of mitotic cell cycle Cell Cycle Checkpoints Signaling by GPCR G2/M Checkpoints Mitotic Prophase Golgi Cisternae Pericentriolar Stack Reorganization FCERI mediated MAPK activation Regulation of PLK1 Activity at G2/M Transition SHC1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling G1/S Transition G1/S-Specific Transcription Toll Like Receptor 9 (TLR9) Cascade G2/M DNA replication checkpoint Signaling by PDGF DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 APC/C-mediated degradation of cell cycle proteins Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Condensation of Prophase Chromosomes Signaling by Leptin Signalling to ERKs Mitotic Prometaphase Prolonged ERK activation events Organelle biogenesis and maintenance ERK activation Toll Like Receptor 7/8 (TLR7/8) Cascade Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Envelope Breakdown IGF1R signaling cascade Recruitment of NuMA to mitotic centrosomes Cyclin B2 mediated events Toll Like Receptor TLR6:TLR2 Cascade M Phase IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Signalling by NGF SOS-mediated signalling G2/M DNA damage checkpoint MAP kinase activation in TLR cascade SHC-mediated signalling Depolymerisation of the Nuclear Lamina Assembly of the primary cilium Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic SHC1 events in EGFR signaling Loss of proteins required for interphase microtubule organizationÂ from the centrosome FRS2-mediated cascade IRS-mediated signalling Centrosome maturation	RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes	Indirubin-3\'-Monoxime Olomoucine Hymenialdisine SU9516 Flavopiridol Alsterpaullone
CDK1 and MYC	cyclin-dependent kinase 1	v-myc avian myelocytomatosis viral oncogene homolog	Phosphorylation of the APC/C Signaling by FGFR in disease Phosphorylation of Emi1 Signaling by EGFRvIII in Cancer Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Mitotic G1-G1/S phases SHC-mediated signalling Recruitment of mitotic centrosome proteins and complexes TRIF-mediated TLR3/TLR4 signaling ERK1 activation Nuclear Pore Complex (NPC) Disassembly APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase ERK1 activation APC/C:Cdc20 mediated degradation of Cyclin B Signaling by VEGF Resolution of Sister Chromatid Cohesion Downstream signal transduction Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Interleukin-2 signaling Mitotic G2-G2/M phases Frs2-mediated activation MASTL Facilitates Mitotic Progression Axon guidance IRS-mediated signalling G2/M Transition VEGFA-VEGFR2 Pathway Activated TLR4 signalling VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling Cyclin A/B1 associated events during G2/M transition Loss of Nlp from mitotic centrosomes MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Condensation of Prometaphase Chromosomes Signaling by Insulin receptor E2F mediated regulation of DNA replication Insulin receptor signalling cascade Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes G0 and Early G1 Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Signaling by FGFR ARMS-mediated activation Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) E2F-enabled inhibition of pre-replication complex formation Regulation of mitotic cell cycle Cell Cycle Checkpoints Signaling by GPCR G2/M Checkpoints Mitotic Prophase Golgi Cisternae Pericentriolar Stack Reorganization FCERI mediated MAPK activation Regulation of PLK1 Activity at G2/M Transition SHC1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling G1/S Transition G1/S-Specific Transcription Toll Like Receptor 9 (TLR9) Cascade G2/M DNA replication checkpoint Signaling by PDGF DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 APC/C-mediated degradation of cell cycle proteins Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Condensation of Prophase Chromosomes Signaling by Leptin Signalling to ERKs Mitotic Prometaphase Prolonged ERK activation events Organelle biogenesis and maintenance ERK activation Toll Like Receptor 7/8 (TLR7/8) Cascade Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Envelope Breakdown IGF1R signaling cascade Recruitment of NuMA to mitotic centrosomes Cyclin B2 mediated events Toll Like Receptor TLR6:TLR2 Cascade M Phase IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Signalling by NGF SOS-mediated signalling G2/M DNA damage checkpoint MAP kinase activation in TLR cascade SHC-mediated signalling Depolymerisation of the Nuclear Lamina Assembly of the primary cilium Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic SHC1 events in EGFR signaling Loss of proteins required for interphase microtubule organizationÂ from the centrosome FRS2-mediated cascade IRS-mediated signalling Centrosome maturation	Loss of Function of TGFBR2 in Cancer Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Signaling by Wnt Cyclin E associated events during G1/S transition binding of TCF/LEF:CTNNB1 to target gene promoters TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway RNF mutants show enhanced WNT signaling and proliferation G1/S Transition Signaling by NOTCH1 XAV939 inhibits tankyrase, stabilizing AXIN Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Mitotic G1-G1/S phases FBXW7 Mutants and NOTCH1 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Loss of Function of SMAD2/3 in Cancer Signaling by NOTCH formation of the beta-catenin:TCF transactivating complex TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer S Phase Cell Cycle, Mitotic Loss of Function of TGFBR1 in Cancer NOTCH1 Intracellular Domain Regulates Transcription Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex TCF dependent signaling in response to WNT Signaling by NOTCH1 PEST Domain Mutants in Cancer Cyclin A:Cdk2-associated events at S phase entry Signaling by WNT in cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants SMAD4 MH2 Domain Mutants in Cancer	Indirubin-3\'-Monoxime Olomoucine Hymenialdisine SU9516 Flavopiridol Alsterpaullone
CDK1 and HIST1H2AB	cyclin-dependent kinase 1	histone cluster 1, H2ab	Phosphorylation of the APC/C Signaling by FGFR in disease Phosphorylation of Emi1 Signaling by EGFRvIII in Cancer Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Mitotic G1-G1/S phases SHC-mediated signalling Recruitment of mitotic centrosome proteins and complexes TRIF-mediated TLR3/TLR4 signaling ERK1 activation Nuclear Pore Complex (NPC) Disassembly APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase ERK1 activation APC/C:Cdc20 mediated degradation of Cyclin B Signaling by VEGF Resolution of Sister Chromatid Cohesion Downstream signal transduction Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Interleukin-2 signaling Mitotic G2-G2/M phases Frs2-mediated activation MASTL Facilitates Mitotic Progression Axon guidance IRS-mediated signalling G2/M Transition VEGFA-VEGFR2 Pathway Activated TLR4 signalling VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling Cyclin A/B1 associated events during G2/M transition Loss of Nlp from mitotic centrosomes MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Condensation of Prometaphase Chromosomes Signaling by Insulin receptor E2F mediated regulation of DNA replication Insulin receptor signalling cascade Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes G0 and Early G1 Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Signaling by FGFR ARMS-mediated activation Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) E2F-enabled inhibition of pre-replication complex formation Regulation of mitotic cell cycle Cell Cycle Checkpoints Signaling by GPCR G2/M Checkpoints Mitotic Prophase Golgi Cisternae Pericentriolar Stack Reorganization FCERI mediated MAPK activation Regulation of PLK1 Activity at G2/M Transition SHC1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling G1/S Transition G1/S-Specific Transcription Toll Like Receptor 9 (TLR9) Cascade G2/M DNA replication checkpoint Signaling by PDGF DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 APC/C-mediated degradation of cell cycle proteins Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Condensation of Prophase Chromosomes Signaling by Leptin Signalling to ERKs Mitotic Prometaphase Prolonged ERK activation events Organelle biogenesis and maintenance ERK activation Toll Like Receptor 7/8 (TLR7/8) Cascade Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Envelope Breakdown IGF1R signaling cascade Recruitment of NuMA to mitotic centrosomes Cyclin B2 mediated events Toll Like Receptor TLR6:TLR2 Cascade M Phase IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Signalling by NGF SOS-mediated signalling G2/M DNA damage checkpoint MAP kinase activation in TLR cascade SHC-mediated signalling Depolymerisation of the Nuclear Lamina Assembly of the primary cilium Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic SHC1 events in EGFR signaling Loss of proteins required for interphase microtubule organizationÂ from the centrosome FRS2-mediated cascade IRS-mediated signalling Centrosome maturation	RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes	Indirubin-3\'-Monoxime Olomoucine Hymenialdisine SU9516 Flavopiridol Alsterpaullone
CDK1 and HIST1H2BB	cyclin-dependent kinase 1	histone cluster 1, H2bb	Phosphorylation of the APC/C Signaling by FGFR in disease Phosphorylation of Emi1 Signaling by EGFRvIII in Cancer Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Mitotic G1-G1/S phases SHC-mediated signalling Recruitment of mitotic centrosome proteins and complexes TRIF-mediated TLR3/TLR4 signaling ERK1 activation Nuclear Pore Complex (NPC) Disassembly APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase ERK1 activation APC/C:Cdc20 mediated degradation of Cyclin B Signaling by VEGF Resolution of Sister Chromatid Cohesion Downstream signal transduction Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Interleukin-2 signaling Mitotic G2-G2/M phases Frs2-mediated activation MASTL Facilitates Mitotic Progression Axon guidance IRS-mediated signalling G2/M Transition VEGFA-VEGFR2 Pathway Activated TLR4 signalling VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling Cyclin A/B1 associated events during G2/M transition Loss of Nlp from mitotic centrosomes MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Condensation of Prometaphase Chromosomes Signaling by Insulin receptor E2F mediated regulation of DNA replication Insulin receptor signalling cascade Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes G0 and Early G1 Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Signaling by FGFR ARMS-mediated activation Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) E2F-enabled inhibition of pre-replication complex formation Regulation of mitotic cell cycle Cell Cycle Checkpoints Signaling by GPCR G2/M Checkpoints Mitotic Prophase Golgi Cisternae Pericentriolar Stack Reorganization FCERI mediated MAPK activation Regulation of PLK1 Activity at G2/M Transition SHC1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling G1/S Transition G1/S-Specific Transcription Toll Like Receptor 9 (TLR9) Cascade G2/M DNA replication checkpoint Signaling by PDGF DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 APC/C-mediated degradation of cell cycle proteins Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Condensation of Prophase Chromosomes Signaling by Leptin Signalling to ERKs Mitotic Prometaphase Prolonged ERK activation events Organelle biogenesis and maintenance ERK activation Toll Like Receptor 7/8 (TLR7/8) Cascade Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Envelope Breakdown IGF1R signaling cascade Recruitment of NuMA to mitotic centrosomes Cyclin B2 mediated events Toll Like Receptor TLR6:TLR2 Cascade M Phase IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Signalling by NGF SOS-mediated signalling G2/M DNA damage checkpoint MAP kinase activation in TLR cascade SHC-mediated signalling Depolymerisation of the Nuclear Lamina Assembly of the primary cilium Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic SHC1 events in EGFR signaling Loss of proteins required for interphase microtubule organizationÂ from the centrosome FRS2-mediated cascade IRS-mediated signalling Centrosome maturation	RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Chromatin organization HDACs deacetylate histones misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes	Indirubin-3\'-Monoxime Olomoucine Hymenialdisine SU9516 Flavopiridol Alsterpaullone
CDK1 and TFDP1	cyclin-dependent kinase 1	transcription factor Dp-1	Phosphorylation of the APC/C Signaling by FGFR in disease Phosphorylation of Emi1 Signaling by EGFRvIII in Cancer Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Mitotic G1-G1/S phases SHC-mediated signalling Recruitment of mitotic centrosome proteins and complexes TRIF-mediated TLR3/TLR4 signaling ERK1 activation Nuclear Pore Complex (NPC) Disassembly APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase ERK1 activation APC/C:Cdc20 mediated degradation of Cyclin B Signaling by VEGF Resolution of Sister Chromatid Cohesion Downstream signal transduction Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Interleukin-2 signaling Mitotic G2-G2/M phases Frs2-mediated activation MASTL Facilitates Mitotic Progression Axon guidance IRS-mediated signalling G2/M Transition VEGFA-VEGFR2 Pathway Activated TLR4 signalling VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling Cyclin A/B1 associated events during G2/M transition Loss of Nlp from mitotic centrosomes MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Condensation of Prometaphase Chromosomes Signaling by Insulin receptor E2F mediated regulation of DNA replication Insulin receptor signalling cascade Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes G0 and Early G1 Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Signaling by FGFR ARMS-mediated activation Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) E2F-enabled inhibition of pre-replication complex formation Regulation of mitotic cell cycle Cell Cycle Checkpoints Signaling by GPCR G2/M Checkpoints Mitotic Prophase Golgi Cisternae Pericentriolar Stack Reorganization FCERI mediated MAPK activation Regulation of PLK1 Activity at G2/M Transition SHC1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling G1/S Transition G1/S-Specific Transcription Toll Like Receptor 9 (TLR9) Cascade G2/M DNA replication checkpoint Signaling by PDGF DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 APC/C-mediated degradation of cell cycle proteins Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Condensation of Prophase Chromosomes Signaling by Leptin Signalling to ERKs Mitotic Prometaphase Prolonged ERK activation events Organelle biogenesis and maintenance ERK activation Toll Like Receptor 7/8 (TLR7/8) Cascade Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Envelope Breakdown IGF1R signaling cascade Recruitment of NuMA to mitotic centrosomes Cyclin B2 mediated events Toll Like Receptor TLR6:TLR2 Cascade M Phase IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Signalling by NGF SOS-mediated signalling G2/M DNA damage checkpoint MAP kinase activation in TLR cascade SHC-mediated signalling Depolymerisation of the Nuclear Lamina Assembly of the primary cilium Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic SHC1 events in EGFR signaling Loss of proteins required for interphase microtubule organizationÂ from the centrosome FRS2-mediated cascade IRS-mediated signalling Centrosome maturation	Loss of Function of TGFBR2 in Cancer Cellular Senescence SMAD2/3 MH2 Domain Mutants in Cancer Activation of BH3-only proteins Oncogene Induced Senescence TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Pre-NOTCH Transcription and Translation G1/S Transition G1/S-Specific Transcription Programmed Cell Death Pre-NOTCH Expression and Processing Mitotic G1-G1/S phases Intrinsic Pathway for Apoptosis E2F mediated regulation of DNA replication TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Signaling by NOTCH TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Loss of Function of SMAD4 in Cancer G0 and Early G1 TGFBR1 KD Mutants in Cancer Cell Cycle, Mitotic Loss of Function of TGFBR1 in Cancer Activation of NOXA and translocation to mitochondria Cyclin D associated events in G1 Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Oxidative Stress Induced Senescence Activation of PUMA and translocation to mitochondria Inhibition of replication initiation of damaged DNA by RB1/E2F1 SMAD4 MH2 Domain Mutants in Cancer	Indirubin-3\'-Monoxime Olomoucine Hymenialdisine SU9516 Flavopiridol Alsterpaullone

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