PUM3 and SLC7A9

		PUM3	SLC7A9
Description		pumilio RNA binding family member 3	solute carrier family 7 member 9
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Endoplasmic Reticulum	Plasma Membrane Membrane Apical Plasma Membrane Brush Border Membrane
	Molecular Function	DNA Binding RNA Binding MRNA Binding Protein Binding	Protein Binding Amino Acid Transmembrane Transporter Activity Neutral L-amino Acid Transmembrane Transporter Activity L-cystine Transmembrane Transporter Activity Antiporter Activity Transmembrane Transporter Activity Peptide Antigen Binding Protein Heterodimerization Activity Broad Specificity Neutral L-amino Acid:basic L-amino Acid Antiporter Activity
	Biological Process	Regulation Of Translation Regulation Of Protein ADP-ribosylation	Amino Acid Transmembrane Transport Amino Acid Transport Neutral Amino Acid Transport L-cystine Transport Transmembrane Transport Protein-containing Complex Assembly L-alpha-amino Acid Transmembrane Transport Basic Amino Acid Transmembrane Transport
Pathways			Basigin interactions Amino acid transport across the plasma membrane Defective SLC3A1 causes cystinuria (CSNU) Defective SLC7A9 causes cystinuria (CSNU)
Drugs
Diseases			Cystinuria
GWAS		Depression ( 29700475) Smoking initiation ( 33082346) Waist circumference adjusted for body mass index ( 28552196)	Chronic kidney disease ( 20383146) Creatinine levels ( 20383145 29403010 31015462) Estimated glomerular filtration rate ( 31015462 30604766) Fractional excretion of metabolites in chronic kidney disease ( 29545352) Glomerular filtration rate (creatinine) ( 26831199 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Serum metabolite levels ( 33031748) Urate levels ( 31578528) Urinary metabolite levels in chronic kidney disease ( 29545352 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Urinary metabolite ratios in chronic kidney disease ( 29545352) Urinary metabolites ( 21572414) Urinary metabolites (H-NMR features) ( 24586186)
Interacting Genes		5 interacting genes: APP CALM1 CEBPA HPS6 ITGB1BP2	3 interacting genes: CREB3 HSPB1 TGM2
Entrez ID		9933	11136
HPRD ID		08822	04997
Ensembl ID		ENSG00000080608	ENSG00000021488
Uniprot IDs		Q15397	P82251
PDB IDs		4WZR 4WZW	6LI9 6LID 6YUP 6YV1
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Dendritic Shaft Growth Cone Lamellipodium Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Calcium Ion Transmembrane Transport Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Response To Metal Ion Chemical Homeostasis Intermediate-density Lipoprotein Particle Regulation Of Monoatomic Ion Transport Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Intracellular Signaling Cassette Regulation Of Membrane Potential Trans-Golgi Network Membrane Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Early Endosome Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Response To Peptide Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Synaptic Transmission Response To Cytokine Regulation Of Inflammatory Response Regulation Of Calcium-mediated Signaling Regulation Of Calcium Ion Transport Regulation Of Metal Ion Transport Protein Heterodimerization Activity Lipoprotein Particle Memory Growth Factor Receptor Binding Main Axon Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Regulation Of Monoatomic Cation Transmembrane Transport	Response To Unfolded Protein Negative Regulation Of Protein Kinase C Signaling Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Regulation Of Catalytic Activity Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity Positive Regulation Of Deacetylase Activity Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Chemotaxis Protein Deamination Positive Regulation Of Vasculature Development Positive Regulation Of Angiogenesis Protein Kinase C Inhibitor Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Serotonin Regulation Of Chemotaxis Regulation Of Protein Kinase C Signaling Negative Regulation Of Apoptotic Signaling Pathway Salivary Gland Cavitation Release From Viral Latency Dopamine Secretion Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Protein ADP-ribosylation CCR1 Chemokine Receptor Binding Cellular Response To Dopamine Positive Regulation Of Mitochondrial Calcium Ion Concentration Protein-glutamine Gamma-glutamyltransferase Activity Regulation Of Vasculature Development Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Angiogenesis Anterograde Axonal Protein Transport Positive Regulation Of Catalytic Activity Regulation Of Apoptotic Cell Clearance Cellular Response To Cocaine Response To Dopamine Catecholamine Secretion CAMP Response Element Binding Protein Binding Endoplasmic Reticulum Branching Involved In Salivary Gland Morphogenesis Regulation Of Apoptotic Signaling Pathway Protein Transport Along Microtubule Contractile Muscle Fiber Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Translation Focal Adhesion
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