RHOBTB1 and ARID5B

		RHOBTB1	ARID5B
Description		Rho related BTB domain containing 1	AT-rich interaction domain 5B
Image		No pdb structure
GO Annotations	Cellular Component	Cytoskeleton Plasma Membrane Endosome Membrane Cytoplasmic Vesicle Cell Projection	Nucleus Nucleoplasm
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Protein Kinase Binding	Transcription Cis-regulatory Region Binding DNA Binding Transcription Coactivator Activity Protein Binding
	Biological Process	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Shape Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Liver Development Regulation Of Transcription By RNA Polymerase II Male Gonad Development Female Gonad Development Post-embryonic Development Fibroblast Migration Adrenal Gland Development Multicellular Organism Growth Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Platelet-derived Growth Factor Receptor Signaling Pathway Cell Development Muscle Organ Morphogenesis Skeletal System Morphogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Roof Of Mouth Development Face Morphogenesis Adipose Tissue Development Fat Pad Development Cellular Response To Leukemia Inhibitory Factor
Pathways		RHOBTB1 GTPase cycle	HDMs demethylate histones
Drugs
Diseases
GWAS		Diastolic blood pressure ( 19430483) Femur bone mineral density x serum urate levels interaction ( 34046847) Food allergy ( 25710614) Lean body mass ( 28552196) Metabolite levels ( 23823483) Milk allergy ( 25710614) Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)	Acute lymphoblastic leukemia (B-cell precursor) ( 23996088) Acute lymphoblastic leukemia (childhood) ( 19684603 19684604 22076464 29348612 33891562 28817678 25310577 23512250) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299) Appendicular lean mass ( 33097823) Autoimmune thyroid disease ( 32581359) Automobile speeding propensity ( 30643258) B-cell acute lymphoblastic leukaemia ( 31767839) Blood urea nitrogen levels ( 31152163) Central corneal thickness ( 32528159 31798171 30894546 29760442) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Corneal resistance factor ( 30894546) Corneal structure ( 23291589) Diastolic blood pressure ( 19430483) Estimated glomerular filtration rate ( 31152163) Femur bone mineral density x serum urate levels interaction ( 34046847) Gout ( 32238385) Heel bone mineral density ( 30598549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Intraocular pressure ( 29235454 29617998) Intraocular pressure (Goldman correlated) ( 30894546) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Medication use (thyroid preparations) ( 31015401) Neutrophil percentage of white cells ( 32888494) Plateletcrit ( 27863252 32888494) Reaction time ( 29844566) Response to haloperidol in psychosis ( 24751813) Rheumatoid arthritis ( 22446963 23143596 24390342 30423114 32723749) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Serum metabolite levels ( 33031748) Serum total protein levels ( 23022100) Smoking initiation ( 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Systemic lupus erythematosus ( 26502338 27399966 33272962 23273568) Tinnitus ( 33742053) Triglyceride levels ( 32154731 32203549) Type 2 diabetes ( 32499647) Vitiligo ( 27723757) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		1 interacting genes: CUL5	1 interacting genes: RUNX1
Entrez ID		9886	84159
HPRD ID		06299	18880
Ensembl ID		ENSG00000072422	ENSG00000150347
Uniprot IDs		O94844	Q14865
PDB IDs			1IG6 2OEH
Enriched GO Terms of Interacting Partners?		Symbiont-mediated Suppression Of Host Innate Immune Response Negative Regulation Of Focal Adhesion Disassembly Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Growth Hormone Receptor Signaling Pathway Ubiquitin Ligase Complex Scaffold Activity Erythropoietin-mediated Signaling Pathway Negative Regulation Of Growth Hormone Receptor Signaling Pathway Reelin-mediated Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Muscle Organ Morphogenesis Fat Pad Development Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cul5-RING Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Negative Regulation Of CGAS/STING Signaling Pathway Layer Formation In Cerebral Cortex Negative Regulation Of Focal Adhesion Assembly Fibroblast Migration Cell Migration ERBB2 Signaling Pathway Growth Hormone Receptor Signaling Pathway Adrenal Gland Development Female Gonad Development CGAS/STING Signaling Pathway Positive Regulation Of Focal Adhesion Assembly Cell Motility Face Morphogenesis Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein K11-linked Ubiquitination Site Of DNA Damage Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Neuron Migration Adipose Tissue Development SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell-matrix Adhesion SCF Ubiquitin Ligase Complex Negative Regulation Of Cell-substrate Adhesion Endoplasmic Reticulum Unfolded Protein Response Regulation Of Focal Adhesion Assembly Connective Tissue Development Regulation Of Cell-substrate Junction Organization ERBB Signaling Pathway Post-embryonic Development Roof Of Mouth Development Calcium Channel Activity Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway
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