TOMM70 and TMEM45A

		TOMM70	TMEM45A
Description		translocase of outer mitochondrial membrane 70	transmembrane protein 45A
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Outer Membrane Translocase Complex Membrane Mitochondrial Membrane Extracellular Exosome TOM Complex	Membrane
	Molecular Function	Protein Binding Protein Transmembrane Transporter Activity Mitochondrion Targeting Sequence Binding Molecular Adaptor Activity	Protein Binding
	Biological Process	Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Protein Targeting To Mitochondrion MRNA Transcription Protein Import Into Mitochondrial Matrix Positive Regulation Of Interferon-beta Production Regulation Of Apoptotic Process Protein Insertion Into Mitochondrial Inner Membrane Protein Insertion Into Mitochondrial Outer Membrane Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Response To Thyroxine Cellular Response To Virus Antiviral Innate Immune Response Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Mitochondrial protein import DDX58/IFIH1-mediated induction of interferon-alpha/beta PINK1-PRKN Mediated Mitophagy Ub-specific processing proteases SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses
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Diseases
GWAS			Fasting glucose ( 34059833) Refractive error ( 32231278) Skin aging (microtopography measurement) ( 28502801)
Interacting Genes		9 interacting genes: HSP90AA1 HSPA1A HSPA1B HSPB1 IRF3 OGT PINK1 PRKN SNAPIN	9 interacting genes: APOA2 ARLN ERMP1 GJA8 IGFBP5 PLN SSMEM1 TMEM19 TRARG1
Entrez ID		9868	55076
HPRD ID		16194	07647
Ensembl ID		ENSG00000154174	ENSG00000181458
Uniprot IDs		O94826	J3KQ06 Q9NWC5
PDB IDs		7DHG 7KDT	7OQZ
Enriched GO Terms of Interacting Partners?		C3HC4-type RING Finger Domain Binding Protein Refolding Regulation Of Protein Ubiquitination Lysosomal Transport Regulation Of Post-translational Protein Modification Protein Folding Chaperone Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Vacuolar Transport Positive Regulation Of Gene Expression Positive Regulation Of Protein Polymerization Regulation Of Proteasomal Protein Catabolic Process Intracellular Transport Response To Unfolded Protein Response To Heat Regulation Of Protein Catabolic Process Regulation Of Protein Modification Process Mitochondrion To Lysosome Vesicle-mediated Transport Cellular Response To Hydrogen Sulfide Negative Regulation Of Apoptotic Signaling Pathway Protein Stabilization Negative Regulation Of Cellular Component Organization Aggresome Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Unfolded Protein Binding Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Hydrogen Sulfide ATP-dependent Protein Folding Chaperone Mitochondrial Transport Regulation Of Programmed Cell Death Histone Deacetylase Binding Negative Regulation Of Mitochondrial Fission Regulation Of Synaptic Vesicle Transport Cellular Localization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Establishment Of Localization In Cell Ubiquitin Protein Ligase Binding ATP-dependent Protein Disaggregase Activity Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Heat Acclimation Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Lewy Body Response To Temperature Stimulus Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Heat Cytosol Positive Regulation Of Microtubule Nucleation Mitophagy Regulation Of Ubiquitin-dependent Protein Catabolic Process	Regulation Of System Process Negative Regulation Of Muscle Hypertrophy Response To Peptide Hormone Regulation Of Muscle System Process Negative Regulation Of Skeletal Muscle Hypertrophy Response To Hormone Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of The Force Of Heart Contraction By Cardiac Conduction Calcium Ion-transporting ATPase Complex Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Peptidyl-methionine Modification High-density Lipoprotein Particle Receptor Binding Negative Regulation Of Cholesterol Import Insulin-like Growth Factor Binding Protein Complex Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Receptor Ligand Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity Regulation Of Intestinal Cholesterol Absorption Protein Oxidation Diacylglycerol Catabolic Process Regulation Of Cholesterol Import Lipase Inhibitor Activity Apolipoprotein Receptor Binding Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Clearance Gap Junction-mediated Intercellular Transport Mammary Gland Involution Insulin-like Growth Factor Ternary Complex Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Transporter Inhibitor Activity Regulation Of Cardiac Muscle Cell Membrane Potential Circadian Sleep/wake Cycle Process ATPase Inhibitor Activity Regulation Of Relaxation Of Cardiac Muscle Sleep Response To Insulin Response To Thyroxine TOM Complex Mitochondrion Targeting Sequence Binding Response To L-phenylalanine Derivative Glucose Import In Response To Insulin Stimulus
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