TOMM70 and CTNNA2

		TOMM70	CTNNA2
Description		translocase of outer mitochondrial membrane 70	catenin alpha 2
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Outer Membrane Translocase Complex Membrane Mitochondrial Membrane Extracellular Exosome TOM Complex	Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Postsynaptic Density Actin Cytoskeleton Membrane Basolateral Plasma Membrane Catenin Complex Lamellipodium Axon Cell Projection Anchoring Junction Hippocampal Mossy Fiber To CA3 Synapse Parallel Fiber To Purkinje Cell Synapse Presynaptic Active Zone Cytoplasmic Component Extrinsic Component Of Presynaptic Membrane Extrinsic Component Of Postsynaptic Membrane Postsynaptic Density, Intracellular Component
	Molecular Function	Protein Binding Protein Transmembrane Transporter Activity Mitochondrion Targeting Sequence Binding Molecular Adaptor Activity	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Beta-catenin Binding Identical Protein Binding Cadherin Binding Actin Filament Binding
	Biological Process	Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Protein Targeting To Mitochondrion MRNA Transcription Protein Import Into Mitochondrial Matrix Positive Regulation Of Interferon-beta Production Regulation Of Apoptotic Process Protein Insertion Into Mitochondrial Inner Membrane Protein Insertion Into Mitochondrial Outer Membrane Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Response To Thyroxine Cellular Response To Virus Antiviral Innate Immune Response Positive Regulation Of Protein Targeting To Mitochondrion	Cytoskeleton Organization Cell Adhesion Axonogenesis Regulation Of Neuron Projection Development Cell Migration Radial Glia Guided Migration Of Purkinje Cell Cell Differentiation Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Dendrite Morphogenesis Brain Morphogenesis Regulation Of Synapse Structural Plasticity Prepulse Inhibition Cell-cell Adhesion Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Neuron Migration
Pathways		Mitochondrial protein import DDX58/IFIH1-mediated induction of interferon-alpha/beta PINK1-PRKN Mediated Mitophagy Ub-specific processing proteases SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses	Myogenesis Myogenesis
Drugs
Diseases
GWAS			Adult body size ( 32376654) Alcohol consumption ( 28937693) Alcohol dependence or heroin dependence or methamphetamine dependence ( 31462767) Alzheimer's disease (cognitive decline) ( 23535033) Bipolar disorder ( 19416921) Body mass index ( 25673413 26426971) Bone mineral density (femoral neck) ( 26911590) Breast cancer ( 25824743) Cerebral microbleeds ( 31209788) Cerebrospinal fluid clusterin levels ( 26545630) Cleft palate ( 30452639) Cognitive function ( 25644384) Contrast sensitivity ( 24152035) Cooked vegetable consumption ( 32066663) Femur bone mineral density x serum urate levels interaction ( 34046847) Fish- and plant-related diet ( 32066663) Gut microbiota relative abundance (Bacteroides) ( 33208821) Heel bone mineral density x serum urate levels interaction ( 34046847) LDL cholesterol levels in HIV infection ( 33109212) Mild influenza (H1N1) infection ( 26379185) Multisite chronic pain ( 31194737 33830993) Orthostatic hypotension ( 24124408) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Protein quantitative trait loci ( 18464913) Raw vegetable consumption ( 32066663) Refractive error ( 32231278) Response to cytadine analogues (cytosine arabinoside) ( 24483146) Response to lurasidone in schizophrenia ( 29730043) Schizophrenia (MTAG) ( 32107650) Survival in pancreatic cancer ( 28470677)
Interacting Genes		9 interacting genes: HSP90AA1 HSPA1A HSPA1B HSPB1 IRF3 OGT PINK1 PRKN SNAPIN	3 interacting genes: CCDC88A CTNNBIP1 PTPN14
Entrez ID		9868	1496
HPRD ID		16194	00228
Ensembl ID		ENSG00000154174	ENSG00000066032
Uniprot IDs		O94826	F6KRI5 P26232 Q49AD3
PDB IDs		7DHG 7KDT	6DUW
Enriched GO Terms of Interacting Partners?		C3HC4-type RING Finger Domain Binding Protein Refolding Regulation Of Protein Ubiquitination Lysosomal Transport Regulation Of Post-translational Protein Modification Protein Folding Chaperone Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Vacuolar Transport Positive Regulation Of Gene Expression Positive Regulation Of Protein Polymerization Regulation Of Proteasomal Protein Catabolic Process Intracellular Transport Response To Unfolded Protein Response To Heat Regulation Of Protein Catabolic Process Regulation Of Protein Modification Process Mitochondrion To Lysosome Vesicle-mediated Transport Cellular Response To Hydrogen Sulfide Negative Regulation Of Apoptotic Signaling Pathway Protein Stabilization Negative Regulation Of Cellular Component Organization Aggresome Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Unfolded Protein Binding Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Hydrogen Sulfide ATP-dependent Protein Folding Chaperone Mitochondrial Transport Regulation Of Programmed Cell Death Histone Deacetylase Binding Negative Regulation Of Mitochondrial Fission Regulation Of Synaptic Vesicle Transport Cellular Localization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Establishment Of Localization In Cell Ubiquitin Protein Ligase Binding ATP-dependent Protein Disaggregase Activity Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Heat Acclimation Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Lewy Body Response To Temperature Stimulus Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Heat Cytosol Positive Regulation Of Microtubule Nucleation Mitophagy Regulation Of Ubiquitin-dependent Protein Catabolic Process	Regulation Of Protein Localization Maintenance Of Protein Location In Plasma Membrane Regulation Of Vascular Permeability Involved In Acute Inflammatory Response Beta-catenin-ICAT Complex
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