TOMM70 and KIF2C

		TOMM70	KIF2C
Description		translocase of outer mitochondrial membrane 70	kinesin family member 2C
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Outer Membrane Translocase Complex Membrane Mitochondrial Membrane Extracellular Exosome TOM Complex	Chromosome, Centromeric Region Kinetochore Nucleus Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Kinesin Complex Microtubule Cytoplasmic Microtubule Microtubule Cytoskeleton Membrane Microtubule Plus-end Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Protein Transmembrane Transporter Activity Mitochondrion Targeting Sequence Binding Molecular Adaptor Activity	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP Hydrolysis Activity Centromeric DNA Binding Microtubule Plus-end Binding
	Biological Process	Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Protein Targeting To Mitochondrion MRNA Transcription Protein Import Into Mitochondrial Matrix Positive Regulation Of Interferon-beta Production Regulation Of Apoptotic Process Protein Insertion Into Mitochondrial Inner Membrane Protein Insertion Into Mitochondrial Outer Membrane Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Response To Thyroxine Cellular Response To Virus Antiviral Innate Immune Response Positive Regulation Of Protein Targeting To Mitochondrion	Mitotic Sister Chromatid Segregation Microtubule-based Movement Microtubule Depolymerization Chromosome Segregation Mitotic Metaphase Chromosome Alignment Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Cell Division Metaphase Chromosome Alignment Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Chromosome Segregation Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Postsynaptic Cytoskeleton Organization
Pathways		Mitochondrial protein import DDX58/IFIH1-mediated induction of interferon-alpha/beta PINK1-PRKN Mediated Mitophagy Ub-specific processing proteases SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins COPI-dependent Golgi-to-ER retrograde traffic Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Kinesins
Drugs			Phosphoaminophosphonic Acid-Adenylate Ester
Diseases
GWAS
Interacting Genes		9 interacting genes: HSP90AA1 HSPA1A HSPA1B HSPB1 IRF3 OGT PINK1 PRKN SNAPIN	11 interacting genes: APP AURKA CEBPA CENPH CSNK2B H3-4 NDEL1 PLK1 SUMO2 VHL ZNF566
Entrez ID		9868	11004
HPRD ID		16194	05172
Ensembl ID		ENSG00000154174	ENSG00000142945
Uniprot IDs		O94826	A0A140VKF1 B7Z6Q6 B7Z7M6 Q99661
PDB IDs		7DHG 7KDT	2HEH 4UBF 4Y05 5MIO
Enriched GO Terms of Interacting Partners?		C3HC4-type RING Finger Domain Binding Protein Refolding Regulation Of Protein Ubiquitination Lysosomal Transport Regulation Of Post-translational Protein Modification Protein Folding Chaperone Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Vacuolar Transport Positive Regulation Of Gene Expression Positive Regulation Of Protein Polymerization Regulation Of Proteasomal Protein Catabolic Process Intracellular Transport Response To Unfolded Protein Response To Heat Regulation Of Protein Catabolic Process Regulation Of Protein Modification Process Mitochondrion To Lysosome Vesicle-mediated Transport Cellular Response To Hydrogen Sulfide Negative Regulation Of Apoptotic Signaling Pathway Protein Stabilization Negative Regulation Of Cellular Component Organization Aggresome Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Unfolded Protein Binding Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Hydrogen Sulfide ATP-dependent Protein Folding Chaperone Mitochondrial Transport Regulation Of Programmed Cell Death Histone Deacetylase Binding Negative Regulation Of Mitochondrial Fission Regulation Of Synaptic Vesicle Transport Cellular Localization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Establishment Of Localization In Cell Ubiquitin Protein Ligase Binding ATP-dependent Protein Disaggregase Activity Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Heat Acclimation Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Lewy Body Response To Temperature Stimulus Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Heat Cytosol Positive Regulation Of Microtubule Nucleation Mitophagy Regulation Of Ubiquitin-dependent Protein Catabolic Process	Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Centrosome Separation Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Kinetochore Mitotic Centrosome Separation Axon Hillock Mitotic Spindle Organization Positive Regulation Of Catabolic Process Regulation Of Neurotransmitter Uptake Developmental Cell Growth Protein Heterodimerization Activity Protein Serine/threonine Kinase Binding Molecular Function Activator Activity Developmental Growth Involved In Morphogenesis Chromosome Segregation Protein Localization To Centrosome Spindle Midzone Amyloid Fibril Formation Spindle Organization Chromosome, Centromeric Region Centrosome Localization Microtubule-based Process Establishment Of Mitotic Spindle Orientation Positive Regulation Of Protein Metabolic Process Mitotic Spindle Pole Microtubule Cytoskeleton Organization Establishment Of Mitotic Spindle Localization Spindle Microtubule Peptidyl-serine Phosphorylation Establishment Of Spindle Orientation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Localization RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Protein Localization To Cytoskeleton Centrosome Cycle Histone H3K36me2/H3K36me3 Demethylase Activity
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