PSMD6 and ZFAND5

Number of citations of the paper that reports this interaction (PubMedID 16424905)
60

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, two hybrid)

		PSMD6	ZFAND5
Description		proteasome 26S subunit, non-ATPase 6	zinc finger AN1-type containing 5
Image
GO Annotations	Cellular Component	Proteasome Complex Extracellular Region Nucleoplasm Cytosol Proteasome Regulatory Particle Proteasome Accessory Complex Protein-containing Complex Secretory Granule Lumen Ficolin-1-rich Granule Lumen	Cytoplasm
	Molecular Function	Protein Binding	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	In Utero Embryonic Development Vasculature Development Respiratory System Process Fibroblast Migration Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis Smooth Muscle Tissue Development Face Development
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Neutrophil degranulation Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Diisocyanate-induced asthma ( 25918132) Estimated glomerular filtration rate ( 31152163) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736) Schizophrenia ( 25056061 29483656) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 22158537 26818947 30297969 30718926 32499647)	Sensorimotor dexterity ( 31596458)
Interacting Genes		10 interacting genes: CEBPA CMTM7 FAM107A GORASP2 PSMD7 SEM1 SLC25A21-AS1 TRAF6 UBC ZFAND5	14 interacting genes: APP CCNB1 IKBKG LRRK2 MAP3K1 MFHAS1 PSMD6 PTTG1 RAD23B RIPK1 SMURF1 TNFAIP3 TRAF6 UBC
Entrez ID		9861	7763
HPRD ID		18370	05302
Ensembl ID		ENSG00000163636	ENSG00000107372
Uniprot IDs		Q15008	O76080
PDB IDs		5GJQ 5GJR 5L4K 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHS 6MSB 6MSD 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8CVT 8JRI 8JRT 8JTI 8K0G 8USB 8USC 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q	7QXW
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Protein Metabolic Process Positive Regulation Of JNK Cascade Positive Regulation Of Defense Response Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Cytosol Positive Regulation Of Immune System Process Regulation Of JNK Cascade Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Immune System Process Protein Metabolic Process Regulation Of Tumor Necrosis Factor Production Regulation Of Proteolysis Regulation Of Apoptotic Signaling Pathway Cellular Response To Stress Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Inflammatory Response Canonical NF-kappaB Signal Transduction Positive Regulation Of Proteolysis Positive Regulation Of MAPK Cascade Response To Stress Cellular Response To Manganese Ion JUN Kinase Kinase Kinase Activity Intracellular Signal Transduction Regulation Of Defense Response Intracellular Signaling Cassette Negative Regulation Of Apoptotic Signaling Pathway Signaling Adaptor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Oxygen-containing Compound Positive Regulation Of Catabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Intracellular Signal Transduction Response To Manganese Ion Regulation Of Immune Response Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Golgi-associated Vesicle Cytoplasm Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Tumor Necrosis Factor Production Cellular Response To Reactive Oxygen Species Cellular Response To Catecholamine Stimulus Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Canonical NF-kappaB Signal Transduction
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