SCRN1 and NPC2

		SCRN1	NPC2
Description		secernin 1	NPC intracellular cholesterol transporter 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Nuclear Membrane Presynapse	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	Protein Binding Dipeptidase Activity Cysteine-type Exopeptidase Activity	Protein Binding Cholesterol Binding Enzyme Binding Sterol Binding Cholesterol Transfer Activity
	Biological Process	Proteolysis Exocytosis Regulation Of Synaptic Vesicle Cycle	Lipid Metabolic Process Lipid Transport Steroid Metabolic Process Cholesterol Metabolic Process Response To Virus Gene Expression Cholesterol Storage Phospholipid Transport Sterol Transport Sterol Metabolic Process Regulation Of Isoprenoid Metabolic Process Cholesterol Transport Intracellular Sterol Transport Intracellular Cholesterol Transport Cholesterol Efflux Cholesterol Homeostasis Glycolipid Transport
Pathways			Neutrophil degranulation LDL clearance
Drugs
Diseases			Niemann-Pick type C disease (NPC), including: Niemann-Pick disease, type C1; Niemann-Pick disease, type C2
GWAS		Obesity-related traits ( 23251661) Psoriasis ( 25854761)	Intraocular pressure ( 31959993) Refractive error ( 32231278) Soluble receptor for advanced glycation end-product levels ( 26915486)
Interacting Genes		4 interacting genes: GORASP1 HGS OGT ZNF25	9 interacting genes: BARD1 BRCA1 DHDDS ECT2 ERRFI1 LIG4 PAXIP1 TRIM14 USP4
Entrez ID		9805	10577
HPRD ID		15304	03008
Ensembl ID		ENSG00000136193	ENSG00000119655
Uniprot IDs		A0A090N7T9 Q12765	A0A024R6C0 G3V3E8 P61916
PDB IDs			5KWY 6W5V
Enriched GO Terms of Interacting Partners?		Protein Localization To Lysosome Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Protein Localization To Vacuole Negative Regulation Of Developmental Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Glycoprotein Biosynthetic Process Positive Regulation Of Transcription By Glucose Macroautophagy Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity ESCRT-0 Complex Phagocytic Vesicle Lumen Cholesterol Storage Sterol Binding Regulation Of Isoprenoid Metabolic Process Carbon Catabolite Regulation Of Transcription Glycoprotein Metabolic Process Glycolipid Transport Autophagy Regulation Of Transcription By Glucose Negative Regulation Of Multicellular Organismal Process Golgi Ribbon Formation Negative Regulation Of Dendrite Morphogenesis NSL Complex Regulation Of Lipid Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway	Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity Response To Ionizing Radiation Cellular Response To Ionizing Radiation BRCA1-BARD1 Complex BRCA1-B Complex Nuclear Ubiquitin Ligase Complex BRCA1-C Complex BRCA1-A Complex Cellular Response To Radiation Ubiquitin-modified Histone Reader Activity Response To Radiation DNA Strand Resection Involved In Replication Fork Processing DNA Recombination Response To Stress Cellular Response To Stress Regulation Of Cell Cycle G2/M Phase Transition Regulation Of DNA Damage Checkpoint Macromolecule Metabolic Process Protein K6-linked Ubiquitination Protein Metabolic Process Ubiquitin Protein Ligase Activity Condensed Chromosome Homologous Recombination Regulation Of Protein Metabolic Process Negative Regulation Of MRNA 3'-end Processing Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Establishment Of Integrated Proviral Latency Adenosine Receptor Binding Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Polyprenol Biosynthetic Process Dehydrodolichyl Diphosphate Synthase Complex Ditrans,polycis-polyprenyl Diphosphate Synthase [(2E,6E)-farnesyl Diphosphate Specific] Activity Adipose Tissue Development Mitotic G2/M Transition Checkpoint Post-translational Protein Modification DNA Repair Establishment Of Viral Latency Protein K33-linked Ubiquitination Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate
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