MTSS1 and MZF1

Number of citations of the paper that reports this interaction (PubMedID 32929338)
57

Data Source:
BioGRID (unspecified method)

		MTSS1	MZF1
Description		MTSS I-BAR domain containing 1	myeloid zinc finger 1
Image
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytoskeleton Cytoplasmic Side Of Plasma Membrane Actin Cytoskeleton Endocytic Vesicle	Nucleus Nucleoplasm
	Molecular Function	Actin Binding Actin Monomer Binding Signaling Receptor Binding Protein Binding Phospholipid Binding Identical Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Plasma Membrane Organization Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Microspike Assembly Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Bundle Assembly Adherens Junction Maintenance Negative Regulation Of Epithelial Cell Proliferation Renal Tubule Morphogenesis Cellular Response To Fluid Shear Stress Glomerulus Morphogenesis Nephron Tubule Epithelial Cell Differentiation Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015) Cognitive function ( 24684796) Cognitive performance in schizophrenia or bipolar disorder ( 31872970) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Irritable bowel syndrome ( 29626450) Left ventricle diastolic internal dimension ( 28394258) Left ventricular ejection fraction ( 31554410 32382064 33495596) Left ventricular end-systolic volume ( 32382064 33495596) Left ventricular global circumferential strain ( 33495596)
Interacting Genes		5 interacting genes: HTT MZF1 PTPRD RBCK1 RECQL5	9 interacting genes: CBL CDK4 CDK6 FHL3 LDOC1 MTSS1 SCAND1 ZNF174 ZNF202
Entrez ID		9788	7593
HPRD ID		12243	01930
Ensembl ID		ENSG00000170873	ENSG00000099326
Uniprot IDs		A5YM41 O43312	P28698
PDB IDs		2D1K	2FI2
Enriched GO Terms of Interacting Partners?		Regulation Of CAMKK-AMPK Signaling Cascade Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Aggrephagy Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Lipophagy Positive Regulation Of CAMKK-AMPK Signaling Cascade Phosphoprotein Phosphatase Activity Identical Protein Binding Trans-synaptic Signaling By Trans-synaptic Complex Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Mitotic DNA Replication Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Nuclear DNA Replication Catalytic Activity, Acting On DNA Four-way Junction Helicase Activity Cellular Response To Camptothecin Mitotic DNA-templated DNA Replication LUBAC Complex Protein Linear Polyubiquitination Vocal Learning Regulation Of Organelle Assembly Observational Learning Presynaptic Membrane Assembly Profilin Binding Presynaptic Membrane Organization Chromosome Separation Presynapse Assembly 3'-5' DNA Helicase Activity Transcription Preinitiation Complex Ubiquitin Ligase Activator Activity Auditory Behavior Positive Regulation Of Cell Projection Organization Dynactin Binding Mechanosensory Behavior Regulation Of Postsynaptic Density Assembly Regulation Of Apoptotic Signaling Pathway Transmembrane Receptor Protein Tyrosine Phosphatase Activity	Cyclin Binding Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Epithelial Cell Proliferation Cell Cycle G1/S Phase Transition Positive Regulation Of Fibroblast Proliferation G1/S Transition Of Mitotic Cell Cycle Regulation Of Fibroblast Proliferation Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Cyclin-dependent Protein Kinase Holoenzyme Complex Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex Cyclin D2-CDK6 Complex FBXO Family Protein Binding Nephron Tubule Epithelial Cell Differentiation Regulation Of G2/M Transition Of Mitotic Cell Cycle Ruffle Cyclin D2-CDK4 Complex Glomerulus Morphogenesis Regulation Of Cell Cycle G2/M Phase Transition Ubiquitin-dependent Endocytosis Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Regulation Of Rap Protein Signal Transduction Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Response To Ionomycin Gliogenesis Negative Regulation Of Monocyte Differentiation Cell Dedifferentiation Negative Regulation Of Epithelial Cell Proliferation Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis Adherens Junction Maintenance Microspike Assembly Maternal Process Involved In Parturition Cellular Response To Lipopolysaccharide
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