MTSS1

Description		MTSS I-BAR domain containing 1
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GO Annotations	Cellular Component	Ruffle Cytoplasm Cytoskeleton Cytoplasmic Side Of Plasma Membrane Actin Cytoskeleton Endocytic Vesicle
	Molecular Function	Actin Binding Actin Monomer Binding Signaling Receptor Binding Protein Binding Phospholipid Binding Identical Protein Binding
	Biological Process	Plasma Membrane Organization Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Microspike Assembly Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Bundle Assembly Adherens Junction Maintenance Negative Regulation Of Epithelial Cell Proliferation Renal Tubule Morphogenesis Cellular Response To Fluid Shear Stress Glomerulus Morphogenesis Nephron Tubule Epithelial Cell Differentiation Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis
Pathways
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015) Cognitive function ( 24684796) Cognitive performance in schizophrenia or bipolar disorder ( 31872970) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Irritable bowel syndrome ( 29626450) Left ventricle diastolic internal dimension ( 28394258) Left ventricular ejection fraction ( 31554410 32382064 33495596) Left ventricular end-systolic volume ( 32382064 33495596) Left ventricular global circumferential strain ( 33495596)
Interacting Genes		5 interacting genes: HTT MZF1 PTPRD RBCK1 RECQL5
Entrez ID		9788
HPRD ID		12243
Ensembl ID		ENSG00000170873
Uniprot IDs		A5YM41 O43312
PDB IDs		2D1K
Enriched GO Terms of Interacting Partners?		Regulation Of CAMKK-AMPK Signaling Cascade Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Aggrephagy Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Lipophagy Positive Regulation Of CAMKK-AMPK Signaling Cascade Phosphoprotein Phosphatase Activity Identical Protein Binding Trans-synaptic Signaling By Trans-synaptic Complex Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Mitotic DNA Replication Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Nuclear DNA Replication Catalytic Activity, Acting On DNA Four-way Junction Helicase Activity Cellular Response To Camptothecin Mitotic DNA-templated DNA Replication LUBAC Complex Protein Linear Polyubiquitination Vocal Learning Regulation Of Organelle Assembly Observational Learning Presynaptic Membrane Assembly Profilin Binding Presynaptic Membrane Organization Chromosome Separation Presynapse Assembly 3'-5' DNA Helicase Activity Transcription Preinitiation Complex Ubiquitin Ligase Activator Activity Auditory Behavior Positive Regulation Of Cell Projection Organization Dynactin Binding Mechanosensory Behavior Regulation Of Postsynaptic Density Assembly Regulation Of Apoptotic Signaling Pathway Transmembrane Receptor Protein Tyrosine Phosphatase Activity
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