USP34 and WDPCP

		USP34	WDPCP
Description		ubiquitin specific peptidase 34	WD repeat containing planar cell polarity effector
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GO Annotations	Cellular Component	Nucleus Cytosol	Cytoplasm Cytoskeleton Plasma Membrane Cilium Axoneme Cell Cortex Membrane Apical Plasma Membrane Cell Projection Axonemal Basal Plate
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	Phosphatidylinositol Binding
	Biological Process	Proteolysis Regulation Of Signal Transduction Wnt Signaling Pathway Protein Deubiquitination Regulation Of Protein Stability Post-translational Protein Modification Protein K48-linked Deubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway	Establishment Of Planar Polarity Kidney Development Auditory Receptor Cell Morphogenesis Smoothened Signaling Pathway Nervous System Development Regulation Of Fibroblast Migration Regulation Of Embryonic Cell Shape Neural Tube Development Cell Projection Organization Septin Cytoskeleton Organization Regulation Of Protein Localization Intraciliary Transport Embryonic Digit Morphogenesis Camera-type Eye Development Tongue Morphogenesis Cilium Organization Establishment Of Protein Localization Embryonic Organ Development Regulation Of Focal Adhesion Assembly Digestive System Development Roof Of Mouth Development Cilium Assembly Respiratory System Development Circulatory System Development Podocyte Cell Migration Regulation Of Ruffle Assembly Regulation Of Cilium Assembly Regulation Of Establishment Of Cell Polarity
Pathways		TCF dependent signaling in response to WNT Ub-specific processing proteases
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737) Body fat mass ( 28552196) Chronotype ( 30696823) Crohn's disease ( 22412388) Diastolic blood pressure ( 30224653) Erectile dysfunction ( 30583798) Estimated glomerular filtration rate ( 31152163) Height ( 31562340) Immature fraction of reticulocytes ( 27863252 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Morning person ( 30696823) Mosquito bite size ( 28199695) Serum alkaline phosphatase levels ( 33547301) Serum uric acid levels ( 30993211 29403010) Urate levels ( 31578528)	Academic attainment (English) ( 33594131) Anxiety ( 33859377) Asthma and attention deficit hyperactivity disorder ( 31619474) Childhood ear infection ( 27182965) Cutaneous malignant melanoma ( 26237428) Depression ( 33859377) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Number of sexual partners ( 30643258) Obesity-related traits ( 23251661) Prostate cancer ( 31562322) Regular attendance at a religious group ( 29970889) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		5 interacting genes: DYRK1A FTCD MTNR1A MTNR1B UBC
Entrez ID		9736	51057
HPRD ID		11665	14228
Ensembl ID		ENSG00000115464	ENSG00000143951
Uniprot IDs		Q70CQ2	O95876
PDB IDs		7W3R 7W3U	7Q3D
Enriched GO Terms of Interacting Partners?		Melatonin Receptor Activity Histone H3T45 Kinase Activity G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Camera-type Eye Development Glutamate Formimidoyltransferase Activity Formimidoyltetrahydrofolate Cyclodeaminase Activity Axonemal Basal Plate L-histidine Catabolic Process To Glutamate And Formate L-histidine Catabolic Process To Glutamate And Formamide Regulation Of Embryonic Cell Shape Eye Development Circadian Rhythm Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Sensory Organ Development Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep L-histidine Metabolic Process L-histidine Catabolic Process Formate Metabolic Process Septin Cytoskeleton Organization Tongue Morphogenesis Auditory Receptor Cell Morphogenesis Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Podocyte Cell Migration Smooth Endoplasmic Reticulum Membrane Respiratory System Development Rhythmic Process Regulation Of Heterochromatin Formation Digestive System Development RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Folic Acid Binding Neurofilament Negative Regulation Of Vasoconstriction Regulation Of CGMP-mediated Signaling Amide Catabolic Process Negative Regulation Of Microtubule Polymerization Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Tag Activity Hormone Binding Negative Regulation Of Cytosolic Calcium Ion Concentration Plasma Membrane Regulation Of Transmission Of Nerve Impulse	Calcium-dependent Protein Serine/threonine Phosphatase Activity Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Cytosol Regulation Of Protein Stability Astral Microtubule Nuclear Polyadenylation-dependent MRNA Catabolic Process RRNA Transport RRNA Import Into Mitochondrion Positive Regulation Of Mitochondrial RNA Catabolic Process Mitochondrial Degradosome Mitochondrial MRNA Catabolic Process Polyribonucleotide Nucleotidyltransferase Activity Negative Regulation Of Hypoxia-inducible Factor-1alpha Signaling Pathway Positive Regulation Of Cholesterol Import Positive Regulation Of Endosome To Plasma Membrane Protein Transport Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Calcineurin Complex ScaRNA Localization To Cajal Body N-acetyllactosaminide Beta-1,3-N-acetylglucosaminyltransferase Activity Poly-N-acetyllactosamine Biosynthetic Process Mitochondrial MRNA Polyadenylation Mitochondrial RNA 3'-end Processing Exoribonuclease Complex RNA Import Into Mitochondrion Positive Regulation Of MiRNA Catabolic Process Mitochondrial RNA 5'-end Processing Regulation Of Cholesterol Import Regulation Of Plasma Lipoprotein Particle Levels
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