ZNF592 and AGBL1

		ZNF592	AGBL1
Description		zinc finger protein 592	AGBL carboxypeptidase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytoplasm Cytosol Microtubule Cytoskeleton
	Molecular Function	DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding PH Domain Binding Insulin Receptor Substrate Binding Metal Ion Binding	Carboxypeptidase Activity Metallocarboxypeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Tubulin Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Regulation Of DNA-templated Transcription Negative Regulation Of Insulin Receptor Signaling Pathway	Proteolysis C-terminal Protein Deglutamylation Protein Side Chain Deglutamylation
Pathways			Carboxyterminal post-translational modifications of tubulin
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Alzheimer's disease (age of onset) ( 22005931) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756 33263727 34002096) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Hypertrophic cardiomyopathy ( 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Schizophrenia ( 29483656)	Activated partial thromboplastin time ( 22703881) Acute lymphoblastic leukemia ( 33891562) Acute lymphoblastic leukemia (adult) ( 33891562) Anxiety ( 33859377) Bitter alcoholic beverage consumption ( 31046077) Coronary artery calcification ( 23870195) Cytomegalovirus antibody response ( 21993531) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Ischemic stroke ( 26089329) Logical memory (delayed recall) in normal cognition ( 29274321) Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Migraine ( 21448238) Modified Stumvoll Insulin Sensitivity Index (BMI interaction) ( 27416945) Neurociticism ( 29500382) Neuroticism ( 29255261) Psychosis (methamphetamine induced) ( 23594818) Response to anti-depressant treatment in major depressive disorder ( 22041458) Rostral middle frontal gyrus volume ( 31530798) Schizophrenia ( 18347602) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Triglyceride levels in HIV infection ( 33109212) Triiodothyronine levels ( 30843173) Venous thromboembolism ( 33592630)
Interacting Genes		6 interacting genes: BTG3 GRIK1 LAMTOR5 SMAD9 SRPK2 TCAF1
Entrez ID		9640	123624
HPRD ID		10339	07115
Ensembl ID		ENSG00000166716	ENSG00000273540
Uniprot IDs		Q92610	A0A1B0GVQ2 Q96MI9
PDB IDs
Enriched GO Terms of Interacting Partners?			PH Domain Binding Signal Peptide Processing Signal Peptidase Complex Insulin Receptor Substrate Binding
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