ABCG1 and ABCG4

Number of citations of the paper that reports this interaction (PMID 15240127)
13

Data Source:
HPRD (in vitro, in vivo)

		ABCG1	ABCG4
Gene Name		ATP-binding cassette, sub-family G (WHITE), member 1	ATP-binding cassette, sub-family G (WHITE), member 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleoplasm Mitochondrion Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Intracellular Membrane-bounded Organelle Recycling Endosome	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding ATP Binding Phospholipid Binding Phospholipid Transporter Activity Cholesterol Binding Cholesterol Transporter Activity Toxin Transporter Activity Sterol-transporting ATPase Activity Glycoprotein Transporter Activity Protein Homodimerization Activity ADP Binding Protein Heterodimerization Activity Protein Dimerization Activity	Protein Binding ATP Binding ATPase Activity Cholesterol Transporter Activity Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Regulation Of Transcription, DNA-templated Cholesterol Metabolic Process Detection Of Hormone Stimulus Response To Organic Substance Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Cholesterol Esterification Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Intracellular Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Response To Lipid Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Glycoprotein Transport Lipoprotein Metabolic Process Cholesterol Homeostasis Amyloid Precursor Protein Catabolic Process Reverse Cholesterol Transport Small Molecule Metabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Transmembrane Transport Phospholipid Homeostasis Response To High Density Lipoprotein Particle Toxin Transport	Metabolic Process Cholesterol Efflux Transmembrane Transport
Pathways		Lipoprotein metabolism HDL-mediated lipid transport ABC-family proteins mediated transport Metabolism of lipids and lipoproteins Lipid digestion, mobilization, and transport ABCA transporters in lipid homeostasis	ABC-family proteins mediated transport ABCA transporters in lipid homeostasis
Drugs		Adenosine triphosphate
Diseases
GWAS
Protein-Protein Interactions		1 interactors: ABCG4	2 interactors: ABCG1 ZDHHC17
Entrez ID		9619	64137
HPRD ID		04355	12130
Ensembl ID		ENSG00000160179	ENSG00000172350
Uniprot IDs		P45844	Q9H172
PDB IDs
Enriched GO Terms of Interacting Partners?		Cholesterol Efflux Cholesterol Transport Sterol Transport Lipid Transport Lipid Localization	Lipoprotein Metabolic Process Detection Of Hormone Stimulus Glycoprotein Transport Response To High Density Lipoprotein Particle Negative Regulation Of Cholesterol Storage Positive Regulation Of Cholesterol Biosynthetic Process Intracellular Cholesterol Transport Intracellular Sterol Transport Positive Regulation Of Cholesterol Metabolic Process Phospholipid Homeostasis Regulation Of Cholesterol Esterification Low-density Lipoprotein Particle Remodeling Phospholipid Efflux Amyloid Precursor Protein Catabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation High-density Lipoprotein Particle Remodeling Response To Lipoprotein Particle Reverse Cholesterol Transport Positive Regulation Of Cholesterol Efflux Negative Regulation Of Lipid Storage Amyloid Precursor Protein Metabolic Process Positive Regulation Of Cholesterol Transport Lipoprotein Transport Regulation Of Cholesterol Biosynthetic Process Magnesium Ion Transport Regulation Of Cholesterol Efflux Plasma Lipoprotein Particle Remodeling Positive Regulation Of Steroid Metabolic Process Cholesterol Efflux Protein Palmitoylation Regulation Of Cholesterol Metabolic Process Regulation Of Cholesterol Transport Toxin Transport Protein Transport Regulation Of Macrophage Derived Foam Cell Differentiation Anion Homeostasis Establishment Of Protein Localization Carbohydrate Derivative Transport Regulation Of Lipid Storage Positive Regulation Of Lipid Transport Positive Regulation Of Lipid Biosynthetic Process Regulation Of Plasma Lipoprotein Particle Levels Transmembrane Transport Sterol Transport Cholesterol Transport Ion Transport Regulation Of Steroid Biosynthetic Process Cholesterol Homeostasis Protein Localization Sterol Homeostasis
Tagcloud ?		5p abcb1 abcc5 adr aza bioinformatics bisulfate bsp chemo cpg dc gastric hyper island mdr mir mirna mirnas multi opposite parent reagent restored sgc7901 silence suppressive transporters vcr	3h abca1 abcb1 abcg2 abeta abeta1 bbb bcrp brains cassette clearance clup concert deficient efflux gf120918 glycoprotein hallmark hek293 lrp mul partly perfusing perfusion probucol stably subfamily transporter
Tagcloud (Difference) ?		5p abcc5 adr aza bioinformatics bisulfate bsp chemo cpg dc gastric hyper island mdr mir mirna mirnas multi opposite parent reagent restored sgc7901 silence suppressive transporters vcr	3h abca1 abcg2 abeta abeta1 bbb bcrp brains cassette clearance clup concert deficient efflux gf120918 glycoprotein hallmark hek293 lrp mul partly perfusing perfusion probucol stably subfamily transporter
Tagcloud (Intersection) ?		abcb1