PIGS and PDYN

		PIGS	PDYN
Description		phosphatidylinositol glycan anchor biosynthesis class S	prodynorphin
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane GPI-anchor Transamidase Complex	Extracellular Region Plasma Membrane Dendrite Neuronal Cell Body Axon Terminus Hippocampal Mossy Fiber To CA3 Synapse Neuronal Dense Core Vesicle
	Molecular Function	Protein Binding	Opioid Peptide Activity Protein Binding Opioid Receptor Binding
	Biological Process	GPI Anchor Biosynthetic Process Attachment Of GPI Anchor To Protein GPI Anchored Protein Biosynthesis	Neuropeptide Signaling Pathway Chemical Synaptic Transmission Sensory Perception
Pathways		Attachment of GPI anchor to uPAR	Opioid Signalling G-protein activation Peptide ligand-binding receptors G alpha (i) signalling events
Drugs
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS			Aortic root size ( 21223598) Immune response to measles-mumps-rubella vaccine ( 24811271) Immune response to smallpox vaccine (IL-6) ( 22542470) Metabolite levels ( 23823483) Platelet count ( 29403010)
Interacting Genes		14 interacting genes: CPEB2 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP19-2 KRTAP2-3 KRTAP2-4 KRTAP6-3 KRTAP9-2 NBPF19 NOTCH2NLA TRIP6	2 interacting genes: APP NRDC
Entrez ID		94005	5173
HPRD ID		15135	08838
Ensembl ID		ENSG00000087111	ENSG00000101327
Uniprot IDs		Q8NBL9 Q96IR5 Q96S52	P01213
PDB IDs		7W72 7WLD 8IMX 8IMY	2N2F 7Y1F 8F7W 8VJU 8VJV
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament	Positive Regulation Of Membrane Protein Ectodomain Proteolysis Dendrite Membrane Regulation Of Membrane Protein Ectodomain Proteolysis Dendrite Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Tumor Necrosis Factor Production Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Nervous System Process Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Tumor Necrosis Factor Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Proteolysis Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Epidermal Growth Factor Binding GPI-anchor Transamidase Complex GPI Anchored Protein Biosynthesis Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Sarcoglycan Complex Attachment Of GPI Anchor To Protein Cell Projection Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity
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