PIGS and GGT6

		PIGS	GGT6
Description		phosphatidylinositol glycan anchor biosynthesis class S	gamma-glutamyltransferase 6
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane GPI-anchor Transamidase Complex	Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding Transferase Activity Acyltransferase Activity Hydrolase Activity Glutathione Hydrolase Activity Leukotriene C4 Gamma-glutamyl Transferase Activity
	Biological Process	GPI Anchor Biosynthetic Process Attachment Of GPI Anchor To Protein GPI Anchored Protein Biosynthesis	Glutathione Metabolic Process Glutathione Biosynthetic Process Leukotriene D4 Biosynthetic Process
Pathways		Attachment of GPI anchor to uPAR	Glutathione synthesis and recycling Aflatoxin activation and detoxification Paracetamol ADME
Drugs
Diseases
GWAS			Rheumatoid arthritis ( 28118524) Rheumatoid arthritis (rheumatoid factor and/or anti-cyclic citrullinated peptide seropositive) ( 28118524)
Interacting Genes		14 interacting genes: CPEB2 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP19-2 KRTAP2-3 KRTAP2-4 KRTAP6-3 KRTAP9-2 NBPF19 NOTCH2NLA TRIP6	10 interacting genes: ADAM33 BMP10 ENTPD3 FAIM2 FAM3C GRINA NOTCH3 SEC22A TMBIM1 TNMD
Entrez ID		94005	124975
HPRD ID		15135	08293
Ensembl ID		ENSG00000087111	ENSG00000167741
Uniprot IDs		Q8NBL9 Q96IR5 Q96S52	B4DKN3 B4DPG6 J3KPJ0 Q6P531 Q6ZPD7
PDB IDs		7W72 7WLD 8IMX 8IMY
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament	Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Calcium Channel Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Calcium Ion Transmembrane Transport Golgi Membrane Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic Signaling Pathway Calcium Ion Transport Apoptotic Signaling Pathway Negative Regulation Of Fas Signaling Pathway Apyrase Activity Regulation Of Apoptotic Signaling Pathway Endoplasmic Reticulum Cerebellar Granular Layer Development
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