DRC1 and CENPO

		DRC1	CENPO
Description		dynein regulatory complex subunit 1	centromere protein O
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Cytoskeleton Axonemal Dynein Complex Cilium Axoneme Motile Cilium Sperm Flagellum Cell Projection	Chromosome, Centromeric Region Kinetochore Inner Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Nuclear Body Mis6-Sim4 Complex
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Regulation Of Cilium Movement Single Fertilization Determination Of Left/right Symmetry Heart Development Flagellated Sperm Motility Axoneme Assembly Cilium Organization Cilium-dependent Cell Motility Protein-containing Complex Assembly Axonemal Dynein Complex Assembly Mucociliary Clearance Sperm Flagellum Assembly	Chromosome Segregation Centromere Complex Assembly
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat mass ( 28552196) Body mass index ( 29273807 26426971) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Cognitive function ( 28093568) Coronary artery disease ( 29212778) Height ( 23563607 28552196 25282103) Multiple sclerosis ( 24076602) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Trunk fat mass ( 28552196) Type 1 diabetes ( 21980299) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		1 interacting genes: GSK3A	6 interacting genes: CEP170P1 DCDC2 ERI3 FOS FOSB NECAB2
Entrez ID		92749	79172
HPRD ID		11312	14414
Ensembl ID		ENSG00000157856	ENSG00000138092
Uniprot IDs		Q96MC2	Q9BU64
PDB IDs		8J07	7PB8 7PKN 7QOO 7R5S 7R5V 7XHN 7XHO 7YWX 7YYH
Enriched GO Terms of Interacting Partners?		Negative Regulation Of UDP-glucose Catabolic Process Negative Regulation Of Muscle Cell Differentiation Mis6-Sim4 Complex Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Muscle Cell Differentiation Centromere Complex Assembly Regulation Of Glycogen (starch) Synthase Activity	Response To Corticosterone Response To Progesterone Response To Mineralocorticoid Response To Prolactin Response To Ethanol Double-stranded DNA Binding Conditioned Taste Aversion Female Pregnancy Response To Calcium Ion Response To CAMP Medium-term Memory Response To Glucocorticoid Cellular Response To Prolactin Cellular Response To Calcium Ion Axoneme Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Adenosine Receptor Signaling Pathway A2A Adenosine Receptor Binding Response To Purine-containing Compound Response To Corticosteroid Type 5 Metabotropic Glutamate Receptor Binding Cellular Response To Metal Ion Transcription Factor AP-1 Complex Cellular Response To Zinc Ion Starvation Response To Mechanical Stimulus Response To Gravity Response To Ketone Response To Steroid Hormone Kinocilium Skeletal Muscle Cell Proliferation Cellular Response To Phorbol 13-acetate 12-myristate Positive Regulation Of Glutamate Receptor Signaling Pathway Mucociliary Clearance Myoblast Proliferation Cellular Response To Parathyroid Hormone Stimulus Response To Phorbol 13-acetate 12-myristate Response To Alcohol Cilium Assembly Regulation Of Glutamate Receptor Signaling Pathway Axonemal Dynein Complex Response To Xenobiotic Stimulus Transcription By RNA Polymerase II Cilium Organization Response To Parathyroid Hormone Response To Forskolin Neural Retina Development Response To Metal Ion Behavioral Response To Cocaine Response To Morphine Negative Regulation Of Receptor Internalization
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