DRC1 and TCF23

		DRC1	TCF23
Description		dynein regulatory complex subunit 1	transcription factor 23
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Cytoskeleton Axonemal Dynein Complex Cilium Axoneme Motile Cilium Sperm Flagellum Cell Projection	Chromatin Euchromatin Nucleus
	Molecular Function	Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity
	Biological Process	Regulation Of Cilium Movement Single Fertilization Determination Of Left/right Symmetry Heart Development Flagellated Sperm Motility Axoneme Assembly Cilium Organization Cilium-dependent Cell Motility Protein-containing Complex Assembly Axonemal Dynein Complex Assembly Mucociliary Clearance Sperm Flagellum Assembly	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Positive Regulation Of Gene Expression Cell Differentiation Developmental Process Decidualization Negative Regulation Of Muscle Cell Differentiation
Pathways
Drugs
Diseases
GWAS			Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Serum metabolite levels ( 33031748) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		1 interacting genes: GSK3A	4 interacting genes: EMD FIGLA HNRNPK U2AF2
Entrez ID		92749	150921
HPRD ID		11312	18734
Ensembl ID		ENSG00000157856	ENSG00000163792
Uniprot IDs		Q96MC2	Q7RTU1
PDB IDs		8J07
Enriched GO Terms of Interacting Partners?		Negative Regulation Of UDP-glucose Catabolic Process Negative Regulation Of Muscle Cell Differentiation Mis6-Sim4 Complex Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Muscle Cell Differentiation Centromere Complex Assembly Regulation Of Glycogen (starch) Synthase Activity	Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing TMEM240-body Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Poly-pyrimidine Tract Binding Spliceosomal Complex Regulation Of RNA Splicing Positive Regulation Of Low-density Lipoprotein Particle Clearance RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Commitment Complex U2AF Complex Pre-mRNA 3'-splice Site Binding Cortical Endoplasmic Reticulum Mucociliary Clearance Cadherin Binding Spindle Pole Centrosome RNA Splicing Regulation Of MRNA Metabolic Process Random Inactivation Of X Chromosome Prp19 Complex C2H2 Zinc Finger Domain Binding Axonemal Dynein Complex U2-type Prespliceosome Oocyte Development Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Sperm Flagellum Assembly Positive Regulation Of Protein Export From Nucleus Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Regulatory NcRNA-mediated Heterochromatin Formation MRNA Processing
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