OXNAD1 and CAPNS2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		OXNAD1	CAPNS2
Description		oxidoreductase NAD binding domain containing 1	calpain small subunit 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion	Cytoplasm Cytosol Plasma Membrane Membrane Calpain Complex
	Molecular Function	Protein Binding Oxidoreductase Activity	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Metal Ion Binding
	Biological Process
Pathways			Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs
Diseases
GWAS		Night sleep phenotypes ( 27126917)	Thyroid hormone levels ( 23408906)
Interacting Genes		4 interacting genes: CAPNS2 FKBP7 FSD2 IFT20	9 interacting genes: APP ARMC10 CAPN2 CMTM5 OXNAD1 PHACTR3 PPIC PRPF31 RIN1
Entrez ID		92106	84290
HPRD ID		14446	16682
Ensembl ID		ENSG00000154814	ENSG00000256812
Uniprot IDs		C9JLB7 Q96HP4	Q96L46
PDB IDs
Enriched GO Terms of Interacting Partners?		Gamma-aminobutyric Acid:sodium:chloride Symporter Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Gamma-aminobutyric Acid Import Amino Acid:sodium Symporter Activity Gamma-aminobutyric Acid Transport Acidic Amino Acid Transport Inorganic Anion Import Across Plasma Membrane Neurotransmitter Transport Transport Across Blood-brain Barrier Amino Acid Transmembrane Transport Symporter Activity Associative Learning Taurine:sodium Symporter Activity Taurine Transmembrane Transporter Activity Opsin Transport Intraciliary Transport Particle GABA-ergic Synapse Sodium:chloride Symporter Activity Gamma-aminobutyric Acid Reuptake Alanine Transmembrane Transporter Activity Kinociliary Basal Body Amino Acid Transport COPII-coated Vesicle Budding Import Across Plasma Membrane Sodium Ion Transmembrane Transport Taurine Transmembrane Transport MRF Binding Calpain Complex Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Dendrite Terminus Opsin Binding Learning Sodium Ion Transport	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Endocytosis Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Phosphatidylcholine Biosynthetic Process Calpain Complex Protein Catabolic Process At Postsynapse Regulation Of Phosphatidylcholine Biosynthetic Process Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress SnRNP Binding U4atac SnRNP Ribonucleoprotein Complex Localization SnoRNA Localization U4atac SnRNA Binding Regulation Of Growth Rate DNA Binding Domain Binding Positive Regulation Of Growth Rate Regulation Of Interleukin-6 Production Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Spliceosomal Tri-snRNP Complex Import Into Cell Axon Choice Point Recognition U4 SnRNA Binding
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