KCNAB3 and GMDS

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KCNAB3	GMDS
Description		potassium voltage-gated channel subfamily A regulatory beta subunit 3	GDP-mannose 4,6-dehydratase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Voltage-gated Potassium Channel Activity Protein Binding Alcohol Dehydrogenase (NADP+) Activity Potassium Channel Regulator Activity Oxidoreductase Activity Transmembrane Transporter Binding	Protein Binding GDP-mannose 4,6-dehydratase Activity Lyase Activity Identical Protein Binding NADP+ Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport	Notch Signaling Pathway GDP-mannose Metabolic Process GDP-L-fucose Biosynthetic Process 'de Novo' GDP-L-fucose Biosynthetic Process
Pathways		Voltage gated Potassium channels	GDP-fucose biosynthesis
Drugs			Guanosine-5'-Diphosphate-Rhamnose Guanosine-5'-Diphosphate
Diseases
GWAS		Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Refractive error ( 32231278) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Anthropometric traits (multi-trait analysis) ( 30166351) Caudate nucleus volume ( 21502949) Coronary artery disease ( 29212778) Daytime sleep phenotypes ( 27126917) Fasting glucose ( 34074324) Fish intake frequency ( 31320941) Glaucoma (high intraocular pressure) ( 33627673) Glaucoma (low intraocular pressure) ( 33627673) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935 25173105) Haemorrhoidal disease ( 33888516) HDL cholesterol levels in HIV infection ( 33109212) Heel bone mineral density ( 30598549) Height ( 31562340) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Hip circumference adjusted for BMI ( 25673412 34021172) Impulsivity (non-planning) ( 30718321) Intraocular pressure ( 30054594 29785010 31959993 29617998) Iris heterochromicity ( 30895295) Late-onset myasthenia gravis ( 26562150) Medication use (diuretics) ( 31015401) Monobrow ( 27182965) Monobrow thickness ( 26926045) Myocardial infarction ( 33532862) Obesity-related traits ( 23251661) Optic disc size ( 31809533) Orofacial clefts ( 33137956) Pulse pressure ( 30578418) Red blood cell count ( 32888494 27863252) Refractive error ( 32231278) Response to platinum-based agents ( 22020760) Reticulocyte count ( 32888494) Sub-cortical grey matter volume ( 31530798) Urate levels ( 31578528) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		4 interacting genes: APP GMDS NEDD4L PLEKHF2	3 interacting genes: KCNAB3 NTAQ1 TNKS
Entrez ID		9196	2762
HPRD ID		04983	11925
Ensembl ID		ENSG00000170049	ENSG00000112699
Uniprot IDs		O43448	O60547
PDB IDs			1T2A 5IN4 5IN5 6GPJ 6GPK 6GPL 6Q94
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Early Endosome Membrane Axon Midline Choice Point Recognition Endosome Amylin Binding Positive Regulation Of Protein Catabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Endocytosis Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling GDP-mannose 4,6-dehydratase Activity NADP+ Binding GDP-L-fucose Biosynthetic Process 'de Novo' GDP-L-fucose Biosynthetic Process Negative Regulation Of Sodium Ion Import Across Plasma Membrane Positive Regulation Of Caveolin-mediated Endocytosis Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Negative Regulation Of Protein Localization Regulation Of Toll Signaling Pathway GDP-L-fucose Metabolic Process Negative Regulation Of Potassium Ion Export Across Plasma Membrane Axon Choice Point Recognition Regulation Of Caveolin-mediated Endocytosis Synapse Organization Heparan Sulfate Binding Signaling Receptor Activator Activity	Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric Protein-N-terminal Asparagine Amidohydrolase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Negative Regulation Of Sister Chromatid Cohesion Positive Regulation Of Telomere Capping Protein Localization To Chromosome, Telomeric Region NAD+-protein-aspartate ADP-ribosyltransferase Activity Telomerase Inhibitor Activity Regulation Of Telomere Capping Protein Auto-ADP-ribosylation NAD+-protein-glutamate ADP-ribosyltransferase Activity Alcohol Dehydrogenase (NADP+) Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Regulation Of Sister Chromatid Cohesion Protein Poly-ADP-ribosylation Pericentriolar Material Positive Regulation Of Telomere Maintenance Via Telomerase Peptidyl-threonine Phosphorylation NAD+-protein Mono-ADP-ribosyltransferase Activity Positive Regulation Of Telomere Maintenance Via Telomere Lengthening NAD+ Poly-ADP-ribosyltransferase Activity Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Mitotic Spindle Pole Regulation Of Telomere Maintenance Via Telomerase Peptidyl-serine Phosphorylation Positive Regulation Of DNA Biosynthetic Process Potassium Channel Regulator Activity
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