GMDS

Description		GDP-mannose 4,6-dehydratase
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding GDP-mannose 4,6-dehydratase Activity Lyase Activity Identical Protein Binding NADP+ Binding
	Biological Process	Notch Signaling Pathway GDP-mannose Metabolic Process GDP-L-fucose Biosynthetic Process 'de Novo' GDP-L-fucose Biosynthetic Process
Pathways		GDP-fucose biosynthesis
Drugs		Guanosine-5'-Diphosphate-Rhamnose Guanosine-5'-Diphosphate
Diseases
GWAS		Anthropometric traits (multi-trait analysis) ( 30166351) Caudate nucleus volume ( 21502949) Coronary artery disease ( 29212778) Daytime sleep phenotypes ( 27126917) Fasting glucose ( 34074324) Fish intake frequency ( 31320941) Glaucoma (high intraocular pressure) ( 33627673) Glaucoma (low intraocular pressure) ( 33627673) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935 25173105) Haemorrhoidal disease ( 33888516) HDL cholesterol levels in HIV infection ( 33109212) Heel bone mineral density ( 30598549) Height ( 31562340) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Hip circumference adjusted for BMI ( 25673412 34021172) Impulsivity (non-planning) ( 30718321) Intraocular pressure ( 30054594 29785010 31959993 29617998) Iris heterochromicity ( 30895295) Late-onset myasthenia gravis ( 26562150) Medication use (diuretics) ( 31015401) Monobrow ( 27182965) Monobrow thickness ( 26926045) Myocardial infarction ( 33532862) Obesity-related traits ( 23251661) Optic disc size ( 31809533) Orofacial clefts ( 33137956) Pulse pressure ( 30578418) Red blood cell count ( 32888494 27863252) Refractive error ( 32231278) Response to platinum-based agents ( 22020760) Reticulocyte count ( 32888494) Sub-cortical grey matter volume ( 31530798) Urate levels ( 31578528) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		3 interacting genes: KCNAB3 NTAQ1 TNKS
Entrez ID		2762
HPRD ID		11925
Ensembl ID		ENSG00000112699
Uniprot IDs		O60547
PDB IDs		1T2A 5IN4 5IN5 6GPJ 6GPK 6GPL 6Q94
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric Protein-N-terminal Asparagine Amidohydrolase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Negative Regulation Of Sister Chromatid Cohesion Positive Regulation Of Telomere Capping Protein Localization To Chromosome, Telomeric Region NAD+-protein-aspartate ADP-ribosyltransferase Activity Telomerase Inhibitor Activity Regulation Of Telomere Capping Protein Auto-ADP-ribosylation NAD+-protein-glutamate ADP-ribosyltransferase Activity Alcohol Dehydrogenase (NADP+) Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Regulation Of Sister Chromatid Cohesion Protein Poly-ADP-ribosylation Pericentriolar Material Positive Regulation Of Telomere Maintenance Via Telomerase Peptidyl-threonine Phosphorylation NAD+-protein Mono-ADP-ribosyltransferase Activity Positive Regulation Of Telomere Maintenance Via Telomere Lengthening NAD+ Poly-ADP-ribosyltransferase Activity Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Mitotic Spindle Pole Regulation Of Telomere Maintenance Via Telomerase Peptidyl-serine Phosphorylation Positive Regulation Of DNA Biosynthetic Process Potassium Channel Regulator Activity
Tagcloud ?