ZBED1 and MKKS

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZBED1	MKKS
Description		zinc finger BED-type containing 1	MKKS centrosomal shuttling protein
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Centrosome PML Body Nuclear Membrane	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Motile Cilium Ciliary Basal Body Kinociliary Basal Body
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding Protein Dimerization Activity SUMO Ligase Activity Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Protein Binding ATP Binding Unfolded Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Sumoylation Host-mediated Suppression Of Viral Genome Replication Positive Regulation Of Transcription By RNA Polymerase II Protein Autosumoylation	Heart Looping Developmental Process Involved In Reproduction Protein Folding Spermatid Development Determination Of Left/right Symmetry Heart Development Visual Perception Sensory Perception Of Smell Gonad Development Gene Expression Negative Regulation Of Gene Expression Artery Smooth Muscle Contraction Striatum Development Hippocampus Development Cerebral Cortex Development Negative Regulation Of Actin Filament Polymerization Melanosome Transport Developmental Process Leptin-mediated Signaling Pathway Social Behavior Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Positive Regulation Of Multicellular Organism Growth Vasodilation Response To Leptin Fat Cell Differentiation Photoreceptor Cell Maintenance Negative Regulation Of Blood Pressure Intracellular Transport Animal Organ Development System Development Brain Morphogenesis Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Chaperone-mediated Protein Complex Assembly Cartilage Development Regulation Of Stress Fiber Assembly Pigment Granule Aggregation In Cell Center Convergent Extension Involved In Gastrulation Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Face Development Response To Inositol Non-motile Cilium Assembly
Pathways		SUMOylation of chromatin organization proteins	BBSome-mediated cargo-targeting to cilium
Drugs
Diseases			46,XX disorders of sex development (Other), including: Mullerian aplasia and hyperandrogenism; McKusick-Kaufman syndrome Bardet-Biedl syndrome (BBS)
GWAS
Interacting Genes		61 interacting genes: AIRIM AMOTL2 ATRX CBX4 CCDC13 CDC37 CTNNAL1 DGCR6 EFHC1 FABP4 FAM124B FANCG FNDC11 GGACT GORASP2 GPN1 GPSM1 KDM1A KIFC3 KLHL40 LCN2 LNX1 LRRC20 MAD2L2 MAGEB2 MKKS MLH1 MPST MYO15B NCDN NIF3L1 NIP7 NTAQ1 NUDT18 PAX6 PIAS1 PIAS2 PICK1 POLE2 POLR1C PRKAA1 PRKAR1A PSAP RANBP9 RENBP RIN1 SORBS3 SPEF1 SSX2 SUMO1 SUMO2 TDP2 TRAPPC2B TRIML2 TTC23 TTR UBE2I UCHL5 USP2 ZHX1 ZNF451	4 interacting genes: APP CDR2 PTN ZBED1
Entrez ID		9189	8195
HPRD ID		02170	05356
Ensembl ID		ENSG00000214717	ENSG00000125863
Uniprot IDs		O96006	B7Z3W9 Q9NPJ1
PDB IDs		2CT5
Enriched GO Terms of Interacting Partners?		Protein Sumoylation PML Body SUMO Transferase Activity SUMO Ligase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Presynaptic Cytosol Postsynaptic Cytosol Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Activity Negative Regulation Of Metabolic Process Post-translational Protein Modification Protein Binding DNA Repair Ubiquitin Protein Ligase Binding Organelle Organization Small Protein Activating Enzyme Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Stress Nuclear Body Regulation Of Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Modification Process Nucleoplasm Enzyme Binding Error-prone Translesion Synthesis Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cytoplasm RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleotide-activated Protein Kinase Complex Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Response To Radiation Response To Light Stimulus Regulation Of RNA Metabolic Process Microtubule Cytoskeleton Organization Nucleus DNA Metabolic Process	Negative Regulation Of Long-term Synaptic Potentiation Response To Auditory Stimulus Molecular Function Activator Activity Dendrite Membrane Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Dendrite Development Phospholipase C-activating Endothelin Receptor Signaling Pathway Protein Autosumoylation Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Leukocyte Chemotaxis Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Interleukin-15 Receptor Activity Interleukin-2 Binding Interleukin-2 Receptor Activity Interleukin-2 Receptor Complex Dendrite Regeneration Ossification Involved In Bone Remodeling Selenium Compound Metabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Memory Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Modulation Of Chemical Synaptic Transmission Axon Midline Choice Point Recognition Recycling Endosome Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Positive Regulation Of Chemotaxis
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