SLC24A1 and PACS1

		SLC24A1	PACS1
Description		solute carrier family 24 member 1	phosphofurin acidic cluster sorting protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Outer Membrane Neuronal Cell Body	Golgi Apparatus Cytosol COPI-coated Vesicle
	Molecular Function	Calcium Channel Activity Protein Binding Calcium, Potassium:sodium Antiporter Activity Symporter Activity Antiporter Activity	Protein Binding Transmembrane Transporter Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Visual Perception Response To Light Intensity Sodium Ion Transmembrane Transport Transmembrane Transport Long-term Synaptic Potentiation Long-term Synaptic Depression Calcium Ion Transmembrane Transport Potassium Ion Transmembrane Transport Calcium Ion Import Across Plasma Membrane	Lymphocyte Homeostasis Protein Localization To Golgi Apparatus Protein Localization To Plasma Membrane
Pathways		Activation of the phototransduction cascade Sodium/Calcium exchangers Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D)	Nef mediated downregulation of MHC class I complex cell surface expression
Drugs
Diseases
GWAS		Hemoglobin levels ( 32327693) Iron status biomarkers (ferritin levels) ( 33536631) Logical memory (delayed recall) in normal cognition ( 29274321) Mean corpuscular hemoglobin ( 20139978)	Acne (severe) ( 24927181) Bipolar disorder ( 21926972 31043756 33263727 34002096) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Electroencephalogram traits ( 25387704) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494) Obesity (early onset extreme) ( 23563609) Serum uric acid levels ( 32514006) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		1 interacting genes: CNGA1	10 interacting genes: CLCN7 CSNK2A1 FURIN GGA3 IGF2R JUN PKD2 PPP2CA PPP2CB VAMP4
Entrez ID		9187	55690
HPRD ID		04685	06320
Ensembl ID		ENSG00000074621	ENSG00000175115
Uniprot IDs		B4DUG1 B4E1W0 F5H127 F5H483 O60721	Q6VY07
PDB IDs
Enriched GO Terms of Interacting Partners?		Intracellular Cyclic Nucleotide Activated Cation Channel Complex Intracellularly CAMP-activated Cation Channel Activity CGMP Binding Intracellularly Cyclic Nucleotide-activated Monoatomic Cation Channel Activity Photoreceptor Outer Segment Membrane Intracellularly CGMP-activated Cation Channel Activity Rod Photoreceptor Outer Segment HMG Box Domain Binding Response To Gonadotropin-releasing Hormone CAMP Response Element Binding Pristanate-CoA Ligase Activity Phytanate-CoA Ligase Activity Fatty Acid Transmembrane Transporter Activity Very Long-chain Fatty Acid-CoA Ligase Activity Very Long-chain Fatty Acid Catabolic Process Methyl-branched Fatty Acid Metabolic Process Long-chain Fatty Acid-CoA Ligase Activity Cholate-CoA Ligase Activity Arachidonate-CoA Ligase Activity Fatty Acid Alpha-oxidation Lipid Import Into Cell Long-chain Fatty Acid Import Into Cell Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase COPI-coated Vesicle Long-chain Fatty Acid Transmembrane Transporter Activity CAMP Binding Bile Acid Biosynthetic Process Fatty-acyl-CoA Biosynthetic Process Protein Localization To Golgi Apparatus BHLH Transcription Factor Binding	Response To Metal Ion Golgi To Plasma Membrane Transport Trans-Golgi Network Post-Golgi Vesicle-mediated Transport Trans-Golgi Network Transport Vesicle Liver Development Transforming Growth Factor Beta Receptor Signaling Pathway FAR/SIN/STRIPAK Complex Protein Phosphatase Type 2A Complex Response To Lead Ion Negative Regulation Of DNA Repair Vacuolar Transport Negative Regulation Of Double-strand Break Repair Vesicle-mediated Transport To The Plasma Membrane Response To Calcium Ion Host-mediated Activation Of Viral Process Phosphoprotein Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Transmembrane Transporter Binding Cellular Response To Fluid Shear Stress Metanephric Cortical Collecting Duct Development Response To Fluid Shear Stress Metanephric Cortex Development Metanephric Distal Tubule Development RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Golgi To Plasma Membrane Protein Transport Homocarnosine Synthase Activity Carnosine Synthase Activity Carnosine Biosynthetic Process Kinesin I Complex Tau Protein Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Chloride:proton Antiporter Activity Lysosome Positive Regulation Of Protein Catabolic Process Protein Targeting To Vacuole Rab GDP-dissociation Inhibitor Activity Leading Edge Cell Differentiation Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Peptidase Activity Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Polycystin Complex Metanephric Smooth Muscle Tissue Development
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