SLFN11 and CSF3

		SLFN11	CSF3
Description		schlafen family member 11	colony stimulating factor 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Site Of DNA Damage	Extracellular Region Extracellular Space Lysosomal Lumen Endocytic Vesicle Lumen
	Molecular Function	TRNA Binding Nucleotide Binding DNA Binding RNA Binding Catalytic Activity Helicase Activity Nuclease Activity Endonuclease Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity	Signaling Receptor Binding Cytokine Activity Granulocyte Colony-stimulating Factor Receptor Binding Growth Factor Activity Enzyme Binding
	Biological Process	Immune System Process Chromatin Remodeling DNA Damage Response Negative Regulation Of DNA Replication Replication Fork Arrest Defense Response To Virus Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Immune Response Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Actin Filament Polymerization Granulocyte Differentiation Granulocyte Colony-stimulating Factor Signaling Pathway Response To Ethanol Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Regulation Of Actin Filament Organization
Pathways			Other interleukin signaling Interleukin-10 signaling Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling
Drugs
Diseases
GWAS		Barrett's esophagus x pack-years of smoking exposure interaction ( 29551738)	Asthma ( 31619474) Bipolar disorder ( 31043756) Composite immunoglobulin trait (IgA x IgG) ( 28628107) Creatine kinase levels ( 29403010) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 27863252 32888494) Mitochondrial DNA copy number ( 30704525) Myeloid white cell count ( 27863252) Neutrophil count ( 20172861 32888494 27863252 25096241) Neutrophil percentage of white cells ( 27863252 32888494) Rheumatoid arthritis ( 24390342 30423114) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 20139978 32888494 29403010 28158719 27863252 21738480) White blood cell count (neutrophil) ( 28158719) White blood cell types ( 21738478)
Interacting Genes		1 interacting genes: CEBPA	6 interacting genes: CSF3R ELANE PARVG S100A6 S100P TBX3
Entrez ID		91607	1440
HPRD ID		08178	00736
Ensembl ID		ENSG00000172716	ENSG00000108342
Uniprot IDs		Q7Z7L1	P09919 Q6FH65 Q8N4W3
PDB IDs		7ZEL 7ZEP 7ZES 9ERD 9ERE 9ERF 9GMW 9GMX	1CD9 1GNC 1PGR 1RHG 2D9Q 5GW9 5ZO6
Enriched GO Terms of Interacting Partners?		Granulocyte Differentiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Myeloid Leukocyte Differentiation Granulocyte Colony-stimulating Factor Receptor Binding Response To Vitamin B2 Myeloid Cell Differentiation C/EBP Complex Leukocyte Differentiation Cytokine-mediated Signaling Pathway CHOP-C/EBP Complex Cellular Response To Cytokine Stimulus Regulation Of Hemopoiesis White Fat Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Granulocyte Colony-stimulating Factor Signaling Pathway Response To Phenylpropanoid Fat Cell Proliferation Response To Peptide Response To Cytokine Urea Metabolic Process HMG Box Domain Binding Urea Cycle STAT Family Protein Binding Response To Lithium Ion Transcription By RNA Polymerase I Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Interleukin-6-mediated Signaling Pathway Osteoblast Development Response To Lipid Endocytic Vesicle Lumen Regulation Of Cell Development Positive Regulation Of Cell Differentiation Hematopoietic Stem Cell Proliferation Embryonic Placenta Development Epithelial Cell Maturation Negative Regulation Of Stem Cell Proliferation Brown Fat Cell Differentiation Positive Regulation Of Macrophage Activation Integrated Stress Response Signaling Acute-phase Response Macrophage Differentiation Response To Dexamethasone Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Developmental Process Regulation Of Multicellular Organismal Development	Positive Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Negative Regulation Of Cell Cycle G1/S Phase Transition Y Chromosome Positive Regulation Of Heterochromatin Formation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cyclin A1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Cellular Senescence Granulocyte Colony-stimulating Factor Binding Cytokine Binding Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Negative Regulation Of Chemotaxis Neutrophil-mediated Killing Of Fungus Positive Regulation Of Interleukin-8 Production Protein Homodimerization Activity Quinone Catabolic Process Melatonin Binding Oxidoreductase Activity, Acting On Other Nitrogenous Compounds As Donors Dihydronicotinamide Riboside Quinone Reductase Activity Resveratrol Binding Calcium-dependent Protein Binding Follicle-stimulating Hormone Secretion Atrioventricular Bundle Cell Differentiation Limbic System Development Ureteric Peristalsis Hepatoblast Differentiation Positive Regulation Of Cellular Response To Oxidative Stress Acetylspermidine Deacetylase Activity Polyamine Deacetylation Spermidine Deacetylation Peroxidase Inhibitor Activity Negative Regulation Of Aggrephagy Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Tubulin Deacetylase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Chromatin Organization Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Regulation Of Interleukin-8 Production Antibacterial Peptide Biosynthetic Process NAD(P)H Dehydrogenase (quinone) Activity Nitric-oxide Synthase Activity Tetrahydrobiopterin Binding Mammary Placode Formation His-Purkinje System Cell Differentiation Specification Of Animal Organ Position
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