SLFN11

Description		schlafen family member 11
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Site Of DNA Damage
	Molecular Function	TRNA Binding Nucleotide Binding DNA Binding RNA Binding Catalytic Activity Helicase Activity Nuclease Activity Endonuclease Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity
	Biological Process	Immune System Process Chromatin Remodeling DNA Damage Response Negative Regulation Of DNA Replication Replication Fork Arrest Defense Response To Virus Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Drugs
Diseases
GWAS		Barrett's esophagus x pack-years of smoking exposure interaction ( 29551738)
Novel Interacting Genes		1 novel interacting genes: CSF3
Interacting Genes		1 interacting genes: CEBPA
Entrez ID		91607
HPRD ID		08178
Ensembl ID		ENSG00000172716
Uniprot IDs		Q7Z7L1
PDB IDs		7ZEL 7ZEP 7ZES 9ERD 9ERE 9ERF 9GMW 9GMX
Enriched GO Terms of Interacting Partners?		Granulocyte Differentiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Myeloid Leukocyte Differentiation Granulocyte Colony-stimulating Factor Receptor Binding Response To Vitamin B2 Myeloid Cell Differentiation C/EBP Complex Leukocyte Differentiation Cytokine-mediated Signaling Pathway CHOP-C/EBP Complex Cellular Response To Cytokine Stimulus Regulation Of Hemopoiesis White Fat Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Granulocyte Colony-stimulating Factor Signaling Pathway Response To Phenylpropanoid Fat Cell Proliferation Response To Peptide Response To Cytokine Urea Metabolic Process HMG Box Domain Binding Urea Cycle STAT Family Protein Binding Response To Lithium Ion Transcription By RNA Polymerase I Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Interleukin-6-mediated Signaling Pathway Osteoblast Development Response To Lipid Endocytic Vesicle Lumen Regulation Of Cell Development Positive Regulation Of Cell Differentiation Hematopoietic Stem Cell Proliferation Embryonic Placenta Development Epithelial Cell Maturation Negative Regulation Of Stem Cell Proliferation Brown Fat Cell Differentiation Positive Regulation Of Macrophage Activation Integrated Stress Response Signaling Acute-phase Response Macrophage Differentiation Response To Dexamethasone Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Developmental Process Regulation Of Multicellular Organismal Development
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