MTRFR and KDM2B

		MTRFR	KDM2B
Description		mitochondrial translation release factor in rescue	lysine demethylase 2B
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Nucleus Nucleoplasm Chromosome Nucleolus PcG Protein Complex
	Molecular Function	TRNA Binding RNA Binding Translation Release Factor Activity Protein Binding Translation Release Factor Activity, Codon Specific Ribosomal Large Subunit Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Transcription Coregulator Activity RNA Binding Protein Binding Zinc Ion Binding Oxidoreductase Activity RRNA Binding Histone Demethylase Activity Unmethylated CpG Binding Metal Ion Binding Dioxygenase Activity Histone H3K36 Demethylase Activity Histone H3K36me/H3K36me2 Demethylase Activity
	Biological Process	Translation Translational Termination Rescue Of Stalled Ribosome	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Spermatogenesis Midbrain-hindbrain Boundary Morphogenesis Fourth Ventricle Development Lateral Ventricle Development Third Ventricle Development Initiation Of Neural Tube Closure Positive Regulation Of Cell Growth Forebrain Development Midbrain Development Hindbrain Development Negative Regulation Of Neuron Apoptotic Process Embryonic Camera-type Eye Morphogenesis Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		Mitochondrial ribosome-associated quality control	HDMs demethylate histones
Drugs
Diseases		Combined oxidative phosphorylation deficiency (COXPD)
GWAS			Adult body size ( 32376654) Fasting glucose ( 34059833) Hand grip strength ( 29691431) Lymphocyte percentage of white cells ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		2 interacting genes: APP CDK2	7 interacting genes: CEBPE CREBBP FOS H3C1 KAT5 LZTR1 UBE2D1
Entrez ID		91574	84678
HPRD ID		08791	12362
Ensembl ID		ENSG00000130921	ENSG00000089094
Uniprot IDs		Q9H3J6	B4DSN4 Q8NHM5
PDB IDs		7A5H	4O64 5JH5 6BVA 8HCU
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Chromatin Remodeling Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Reproductive Process Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Chromatin Organization Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Initiation Of Neural Tube Closure Midbrain-hindbrain Boundary Morphogenesis Fourth Ventricle Development Negative Regulation Of Chondrocyte Development Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling X Chromosome Histone H3K36me/H3K36me2 Demethylase Activity Negative Regulation Of Bone Mineralization Involved In Bone Maturation Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Third Ventricle Development Regulation Of Spontaneous Synaptic Transmission Chromatin Organization NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity	Peptide Lactyltransferase (CoA-dependent) Activity Cellular Response To Nutrient Levels Peptidyl-lysine Acetylation Acetyltransferase Activity Histone Acetyltransferase Complex Response To Nutrient Levels Protein-lysine-acetyltransferase Activity Histone Acetyltransferase Activity Protein Acetylation Integrated Stress Response Signaling Transcription Regulator Complex Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Macromolecule Metabolic Process Medium-term Memory Cellular Response To Prolactin Histone H2AK5 Acetyltransferase Activity Positive Regulation Of DNA Recombination Organelle Disassembly Regulation Of Double-strand Break Repair Via Homologous Recombination Intracellular Signal Transduction Histone H3K27 Acetyltransferase Activity Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Crotonyltransferase Activity Chromatin Cellular Response To Lipid Positive Regulation Of Double-strand Break Repair Chromatin Binding Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Response To Radiation Response To Prolactin Conditioned Taste Aversion Histone H2A Acetyltransferase Activity Translation Release Factor Activity, Codon Specific Nucleosome RNA Polymerase II Transcription Regulator Complex Piccolo Histone Acetyltransferase Complex Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Transcription By RNA Polymerase II Myeloid Leukocyte Differentiation Regulation Of DNA Recombination MRF Binding Regulation Of Double-strand Break Repair Recombinational Repair Positive Regulation Of DNA Repair Acyltransferase Activity Positive Regulation Of Aggrephagy Transcription Factor AP-1 Complex Cellular Response To Zinc Ion Starvation
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