KDM2B

Description		lysine demethylase 2B
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus PcG Protein Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Transcription Coregulator Activity RNA Binding Protein Binding Zinc Ion Binding Oxidoreductase Activity RRNA Binding Histone Demethylase Activity Unmethylated CpG Binding Metal Ion Binding Dioxygenase Activity Histone H3K36 Demethylase Activity Histone H3K36me/H3K36me2 Demethylase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Spermatogenesis Midbrain-hindbrain Boundary Morphogenesis Fourth Ventricle Development Lateral Ventricle Development Third Ventricle Development Initiation Of Neural Tube Closure Positive Regulation Of Cell Growth Forebrain Development Midbrain Development Hindbrain Development Negative Regulation Of Neuron Apoptotic Process Embryonic Camera-type Eye Morphogenesis Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		HDMs demethylate histones
Drugs
Diseases
GWAS		Adult body size ( 32376654) Fasting glucose ( 34059833) Hand grip strength ( 29691431) Lymphocyte percentage of white cells ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Neutrophil percentage of white cells ( 32888494)
Novel Interacting Genes		2 novel interacting genes: MTRFR TCTN2
Interacting Genes		7 interacting genes: CEBPE CREBBP FOS H3C1 KAT5 LZTR1 UBE2D1
Entrez ID		84678
HPRD ID		12362
Ensembl ID		ENSG00000089094
Uniprot IDs		B4DSN4 Q8NHM5
PDB IDs		4O64 5JH5 6BVA 8HCU
Enriched GO Terms of Interacting Partners?		Peptide Lactyltransferase (CoA-dependent) Activity Cellular Response To Nutrient Levels Peptidyl-lysine Acetylation Acetyltransferase Activity Histone Acetyltransferase Complex Response To Nutrient Levels Protein-lysine-acetyltransferase Activity Histone Acetyltransferase Activity Protein Acetylation Integrated Stress Response Signaling Transcription Regulator Complex Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Macromolecule Metabolic Process Medium-term Memory Cellular Response To Prolactin Histone H2AK5 Acetyltransferase Activity Positive Regulation Of DNA Recombination Organelle Disassembly Regulation Of Double-strand Break Repair Via Homologous Recombination Intracellular Signal Transduction Histone H3K27 Acetyltransferase Activity Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Crotonyltransferase Activity Chromatin Cellular Response To Lipid Positive Regulation Of Double-strand Break Repair Chromatin Binding Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Response To Radiation Response To Prolactin Conditioned Taste Aversion Histone H2A Acetyltransferase Activity Translation Release Factor Activity, Codon Specific Nucleosome RNA Polymerase II Transcription Regulator Complex Piccolo Histone Acetyltransferase Complex Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Transcription By RNA Polymerase II Myeloid Leukocyte Differentiation Regulation Of DNA Recombination MRF Binding Regulation Of Double-strand Break Repair Recombinational Repair Positive Regulation Of DNA Repair Acyltransferase Activity Positive Regulation Of Aggrephagy Transcription Factor AP-1 Complex Cellular Response To Zinc Ion Starvation
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