CCDC74B and HENMT1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CCDC74B	HENMT1
Description		coiled-coil domain containing 74B	HEN methyltransferase 1
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Cytoplasm P Granule
	Molecular Function	Protein Binding	RNA Binding Protein Binding Methyltransferase Activity O-methyltransferase Activity RNA Methyltransferase Activity Transferase Activity Metal Ion Binding Small RNA 2'-O-methyltransferase Activity
	Biological Process		RNA Methylation SiRNA Processing Regulatory NcRNA-mediated Gene Silencing Methylation PiRNA Processing
Pathways			PIWI-interacting RNA (piRNA) biogenesis
Drugs
Diseases
GWAS
Interacting Genes		7 interacting genes: ABI2 BANP HENMT1 KDM1A MLH1 SCNM1 UBASH3B	3 interacting genes: CCDC74B INCA1 TRAF2
Entrez ID		91409	113802
HPRD ID		08534	08086
Ensembl ID		ENSG00000152076	ENSG00000162639
Uniprot IDs		Q96LY2	Q5T8I9
PDB IDs			4XCX 5WY0
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Apoptotic Signaling Pathway TORC2 Complex Disassembly TRAF2-GSTP1 Complex Regulation Of Protein Serine/threonine Kinase Activity TORC1 Complex Assembly CD40 Receptor Binding Regulation Of Protein Kinase Activity Sphingolipid Binding Regulation Of Kinase Activity IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex CD27 Signaling Pathway Thioesterase Binding CD40 Receptor Complex Regulation Of Apoptotic Signaling Pathway Regulation Of Protein Phosphorylation CD40 Signaling Pathway Protein-containing Complex Binding Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Phosphorylation Apoptotic Signaling Pathway Tumor Necrosis Factor Binding Tumor Necrosis Factor Receptor Superfamily Binding Interleukin-17-mediated Signaling Pathway Negative Regulation Of Cyclin-dependent Protein Kinase Activity Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of JUN Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Positive Regulation Of Programmed Cell Death TORC2 Signaling Cellular Response To Nitric Oxide Positive Regulation Of Apoptotic Process Regulation Of Catalytic Activity Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Mitogen-activated Protein Kinase Kinase Kinase Binding Cellular Response To Reactive Nitrogen Species Regulation Of Phosphorus Metabolic Process Response To Nitric Oxide Programmed Necrotic Cell Death Regulation Of Protein Modification Process Positive Regulation Of T Cell Cytokine Production Tumor Necrosis Factor Receptor Binding Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Protein Serine/threonine Kinase Activity Cyclin Binding Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of MAP Kinase Activity Positive Regulation Of Interleukin-2 Production
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