GYG2 and GYG1

Number of citations: 106 (PubMedID 35271311)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vitro, in vivo)

		GYG2	GYG1
Name		glycogenin 2	glycogenin 1
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Extracellular Region Nucleus Cytoplasm Cytosol Membrane Secretory Granule Lumen Lysosomal Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Glycogenin Glucosyltransferase Activity Transferase Activity Glycosyltransferase Activity Metal Ion Binding	Protein Binding Glycogenin Glucosyltransferase Activity Transferase Activity Glycosyltransferase Activity Manganese Ion Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Glycogen Biosynthetic Process	Glycogen Biosynthetic Process
Pathways		Glycogen synthesis Glycogen storage disease type 0 (liver GYS2) Glycogen storage disease type IV (GBE1) Glycogen breakdown (glycogenolysis)	Glycogen synthesis Myoclonic epilepsy of Lafora Glycogen storage disease type XV (GYG1) Glycogen storage disease type 0 (muscle GYS1) Glycogen storage disease type II (GAA) Neutrophil degranulation Glycogen breakdown (glycogenolysis) Glycogen breakdown (glycogenolysis)
Drugs		None	Uridine diphosphate glucose Uridine-5'-Diphosphate
GWAS		No GWAS studies recorded	Diverticular disease ( 30177863 )
Interacting Genes		4 interacting genes: APP GYG1 GYS1 IKBKG	7 interacting genes: C1QTNF9 CD6 CMSS1 GYG2 GYS1 POM121 TRIM7
Entrez ID		8908	2992
HPRD ID		02185	06805
Ensembl ID		ENSG00000056998	ENSG00000163754
Uniprot IDs		A8K8Y1 B3KUV6 O15488 Q1ZYL7	P46976
PDB IDs		4UEG	3Q4S 3QVB 3RMV 3RMW 3T7M 3T7N 3T7O 3U2T 3U2U 3U2V 3U2W 3U2X 6EQJ 6EQL 7OVX 7Q0B 7Q0S 7Q12 7Q13 7ZBN 8CVX 8CVY 8CVZ
GO Terms Enriched among Interactors		Glycogen Biosynthetic Process Polysaccharide Biosynthetic Process Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Glycogen Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress Protein Homodimerization Activity Carbohydrate Biosynthetic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Intrinsic Apoptotic Signaling Pathway Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Glycogenin Glucosyltransferase Activity Glycosyltransferase Activity Energy Derivation By Oxidation Of Organic Compounds Alpha-1,4-glucan Glucosyltransferase (UDP-glucose Donor) Activity Glycogen Synthase Activity, Transferring Glucose-1-phosphate Linear Polyubiquitin Binding Positive Regulation Of Proteolysis Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition IkappaB Kinase Complex	Glycogen Biosynthetic Process Polysaccharide Biosynthetic Process Glycogen Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process Glycogen Synthase Activity, Transferring Glucose-1-phosphate Carbohydrate Biosynthetic Process Glycogenin Glucosyltransferase Activity Alpha-1,4-glucan Glucosyltransferase (UDP-glucose Donor) Activity Lipoteichoic Acid Binding Glycosyltransferase Activity Energy Derivation By Oxidation Of Organic Compounds D-glucose Binding