RNASET2 and CEP43

		RNASET2	CEP43
Description		ribonuclease T2	centrosomal protein 43
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Mitochondrion Mitochondrial Intermembrane Space Lysosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Nucleus Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Cytoskeleton Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity RNA Nuclease Activity Hydrolase Activity Lyase Activity Ribonuclease T2 Activity	Protein Binding Protein Kinase Binding Protein Tyrosine Kinase Inhibitor Activity Protein Homodimerization Activity
	Biological Process	Immune System Process RNA Catabolic Process Innate Immune Response	Negative Regulation Of Protein Kinase Activity Positive Regulation Of Cell Population Proliferation Cell Projection Organization Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Microtubule Anchoring
Pathways		Neutrophil degranulation	Signaling by cytosolic FGFR1 fusion mutants Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Signaling by FGFR1 in disease AURKA Activation by TPX2
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Diseases		Cystic leukoencephalopathy without megalencephaly
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Autoimmune thyroid disease ( 32581359) Crohn's disease ( 23850713 28067908) Endometrial cancer ( 24096698) Graves' disease ( 21841780) Huntington's disease progression ( 28642124) Inflammatory bowel disease ( 23128233 28067908) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Smooth-surface caries ( 24556642) Spontaneous preterm birth (preterm birth) ( 25599974) Type 1 diabetes in high risk HLA genotype individuals (time to event) ( 29310926) Vitiligo ( 20526339 27723757)
Interacting Genes		1 interacting genes: UBC	4 interacting genes: NAGK OGT PPP2R1B S100A6
Entrez ID		8635	11116
HPRD ID		10197	10392
Ensembl ID		ENSG00000026297	ENSG00000213066
Uniprot IDs		O00584	A0A087WV25 B4DH64 O95684
PDB IDs		3T0O	2D68
Enriched GO Terms of Interacting Partners?			Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Ribonuclease T2 Activity N-acetylglucosamine Kinase Activity Muramyl Dipeptide Kinase Activity
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