MASTL and GPR158

		MASTL	GPR158
Description		microtubule associated serine/threonine kinase like	G protein-coupled receptor 158
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytoskeleton Microtubule Cytoskeleton Cleavage Furrow	Nucleus Plasma Membrane Membrane Presynaptic Membrane Cell Projection Synapse Postsynaptic Membrane Postsynaptic Density Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding Kinase Activity Transferase Activity Transmembrane Transporter Binding Protein Phosphatase 2A Binding Protein Serine Kinase Activity	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Enzyme Activator Activity G Protein-coupled Glycine Receptor Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle DNA Damage Response Female Meiosis II Regulation Of Mitotic Cell Cycle Intracellular Signal Transduction Cell Division Regulation Of Cell Cycle	Positive Regulation Of Neurotransmitter Secretion Signal Transduction G Protein-coupled Receptor Signaling Pathway Brain Development Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Synapse Organization Cognition Protein Localization To Plasma Membrane
Pathways		MASTL Facilitates Mitotic Progression MASTL Facilitates Mitotic Progression
Drugs
Diseases		Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
GWAS		Plateletcrit ( 27863252 32888494) Squamous cell lung carcinoma ( 28604730)	Carboplatin disposition in epthelial ovarian cancer ( 29367611) Central corneal thickness ( 32528159) Cerebellum white matter volume ( 31530798) Diverticular disease ( 30177863 30661054) Energy expenditure (24h) ( 28476931) Hepatitis C (spontaneous viral clearance) ( 30593799) Immune response to smallpox vaccine (IL-6) ( 22542470) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 29235454 29617998) QRS duration in Tripanosoma cruzi seropositivity ( 24324551)
Interacting Genes		1 interacting genes: CDC42
Entrez ID		84930	57512
HPRD ID		10499	13601
Ensembl ID		ENSG00000120539	ENSG00000151025
Uniprot IDs		Q96GX5	Q5T848
PDB IDs		5LOH 8V5H	7EWL 7EWP 7EWR 7SHE 7SHF
Enriched GO Terms of Interacting Partners?		Apolipoprotein A-I Receptor Binding Endothelin Receptor Signaling Pathway Involved In Heart Process Neuropilin Signaling Pathway Regulation Of Synapse Organization GBD Domain Binding Storage Vacuole G Protein-coupled Glycine Receptor Activity Leading Edge Membrane Thioesterase Binding Positive Regulation Of Pinocytosis Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Neuron Fate Determination Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Establishment Of Golgi Localization Golgi Transport Complex Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Positive Regulation Of Pseudopodium Assembly Endothelin Receptor Signaling Pathway Regulation Of Attachment Of Spindle Microtubules To Kinetochore Establishment Of Apical/basal Cell Polarity Dendritic Cell Migration G Protein-coupled Receptor Signaling Pathway Golgi Localization Positive Regulation Of Transport Establishment Of Monopolar Cell Polarity GTP-dependent Protein Binding Heart Contraction Cardiac Conduction System Development Embryonic Heart Tube Development Dendritic Spine Morphogenesis Establishment Of Epithelial Cell Apical/basal Polarity Filopodium Assembly Establishment Or Maintenance Of Monopolar Cell Polarity Cell Migration Involved In Heart Development Polarized Epithelial Cell Differentiation Positive Regulation Of Neurotransmitter Secretion Positive Regulation Of Lamellipodium Assembly Spindle Midzone Nuclear Migration Establishment Of Epithelial Cell Polarity Positive Regulation Of Filopodium Assembly Phagocytosis, Engulfment Nucleus Localization Heart Process Dendritic Spine Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Lamellipodium Organization Macrophage Differentiation Neuron Projection Organization	Hypoxanthine Phosphoribosyltransferase Activity Guanine Salvage Female Meiosis II T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Purine Ribonucleoside Salvage Guanine Metabolic Process GMP Catabolic Process Purine Nucleobase Biosynthetic Process Microtubule Cytoskeleton Establishment Of Left/right Asymmetry Axonemal B Tubule Inner Sheath 9+0 Motile Cilium Purine Nucleoside Monophosphate Catabolic Process Nucleoside Salvage Fatty-acyl-CoA Binding T Cell Receptor Complex Purine Nucleobase Metabolic Process Female Meiotic Nuclear Division Pexophagy
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