MASTL

Description		microtubule associated serine/threonine kinase like
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytoskeleton Microtubule Cytoskeleton Cleavage Furrow
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding Kinase Activity Transferase Activity Transmembrane Transporter Binding Protein Phosphatase 2A Binding Protein Serine Kinase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle DNA Damage Response Female Meiosis II Regulation Of Mitotic Cell Cycle Intracellular Signal Transduction Cell Division Regulation Of Cell Cycle
Pathways		MASTL Facilitates Mitotic Progression MASTL Facilitates Mitotic Progression
Drugs
Diseases		Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
GWAS		Plateletcrit ( 27863252 32888494) Squamous cell lung carcinoma ( 28604730)
Novel Interacting Genes		1 novel interacting genes: GPR158
Interacting Genes		1 interacting genes: CDC42
Entrez ID		84930
HPRD ID		10499
Ensembl ID		ENSG00000120539
Uniprot IDs		Q96GX5
PDB IDs		5LOH 8V5H
Enriched GO Terms of Interacting Partners?		Apolipoprotein A-I Receptor Binding Endothelin Receptor Signaling Pathway Involved In Heart Process Neuropilin Signaling Pathway Regulation Of Synapse Organization GBD Domain Binding Storage Vacuole G Protein-coupled Glycine Receptor Activity Leading Edge Membrane Thioesterase Binding Positive Regulation Of Pinocytosis Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Neuron Fate Determination Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Establishment Of Golgi Localization Golgi Transport Complex Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Positive Regulation Of Pseudopodium Assembly Endothelin Receptor Signaling Pathway Regulation Of Attachment Of Spindle Microtubules To Kinetochore Establishment Of Apical/basal Cell Polarity Dendritic Cell Migration G Protein-coupled Receptor Signaling Pathway Golgi Localization Positive Regulation Of Transport Establishment Of Monopolar Cell Polarity GTP-dependent Protein Binding Heart Contraction Cardiac Conduction System Development Embryonic Heart Tube Development Dendritic Spine Morphogenesis Establishment Of Epithelial Cell Apical/basal Polarity Filopodium Assembly Establishment Or Maintenance Of Monopolar Cell Polarity Cell Migration Involved In Heart Development Polarized Epithelial Cell Differentiation Positive Regulation Of Neurotransmitter Secretion Positive Regulation Of Lamellipodium Assembly Spindle Midzone Nuclear Migration Establishment Of Epithelial Cell Polarity Positive Regulation Of Filopodium Assembly Phagocytosis, Engulfment Nucleus Localization Heart Process Dendritic Spine Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Lamellipodium Organization Macrophage Differentiation Neuron Projection Organization
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