ATOH8 and CYP3A5

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ATOH8	CYP3A5
Gene Name		atonal homolog 8 (Drosophila)	cytochrome P450, family 3, subfamily A, polypeptide 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding Protein Dimerization Activity	Monooxygenase Activity Iron Ion Binding Oxidoreductase Activity Oxygen Binding Heme Binding Aromatase Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Nervous System Development Cell Differentiation	Xenobiotic Metabolic Process Steroid Metabolic Process Alkaloid Catabolic Process Drug Catabolic Process Small Molecule Metabolic Process Oxidative Demethylation
Pathways			Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Aflatoxin activation and detoxification Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Metabolic disorders of biological oxidation enzymes Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Phase 1 - Functionalization of compounds Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Xenobiotics Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Biological oxidations Defective ACY1 causes encephalopathy
Drugs			Paliperidone
Diseases
GWAS
Protein-Protein Interactions		1 interactors: CYP3A5	3 interactors: ATOH8 ETV5 RDH13
Entrez ID		84913	1577
HPRD ID		09813	05617
Ensembl ID			ENSG00000106258
Uniprot IDs		Q96SQ7	P20815 Q7Z3N0
PDB IDs
Enriched GO Terms of Interacting Partners?		Alkaloid Catabolic Process Alkaloid Metabolic Process Oxidative Demethylation Drug Catabolic Process Drug Metabolic Process Demethylation Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Steroid Metabolic Process	Response To High Light Intensity Male Germ-line Stem Cell Asymmetric Division Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Skeletal Muscle Acetylcholine-gated Channel Clustering Nervous System Development Response To Light Intensity Positive Regulation Of Glial Cell Proliferation Neuromuscular Synaptic Transmission Cell Differentiation Retina Layer Formation Postsynaptic Membrane Organization Eye Photoreceptor Cell Development Stem Cell Division System Development Photoreceptor Cell Development Eye Photoreceptor Cell Differentiation Receptor Clustering Neuromuscular Junction Development Neural Retina Development Positive Regulation Of Gliogenesis Retina Morphogenesis In Camera-type Eye Regulation Of Morphogenesis Of A Branching Structure Multicellular Organismal Development Anatomical Structure Development
Tagcloud ?			antifungal concomitant contributed cyp2c19 delivered explained genotype hsct imply institute interindividual intravenous lansoprazole magnitude march mie odds polymorphism possession ratio recipient recipients tac tacrolimus triazole variability voriconazole vrcz
Tagcloud (Difference) ?			antifungal concomitant contributed cyp2c19 delivered explained genotype hsct imply institute interindividual intravenous lansoprazole magnitude march mie odds polymorphism possession ratio recipient recipients tac tacrolimus triazole variability voriconazole vrcz
Tagcloud (Intersection) ?