ATOH8 and CYP3A5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ATOH8	CYP3A5
Description		atonal bHLH transcription factor 8	cytochrome P450 family 3 subfamily A member 5
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Speck	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity E-box Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Monooxygenase Activity Iron Ion Binding Protein Binding Retinoic Acid 4-hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Heme Binding Metal Ion Binding Testosterone 6-beta-hydroxylase Activity Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity
	Biological Process	Formation Of Primary Germ Layer Negative Regulation Of Endothelial Cell Proliferation Nervous System Development Anatomical Structure Morphogenesis Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Cell Differentiation Tube Formation Positive Regulation Of Endothelial Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Formation Involved In Morphogenesis Myoblast Proliferation Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of MiRNA Transcription	Lipid Hydroxylation Lipid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Estrogen Metabolic Process Alkaloid Catabolic Process Xenobiotic Catabolic Process Retinol Metabolic Process Retinoic Acid Metabolic Process Aflatoxin Metabolic Process Oxidative Demethylation
Pathways			Xenobiotics Aflatoxin activation and detoxification
Drugs			Cannabidiol Diacerein Nabiximols
Diseases
GWAS		Blood metabolite levels ( 31502714) Optic disc size ( 31809533)	Platelet count ( 29403010) Serum metabolite levels ( 23093944 33031748) Ticagrelor levels in individuals with acute coronary syndromes treated with ticagrelor ( 25935875) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)
Interacting Genes		1 interacting genes: CYP3A5	3 interacting genes: ATOH8 ETV5 RDH13
Entrez ID		84913	1577
HPRD ID		09813	05617
Ensembl ID		ENSG00000168874	ENSG00000106258
Uniprot IDs		Q96SQ7	B7Z3P6 P20815
PDB IDs			5VEU
Enriched GO Terms of Interacting Partners?		Lipid Hydroxylation Testosterone 6-beta-hydroxylase Activity Estrogen 16-alpha-hydroxylase Activity Oxidative Demethylation Alkaloid Catabolic Process Aflatoxin Metabolic Process Estrogen 2-hydroxylase Activity Retinoic Acid 4-hydroxylase Activity Alkaloid Metabolic Process Demethylation Toxin Metabolic Process Retinoic Acid Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Xenobiotic Catabolic Process Estrogen Metabolic Process Secondary Metabolic Process Retinol Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Monooxygenase Activity Retinoid Metabolic Process Diterpenoid Metabolic Process Terpenoid Metabolic Process Isoprenoid Metabolic Process Xenobiotic Metabolic Process Iron Ion Binding Heme Binding Olefinic Compound Metabolic Process Intracellular Membrane-bounded Organelle Lipid Modification Hormone Metabolic Process Steroid Metabolic Process Alcohol Metabolic Process Monocarboxylic Acid Metabolic Process Oxidoreductase Activity Regulation Of Hormone Levels	Male Germ-line Stem Cell Asymmetric Division Response To High Light Intensity Germ-line Stem Cell Division Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Skeletal Muscle Acetylcholine-gated Channel Clustering Asymmetric Cell Division Myoblast Proliferation Positive Regulation Of Endothelial Cell Differentiation Response To Light Intensity All-trans-retinol Dehydrogenase (NADP+) Activity Sequence-specific Double-stranded DNA Binding Retinal Metabolic Process
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