ZNF503 and SYNPO2L

		ZNF503	SYNPO2L
Description		zinc finger protein 503	synaptopodin 2 like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Cytoplasm Cytoskeleton Actin Cytoskeleton Z Disc Organelle
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Actin Binding Protein Binding
	Biological Process	Negative Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Neural Precursor Cell Proliferation G1 To G0 Transition Involved In Cell Differentiation	Heart Morphogenesis Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Rho Protein Signal Transduction Sarcomere Organization Positive Regulation Of Stress Fiber Assembly
Pathways
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Mild obesity-related type 2 diabetes ( 34737425) Triglyceride levels ( 32203549) Type 2 diabetes ( 30718926)	Atrial fibrillation ( 22544366 28416818 29290336 29892015 30061737) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heart failure ( 31919418) Hypertrophic cardiomyopathy ( 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Incident atrial fibrillation ( 28416818) Mean arterial pressure ( 27618448) PR interval ( 32439900) Systolic blood pressure ( 27618452)
Interacting Genes		10 interacting genes: ARID5A ATN1 DTX2 FOXH1 KRTAP19-1 KRTAP3-3 KRTAP6-2 PROP1 TENT5B TLE5	7 interacting genes: ACTN1 ACTN2 ACTN3 GOLGA2 PSMB4 SH3RF1 SORBS3
Entrez ID		84858	79933
HPRD ID		15811	15457
Ensembl ID		ENSG00000165655	ENSG00000166317
Uniprot IDs		Q96F45	Q9H987
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription Corepressor Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Androgen Receptor Binding Intermediate Filament Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process	Pseudopodium Focal Adhesion Assembly Cell-substrate Junction Organization Cell-substrate Junction Assembly Sarcomere Cortical Actin Cytoskeleton Actin Filament Muscle Cell Development Vinculin Binding Transmembrane Transporter Binding Cytoskeleton Organization Focal Adhesion Z Disc Integrin Binding Actin Filament Binding Cell Junction Structural Constituent Of Muscle Cell Junction Assembly Actin Cytoskeleton Brush Border Cytoskeletal Protein Binding Platelet Alpha Granule Lumen Actin Cytoskeleton Organization Actin Filament Uncapping Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Actin Binding Actin Filament-based Process Regulation Of Primary Metabolic Process Structural Constituent Of Postsynapse Titin Z Domain Binding Regulation Of The Force Of Skeletal Muscle Contraction Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Cell Junction Organization Platelet Morphogenesis Phospholipase C-activating Angiotensin-activated Signaling Pathway Positive Regulation Of Bone Mineralization Involved In Bone Maturation Cell Projection Microspike Assembly Positive Regulation Of Protein Glycosylation Organelle Organization Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Cytoskeleton Calcium Ion Binding Actin Filament Network Formation Positive Regulation Of Supramolecular Fiber Organization Structural Constituent Of Postsynaptic Actin Cytoskeleton Channel Activator Activity Positive Regulation Of Cytoskeleton Organization FATZ Binding
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