TUBA1C and AQP5

		TUBA1C	AQP5
Description		tubulin alpha 1c	aquaporin 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Microtubule Cytoplasmic Microtubule Cilium Microtubule Cytoskeleton Vesicle	Endoplasmic Reticulum Plasma Membrane Microvillus Basal Plasma Membrane Membrane Apical Plasma Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Nucleotide Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Hydrolase Activity Metal Ion Binding	Protein Binding Water Channel Activity Channel Activity Identical Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Cytoskeleton-dependent Intracellular Transport Cell Division	Water Transport Carbon Dioxide Transport Pancreatic Juice Secretion Odontogenesis Saliva Secretion Camera-type Eye Morphogenesis Protein Homotetramerization Transmembrane Transport Cellular Hypotonic Response
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling	Passive transport by Aquaporins
Drugs		Epothilone D Patupilone CYT997 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Cancer (pleiotropy) ( 27197191) Mean corpuscular hemoglobin ( 32888494) Mean platelet volume ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494)	Allergic rhinitis ( 30013184) Asthma ( 32296059)
Interacting Genes		10 interacting genes: CDKN2A CRK ESR1 LINC00624 LINC00632 OGT SHANK3 SUMO2 SUMO4 VIM	8 interacting genes: CREB3 GLRX HNRNPK KRT31 KRT40 MDFI NOTCH2NLA WNT2
Entrez ID		84790	362
HPRD ID		06747	02706
Ensembl ID		ENSG00000167553	ENSG00000161798
Uniprot IDs		B7Z1K5 F5H5D3 Q9BQE3	P55064
PDB IDs			3D9S 5C5X 5DYE 7STC
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Sumoylation Scaffold Protein Binding Postsynaptic Specialization Assembly Protein-containing Complex Assembly SUMO Transferase Activity Mammary Gland Epithelial Cell Proliferation Protein Tag Activity Cellular Component Assembly Protein-containing Complex Organization Postsynaptic Specialization Organization Regulation Of Generation Of Precursor Metabolites And Energy Ubiquitin-like Protein Ligase Binding Regulation Of Rac Protein Signal Transduction Regulation Of Smooth Muscle Cell Apoptotic Process Protein Modification Process Anti-Mullerian Hormone Receptor Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Ligase Inhibitor Activity L-allo-threonine Aldolase Activity Beta-catenin-TCF Complex Assembly Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly	Structural Molecule Activity Glutathione Disulfide Oxidoreductase Activity Structural Constituent Of Skin Epidermis Tissue Morphogenesis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Positive Regulation Of Deacetylase Activity Structural Constituent Of Cytoskeleton
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