TUBA1C

Gene Name		tubulin, alpha 1c
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Microtubule Cytoplasmic Microtubule Vesicle
	Molecular Function	GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding
	Biological Process	Protein Folding Microtubule-based Process Cytoskeleton-dependent Intracellular Transport Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Protein Polymerization Cell Division
Pathways		Transport of connexons to the plasma membrane Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Hedgehog 'off' state Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane G2/M Transition L1CAM interactions Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes Formation of tubulin folding intermediates by CCT/TriC Intraflagellar transport M Phase Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Post-chaperonin tubulin folding pathway Gap junction trafficking and regulation MHC class II antigen presentation Recruitment of mitotic centrosome proteins and complexes Protein folding Gap junction assembly Gap junction trafficking Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Factors involved in megakaryocyte development and platelet production Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion Chaperonin-mediated protein folding Signaling by Hedgehog Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs		Epothilone D Epothilone B 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
Diseases
GWAS
Protein-protein Interactions		2 interactors: CDKN2A SUMO4
Entrez ID		84790
HPRD ID		06747
Ensembl ID		ENSG00000167553
Uniprot IDs		F5H5D3 Q9BQE3
PDB IDs
Enriched GO Terms of Interacting Partners?		Senescence-associated Heterochromatin Focus Assembly Positive Regulation Of Cellular Senescence Positive Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Macrophage Apoptotic Process Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Cell Aging Protein Modification By Small Protein Conjugation Positive Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of T Cell Differentiation In Thymus Heterochromatin Assembly Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Sumoylation Regulation Of Smooth Muscle Cell Apoptotic Process Heterochromatin Organization Regulation Of Macrophage Apoptotic Process Positive Regulation Of Signal Transduction By P53 Class Mediator Replicative Senescence Negative Regulation Of B Cell Proliferation Regulation Of Protein Sumoylation Protein Destabilization Regulation Of Cellular Senescence Regulation Of Execution Phase Of Apoptosis Protein Sumoylation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Somatic Stem Cell Division Cellular Senescence Regulation Of Protein Export From Nucleus Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Leukocyte Apoptotic Process Protein K63-linked Ubiquitination Negative Regulation Of T Cell Differentiation Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of B Cell Activation Regulation Of Myeloid Cell Apoptotic Process Stem Cell Division Regulation Of Signal Transduction By P53 Class Mediator Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Lymphocyte Differentiation Negative Regulation Of Cell-substrate Adhesion Regulation Of Muscle Cell Apoptotic Process Regulation Of B Cell Proliferation Negative Regulation Of T Cell Proliferation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Response To DNA Damage Stimulus Cell Aging Apoptotic Mitochondrial Changes
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