ST6GAL2 and AFF3

		ST6GAL2	AFF3
Description		ST6 beta-galactoside alpha-2,6-sialyltransferase 2	ALF transcription elongation factor 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane Golgi Cisterna Membrane	Nucleus Nucleoplasm Cytosol Nuclear Body Super Elongation Complex
	Molecular Function	Beta-galactoside Alpha-2,6-sialyltransferase Activity Protein Binding Sialyltransferase Activity Transferase Activity Glycosyltransferase Activity	DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity
	Biological Process	Carbohydrate Metabolic Process Protein Glycosylation Oligosaccharide Metabolic Process Sialylation	Regulation Of DNA-templated Transcription Regulation Of Gene Expression Response To Tumor Necrosis Factor Embryonic Hindlimb Morphogenesis
Pathways		Sialic acid metabolism
Drugs
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Serum immune biomarker levels ( 32066700)	A body shape index ( 34021172) Adult body size ( 32376654) Age at first birth ( 27798627) Albumin-globulin ratio ( 29403010) Apolipoprotein A1 levels ( 32203549) Arthritis (juvenile idiopathic) ( 33106285) Asthma ( 34103634) Autoimmune traits (pleiotropy) ( 30572963) Cannabis dependence symptom count ( 27028160) Celiac disease ( 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Extremely high intelligence ( 29520040) Gastroesophageal reflux disease ( 31527586 34187846) General cognitive ability ( 29844566) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 31217584) Hip circumference adjusted for BMI ( 34021172) Household income ( 27818178) Household income (MTAG) ( 31844048) IgG levels ( 28628107) Immature fraction of reticulocytes ( 32888494) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 29617998) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Kidney disease (end stage renal disease vs non-end stage renal disease) in type 1 diabetes ( 27647854) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Multisite chronic pain ( 33830993) Non-albumin protein levels ( 29403010) Number of children ever born ( 27798627) Plateletcrit ( 27863252 32888494) Red blood cell count ( 27863252) Refractive astigmatism ( 30306274) Regular attendance at a religious group ( 29970889) Rheumatoid arthritis ( 24390342 30572963 24782177 23143596 30423114) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Serum total protein levels ( 29403010) Triglyceride levels ( 34074324) Type 1 diabetes ( 25751624 34127860 17554260) Type 1 diabetes nephropathy ( 23028342) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		16 interacting genes: AQP6 CD53 CREB3 FNDC9 GIPC3 GOLM1 GPX8 HSD17B13 PGRMC2 PSCA SLC26A1 SLC39A2 SLC7A1 TIMMDC1 TMEM14B TMEM237
Entrez ID		84620	3899
HPRD ID		12237	03272
Ensembl ID		ENSG00000144057	ENSG00000144218
Uniprot IDs		Q96JF0	P51826 Q8NAP7
PDB IDs
Enriched GO Terms of Interacting Partners?			Interleukin-18 Receptor Complex Interleukin-18 Receptor Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Interleukin-18-mediated Signaling Pathway Cellular Response To Interleukin-18 Positive Regulation Of NF-kappaB Transcription Factor Activity Inflammatory Response Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Lymphocyte Mediated Immunity Interleukin-18 Binding Beta-galactoside Alpha-2,6-sialyltransferase Activity Response To Interleukin-18 Regulation Of DNA-binding Transcription Factor Activity Regulation Of Lymphocyte Mediated Immunity CARD8 Inflammasome Complex Assembly Positive Regulation Of Protein Localization To Lysosome Positive Regulation Of Immune Effector Process Signaling Receptor Activity Interleukin-1 Receptor Activity Positive Regulation Of T-helper 1 Cell Cytokine Production NLRP1 Inflammasome Complex Assembly Immune Response Adaptive Immune Response Sialylation Dipeptidyl-peptidase Activity Negative Regulation Of Bone Resorption Defense Response T-helper 1 Cell Differentiation Pyroptotic Cell Death Negative Regulation Of Bone Remodeling Sialyltransferase Activity Cytokine-mediated Signaling Pathway Positive Regulation Of T-helper 1 Type Immune Response Regulation Of Immune System Process Hydrolase Activity Neutrophil Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of T Cell Cytokine Production Aminopeptidase Activity Negative Regulation Of Osteoclast Differentiation
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