WDR24 and SESN1

Number of citations of the paper that reports this interaction (PubMedID 25263562)
44

Data Source:
BioGRID (pull down)

		WDR24	SESN1
Description		WD repeat domain 24	sestrin 1
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Vacuolar Membrane Cytosol Membrane GATOR2 Complex	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol GATOR2 Complex
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor L-leucine Binding
	Biological Process	Cytoplasmic Translation Autophagy Regulation Of Autophagy Positive Regulation Of Macroautophagy Protein Ubiquitination Cellular Response To Nutrient Levels Positive Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation TORC1 Signaling Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Protein Localization To Lysosome Protein K6-linked Ubiquitination Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling	Positive Regulation Of Macroautophagy Negative Regulation Of Cell Growth Cellular Response To Amino Acid Starvation Cellular Response To Glucose Starvation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Amino Acid Stimulus Cellular Response To L-leucine Reactive Oxygen Species Metabolic Process Cellular Oxidant Detoxification Regulation Of Response To Reactive Oxygen Species Negative Regulation Of TORC1 Signaling Cellular Response To Leucine Starvation
Pathways		Amino acids regulate mTORC1	Amino acids regulate mTORC1 KEAP1-NFE2L2 pathway
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Hip circumference adjusted for BMI ( 34021172) Smoking initiation (ever regular vs never regular) ( 30679032)	Asthma ( 32296059) Birth weight ( 31043758) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252) Metabolite levels ( 23823483) Offspring birth weight ( 31043758) Prostate cancer ( 23535732)
Interacting Genes		5 interacting genes: APPBP2 FBXO7 SESN1 SESN3 SRPK2	3 interacting genes: MIOS PRDX1 WDR24
Entrez ID		84219	27244
HPRD ID		15665	07310
Ensembl ID		ENSG00000127580	ENSG00000080546
Uniprot IDs		Q96S15	Q9Y6P5
PDB IDs		7UHY
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macroautophagy L-leucine Binding Oxidoreductase Activity, Acting On Peroxide As Acceptor Regulation Of Response To Reactive Oxygen Species GATOR2 Complex Cellular Response To L-leucine Cellular Response To Leucine Starvation Response To L-leucine Positive Regulation Of Autophagy Regulation Of Macroautophagy Regulation Of Response To Oxidative Stress Cellular Response To Glucose Starvation Regulation Of Autophagy Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Negative Regulation Of TOR Signaling Cellular Response To Amino Acid Stimulus Ubiquitin-like Ligase-substrate Adaptor Activity Positive Regulation Of Catabolic Process Regulation Of TORC1 Signaling Response To Amino Acid Regulation Of TOR Signaling Negative Regulation Of Intracellular Signal Transduction Lewy Body Core Nuclear Speck Organization Cellular Response To Starvation Response To Starvation Regulation Of Neuron Apoptotic Process Cellular Response To Nutrient Levels R-loop Processing TORC2 Complex Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway TORC2 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signal Transduction Nuclear Body Organization Cul2-RING Ubiquitin Ligase Complex Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Nucleus Positive Regulation Of Mitophagy Protein Modification Process	GATOR2 Complex Positive Regulation Of TORC1 Signaling Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling Negative Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Regulation Of TORC1 Signaling Oligodendrocyte Progenitor Proliferation Regulation Of TOR Signaling Cellular Response To Starvation Response To Starvation Cellular Response To Nutrient Levels Thioredoxin-dependent Peroxiredoxin Activity Peroxiredoxin Activity Thioredoxin Peroxidase Activity Central Nervous System Myelin Formation Lysosomal Membrane Regulation Of Intracellular Signal Transduction Removal Of Superoxide Radicals Erythrocyte Homeostasis Response To Nutrient Levels Lysosome Myelin Assembly Vacuolar Membrane Hydrogen Peroxide Catabolic Process Antioxidant Activity Protein K6-linked Ubiquitination Regulation Of Signal Transduction Peroxidase Activity Hydrogen Peroxide Metabolic Process Cell Population Proliferation Myeloid Cell Homeostasis Negative Regulation Of Intracellular Signal Transduction Response To Stress Regulation Of Stress-activated MAPK Cascade Cell Redox Homeostasis Natural Killer Cell Mediated Immunity Superoxide Metabolic Process Natural Killer Cell Mediated Cytotoxicity Regulation Of Cell Communication Regulation Of Stress-activated Protein Kinase Signaling Cascade Fibroblast Proliferation Regulation Of Signaling Oligodendrocyte Differentiation Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Natural Killer Cell Activation Canonical NF-kappaB Signal Transduction Protein Localization To Lysosome
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