TAF3 and GNAL

		TAF3	GNAL
Description		TATA-box binding protein associated factor 3	G protein subunit alpha L
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GO Annotations	Cellular Component	Male Germ Cell Nucleus Nucleus Nucleoplasm Transcription Factor TFIID Complex Nuclear Membrane	Cytoplasm Heterotrimeric G-protein Complex Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	P53 Binding Protein Binding Zinc Ion Binding RNA Polymerase II General Transcription Initiation Factor Activity Metal Ion Binding Protein Heterodimerization Activity Histone H3K4me3 Reader Activity Transcription Regulator Inhibitor Activity	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Adenylate Cyclase Regulator Activity Hydrolase Activity Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Transcription By RNA Polymerase II MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Maintenance Of Protein Location In Nucleus Positive Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of Signal Transduction By P53 Class Mediator	Response To Amphetamine Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Sensory Perception Of Chemical Stimulus Sensory Perception Of Smell Response To Caffeine
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Olfactory Signaling Pathway Olfactory Signaling Pathway
Drugs
Diseases
GWAS		Asthma ( 31959851) Cadmium levels ( 26025379) Red blood cell count ( 32888494)	Age at first sexual intercourse ( 27089180) Alcohol dependence ( 26365420) Metabolite levels ( 23823483) QT interval (drug interaction) ( 23459443) Sensation seeking ( 30718321) Tandem gait ( 26219847) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		6 interacting genes: H3-4 H3C1 HMGB1 KPNA2 KPNB1 TAF10
Entrez ID		83860	2774
HPRD ID		19377	00758
Ensembl ID		ENSG00000165632	ENSG00000141404
Uniprot IDs		A0A8I5KR98 Q5VWG9	A8K1Y9 P38405
PDB IDs		5C13 5WXG 5WXH 5XMY 6MZD 6MZL 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7EGD 7EGE 7EGF 7EGI 7EGJ 7ENA 7ENC 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS	8EL8 8IW1 8KGK 8KH4
Enriched GO Terms of Interacting Partners?		NLS-dependent Protein Nuclear Import Complex Positive Regulation Of Viral Life Cycle NLS-bearing Protein Import Into Nucleus Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity Protein-DNA Complex Assembly Chromatin Remodeling Chromatin Organization Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Positive Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Viral Process SAGA Complex Assembly Transferase Activity, Transferring One-carbon Groups Thymidylate Synthase Activity Regulation Of Transcription Initiation By RNA Polymerase II Adenylate Cyclase Regulator Activity Regulation Of DNA Metabolic Process Regulation Of Mismatch Repair Regulation Of DNA-templated Transcription Initiation C-X-C Chemokine Binding Alphav-beta3 Integrin-HMGB1 Complex T-helper 1 Cell Activation Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of Mismatch Repair Plasmacytoid Dendritic Cell Activation Regulation Of Viral Life Cycle Ficolin-1-rich Granule Lumen Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Glycogen Catabolic Process Negative Regulation Of Apoptotic Cell Clearance Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Regulation Of Viral Process Mitotic Chromosome Movement Towards Spindle Pole Import Into Nucleus Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus RNA Import Into Nucleus Viral Penetration Into Host Nucleus Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Lateral Mesodermal Cell Differentiation Allantois Development DTMP Biosynthetic Process Pyrimidine Deoxyribonucleoside Monophosphate Biosynthetic Process DTTP Biosynthetic Process Nucleosome Nucleosome Assembly Nucleosome Organization Spermatogonial Cell Division	Negative Regulation Of Leukocyte Migration Negative Regulation Of Mononuclear Cell Migration Negative Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Endocytosis Membrane Raft Polarization Myeloid Dendritic Cell Activation Involved In Immune Response Regulation Of Mononuclear Cell Migration Phenylpyruvate Tautomerase Activity Positive Regulation Of Arachidonate Secretion Positive Regulation Of Prostaglandin Secretion Involved In Immune Response Regulation Of Signal Transduction By P53 Class Mediator Dopachrome Isomerase Activity Negative Regulation Of Mature B Cell Apoptotic Process Negative Regulation Of Membrane Tubulation Positive Regulation Of Clathrin-dependent Endocytosis Actin Cap Negative Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Positive T Cell Selection Positive Regulation Of Cellular Component Organization Membrane Raft Distribution Positive Thymic T Cell Selection T Cell Receptor Binding Positive Regulation Of Transport Locomotion Immunological Synapse Formation Small GTPase-mediated Signal Transduction Alpha-beta T Cell Proliferation Actin Cytoskeleton Organization Pinocytosis Macropinocytosis Negative Thymic T Cell Selection Negative T Cell Selection Membrane Raft Localization Plasma Membrane Chemotaxis Regulation Of Endocytosis Establishment Of T Cell Polarity Regulation Of Leukocyte Migration Prostaglandin Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Prostanoid Biosynthetic Process Regulation Of Arachidonate Secretion Negative Regulation Of B Cell Apoptotic Process Negative Regulation Of Macrophage Migration Positive Regulation Of Icosanoid Secretion Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Macrophage Chemotaxis Protein Homotrimerization
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