SETDB2 and ARL14EP

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology)

		SETDB2	ARL14EP
Description		SET domain bifurcated histone lysine methyltransferase 2	ARF like GTPase 14 effector protein
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol	Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K9 Monomethyltransferase Activity	Protein Binding
	Biological Process	Mitotic Cell Cycle Heart Looping Chromatin Organization Chromatin Remodeling Chromosome Segregation Negative Regulation Of Gene Expression Methylation Negative Regulation Of DNA-templated Transcription Cell Division Heterochromatin Organization Left/right Axis Specification
Pathways		PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278)	Adult body size ( 32376654) Age at first birth ( 34211149) Chronotype ( 30696823) Heel bone mineral density ( 30598549) Morning person ( 30696823) Polycystic ovary syndrome ( 26284813 30566500) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 30224653)
Interacting Genes		1 interacting genes: ARL14EP	3 interacting genes: KANK2 PLEKHF2 SETDB2
Entrez ID		83852	120534
HPRD ID		09712	08796
Ensembl ID		ENSG00000136169	ENSG00000152219
Uniprot IDs		Q96T68	Q8N8R7
PDB IDs		5TFP 8HFP	8HFP
Enriched GO Terms of Interacting Partners?			BLOC-2 Complex Negative Regulation Of Vitamin D Receptor Signaling Pathway
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