ATG10 and DNAI1

		ATG10	DNAI1
Description		autophagy related 10	dynein axonemal intermediate chain 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Extracellular Region Cytoplasm Centrosome Cytoskeleton Microtubule Cilium Microtubule Cytoskeleton Dynein Complex Outer Dynein Arm Cell Projection Glial Cell Projection 9+2 Motile Cilium Dynein Axonemal Particle
	Molecular Function	Protein Binding Transferase Activity Atg12 Transferase Activity Ubiquitin-like Protein Transferase Activity Atg12 Conjugating Enzyme Activity	Cytoskeletal Motor Activity Protein Binding Dynein Light Chain Binding Dynein Heavy Chain Binding
	Biological Process	Autophagosome Assembly Mitophagy Autophagy ER Overload Response Protein Transport Protein Modification By Small Protein Conjugation	Cilium Movement Epithelial Cilium Movement Involved In Extracellular Fluid Movement Determination Of Left/right Symmetry Heart Development Insulin Receptor Signaling Pathway Cell Projection Organization Flagellated Sperm Motility Outer Dynein Arm Assembly
Pathways		Macroautophagy Macroautophagy
Drugs
Diseases			Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS		Adventurousness ( 30643258) Airway imaging phenotypes ( 26030696) Breast cancer ( 25751625 29059683) Carotid intima media thickness (mean) ( 31801372) General risk tolerance (MTAG) ( 30643258) HDL cholesterol levels in HIV infection ( 33109212) LDL cholesterol levels in HIV infection ( 33109212)	Anti-drug antibodies in autoimmune disease (time to event) ( 33125391)
Interacting Genes		4 interacting genes: ATG12 ATG5 ATG7 IRGM	2 interacting genes: PAFAH1B1 SQSTM1
Entrez ID		83734	27019
HPRD ID		16497	05080
Ensembl ID		ENSG00000152348	ENSG00000122735
Uniprot IDs		Q9H0Y0	A0A087WWV9 A0A140VJI0 Q9UI46
PDB IDs			8J07
Enriched GO Terms of Interacting Partners?		Autophagosome Organization Autophagosome Assembly Regulation Of Autophagosome Maturation Negative Regulation Of Defense Response To Virus Piecemeal Microautophagy Of The Nucleus Microautophagy Nucleophagy Vacuole Organization Positive Regulation Of Viral Translation Negative Regulation Of Type I Interferon Production Atg8-family Ligase Activity Autophagy Regulation Of Defense Response To Virus Autophagy Of Mitochondrion Atg12-Atg5-Atg16 Complex Phagocytic Vesicle Membrane Negative Regulation Of Innate Immune Response Cellular Response To Nitrogen Starvation Regulation Of Protein-containing Complex Disassembly Regulation Of Type I Interferon Production Transferase Complex Macroautophagy Regulation Of Macroautophagy Organelle Assembly Phagophore Assembly Site Membrane Negative Regulation Of Immune Response Protein Lipidation Negative Regulation Of Defense Response Cellular Component Assembly Negative Regulation Of Cytokine Production Autophagosome Maturation Autophagosome Membrane Regulation Of Autophagy Mitophagy Response To Virus Positive Regulation Of Viral Process Regulation Of Innate Immune Response Autophagosome Negative Regulation Of Immune System Process Atg8 Activating Enzyme Activity Atg12 Activating Enzyme Activity Protein Lipidation Involved In Autophagosome Assembly Positive Regulation Of Catabolic Process Regulation Of Protein Modification Process Axoneme Otolith Development C-terminal Protein Lipidation Regulation Of Viral Process Protein-containing Complex Disassembly Catabolic Process	Autophagy Of Mitochondrion DNA-templated Transcription Positive Regulation Of Macrophage Apoptotic Process Nucleobase-containing Compound Biosynthetic Process Intracellular Signal Transduction Negative Regulation Of Protein Ubiquitination Stem Cell Division Protein K63-linked Ubiquitination Autophagy Cell Population Proliferation Ligase Inhibitor Activity Negative Regulation Of Post-translational Protein Modification Apoptotic Process Involved In Mammary Gland Involution Stem Cell Population Maintenance Catabolic Process Glycine Decarboxylation Via Glycine Cleavage System Response To Lipoic Acid Glycine Cleavage Complex Glycine Dehydrogenase (decarboxylating) Activity Pyridoxal Binding Glycine Catabolic Process Response To Methylamine Limb Morphogenesis Cumulus Cell Differentiation Natriuretic Peptide Receptor Activity Vestibulocochlear Nerve Maturation Nerve Maturation C-di-GMP Signaling Granulosa Cell Differentiation Activation Of Meiosis Involved In Egg Activation Neuromuscular Process Gastric Emptying Negative Regulation Of Oocyte Maturation Microtubule Sliding 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Forebrain Development Astral Microtubule Hippocampus Development Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity Central Region Of Growth Cone Neural Plate Development Central Nervous System Segmentation Determination Of Left/right Asymmetry In Nervous System Mitophagy Brown Fat Cell Proliferation Amphisome Atg12 Transferase Activity Atg12 Conjugating Enzyme Activity Maintenance Of Cell Number Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution
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