EPPK1 and STK4

Number of citations of the paper that reports this interaction (PubMedID 39664081)
50

Data Source:
BioGRID (affinity chromatography technology, proximity labelling technology)

		EPPK1	STK4
Description		epiplakin 1	serine/threonine kinase 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Basolateral Plasma Membrane Apicolateral Plasma Membrane Cell Junction Hemidesmosome Cell Projection Keratin Filament Intermediate Filament Cytoskeleton Anchoring Junction Cell Periphery Perinucleolar Compartment	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body Protein-containing Complex
	Molecular Function	RNA Binding Structural Molecule Activity Intermediate Filament Binding Keratin Filament Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Keratinocyte Proliferation Negative Regulation Of Cell Migration Wound Healing Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Intermediate Filament Bundle Assembly Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Keratinocyte Migration Negative Regulation Of Wound Healing Regulation Of Epithelium Regeneration	Cell Morphogenesis Branching Involved In Blood Vessel Morphogenesis Neural Tube Formation Positive Regulation Of Protein Phosphorylation Endocardium Development Protein Phosphorylation Protein Import Into Nucleus Apoptotic Process Signal Transduction Central Nervous System Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Anatomical Structure Morphogenesis Peptidyl-serine Phosphorylation Keratinocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Organ Growth Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Organ Growth Protein Autophosphorylation Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Protein Stabilization Protein Tetramerization Canonical Wnt Signaling Pathway Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Hepatocyte Apoptotic Process Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate
Pathways			Signaling by Hippo
Drugs
Diseases
GWAS		Knee osteoarthritis ( 28916551) Multiple sclerosis ( 31604244)	Bipolar disorder ( 31043756 33263727 34002096) Mean platelet volume ( 32888494) Platelet count ( 32888494)
Interacting Genes		4 interacting genes: EGFR RNF10 SUMO2 UCHL5	25 interacting genes: AKT1 CASP3 CNKSR1 CSN1S1 DAXX DDIT4L H2BC21 HSPA4 IL2RG KEAP1 LATS1 MBP NEDD4 OGT PICK1 RASSF1 RASSF5 RNF31 RNF6 SAV1 SGMS1 SIRT1 THAP12 TP53 TRIM69
Entrez ID		83481	6789
HPRD ID		06500	05395
Ensembl ID		ENSG00000261150	ENSG00000101109
Uniprot IDs		P58107	A0A087WVN8 Q13043
PDB IDs			2JO8 3COM 4NR2 4OH8 5TWG 5TWH 6YAT 8A5J 8PAV 8PAW
Enriched GO Terms of Interacting Partners?		Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of DNA Repair Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Embryonic Organ Development Positive Regulation Of Protein Kinase C Signaling Positive Regulation Of DNA-templated Transcription Regulation Of DNA Replication Epidermal Growth Factor Receptor Activity Negative Regulation Of Protein Catabolic Process Shc-EGFR Complex Positive Regulation Of RNA Metabolic Process Regulation Of Protein Metabolic Process Multivesicular Body, Internal Vesicle Lumen Protein Modification Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Hepatocyte Apoptotic Process Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Positive Regulation Of Protein Metabolic Process Epithelial Cell Proliferation Epidermal Growth Factor Binding Cell Morphogenesis Post-translational Protein Modification Regulation Of Ubiquitin-dependent Protein Catabolic Process Primitive Hemopoiesis Regulation Of Protein Kinase C Signaling Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Endocardium Development Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Negative Regulation Of Developmental Process Regulation Of DNA Repair Positive Regulation Of Protein Phosphorylation Regulation Of Developmental Process Regulation Of Primary Metabolic Process Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Macromolecule Biosynthetic Process ERBB2-EGFR Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA Metabolic Process Neural Tube Formation Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Forebrain Morphogenesis	Apoptotic Process Programmed Cell Death Regulation Of Autophagy Cell Death Intracellular Signal Transduction Regulation Of Macroautophagy Response To Stress Regulation Of Proteolysis Identical Protein Binding Regulation Of Protein Metabolic Process Keratinocyte Differentiation Positive Regulation Of Protein Metabolic Process Response To UV Immune System Process Protein Modification Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Hippo Signaling Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Ubiquitination Regulation Of Programmed Cell Death Positive Regulation Of Proteolysis Regulation Of Glucose Metabolic Process Epidermal Cell Differentiation Glial Cell Apoptotic Process Regulation Of Programmed Necrotic Cell Death PML Body Keratin Filament Binding Signal Transduction Transcription Regulator Inhibitor Activity Positive Regulation Of Metabolic Process Regulation Of Endodeoxyribonuclease Activity Nucleus Regulation Of Post-translational Protein Modification T Cell Differentiation In Thymus Stress-induced Premature Senescence Protein Ubiquitination Post-translational Protein Modification Cytoplasm Regulation Of Hippo Signaling Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Nutrient Levels Leukocyte Apoptotic Process Cellular Response To Glucose Starvation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process Regulation Of Transcription By Glucose Cellular Response To Decreased Oxygen Levels Protein Polyubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of Signaling
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