UBL4A and ERP27

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UBL4A	ERP27
Description		ubiquitin like 4A	endoplasmic reticulum protein 27
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane BAT3 Complex	Endoplasmic Reticulum Endoplasmic Reticulum Lumen
	Molecular Function	Protein Binding Ubiquitin-like Protein Transferase Activity Protein-folding Chaperone Binding	Protein Disulfide Isomerase Activity Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Protein Stability Protein Modification Process Tail-anchored Membrane Protein Insertion Into ER Membrane	Protein Folding Response To Unfolded Protein Response To Endoplasmic Reticulum Stress
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS		Neutrophil count ( 32888494)	Finger osteoarthritis severity (hand Klsum) ( 33055079) Hand grip strength ( 29313844) Hand osteoarthritis severity (hand Klsum) ( 33055079) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Osteoarthritis of the hand ( 28855172)
Interacting Genes		13 interacting genes: AMFR APP CDCA7L ERP27 MEOX2 PER2 RNF126 S100P SGTA SGTB TRAF4 TRIM54 USP13	10 interacting genes: BLOC1S2 C12orf60 GOLGA8F MED20 PDIA3 SGTA UBL4A UBQLN1 UBQLN2 UBQLN4
Entrez ID		8266	121506
HPRD ID		02417	08723
Ensembl ID		ENSG00000102178	ENSG00000139055
Uniprot IDs		P11441	F5GYS6 Q96DN0
PDB IDs		2DZI 4WWR 4X86 7RU9 7RUA 7RUC	2L4C 4F9Z
Enriched GO Terms of Interacting Partners?		BAT3 Complex Binding TRC Complex Protein-folding Chaperone Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Cellular Response To Stress Regulation Of Response To Endoplasmic Reticulum Stress Protein K27-linked Ubiquitination Positive Regulation Of ERAD Pathway Transition Metal Ion Binding Regulation Of Neurotransmitter Uptake Growth Cone Regulation Of ERAD Pathway Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Response To Endoplasmic Reticulum Stress Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway	Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Polyubiquitin Modification-dependent Protein Binding Regulation Of Proteasomal Protein Catabolic Process Response To Endoplasmic Reticulum Stress Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane ERAD Pathway Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Targeting To ER Protein Insertion Into ER Membrane Macromolecule Catabolic Process Regulation Of Cellular Response To Stress Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Macroautophagy Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Autophagy Negative Regulation Of Store-operated Calcium Channel Activity Protein Targeting To Membrane Protein Insertion Into Membrane Cellular Response To Stress Tapasin-ERp57 Complex TRC Complex Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Autophagy Nuclear Proteasome Complex Autophagosome Assembly Autophagosome Organization BAT3 Complex Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Autophagosome Maturation Identical Protein Binding Extrinsic Apoptotic Signaling Pathway Proteasomal Protein Catabolic Process BAT3 Complex Binding Negative Regulation Of Clathrin-dependent Endocytosis Catabolic Process Cytosolic Proteasome Complex Positive Regulation Of Catabolic Process
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