MKKS and SELENOP

		MKKS	SELENOP
Description		MKKS centrosomal shuttling protein	selenoprotein P
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Motile Cilium Ciliary Basal Body Kinociliary Basal Body	Extracellular Region Extracellular Space Platelet Dense Granule Lumen Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Unfolded Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Selenium Binding
	Biological Process	Heart Looping Developmental Process Involved In Reproduction Protein Folding Spermatid Development Determination Of Left/right Symmetry Heart Development Visual Perception Sensory Perception Of Smell Gonad Development Gene Expression Negative Regulation Of Gene Expression Artery Smooth Muscle Contraction Striatum Development Hippocampus Development Cerebral Cortex Development Negative Regulation Of Actin Filament Polymerization Melanosome Transport Developmental Process Leptin-mediated Signaling Pathway Social Behavior Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Positive Regulation Of Multicellular Organism Growth Vasodilation Response To Leptin Fat Cell Differentiation Photoreceptor Cell Maintenance Negative Regulation Of Blood Pressure Intracellular Transport Animal Organ Development System Development Brain Morphogenesis Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Chaperone-mediated Protein Complex Assembly Cartilage Development Regulation Of Stress Fiber Assembly Pigment Granule Aggregation In Cell Center Convergent Extension Involved In Gastrulation Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Face Development Response To Inositol Non-motile Cilium Assembly	Selenium Compound Metabolic Process Response To Oxidative Stress Brain Development Locomotory Behavior Post-embryonic Development Response To Selenium Ion Sexual Reproduction Regulation Of Growth
Pathways		BBSome-mediated cargo-targeting to cilium	Platelet degranulation
Drugs			Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		46,XX disorders of sex development (Other), including: Mullerian aplasia and hyperandrogenism; McKusick-Kaufman syndrome Bardet-Biedl syndrome (BBS)
GWAS
Interacting Genes		4 interacting genes: APP CDR2 PTN ZBED1	5 interacting genes: EGFR EP300 MEOX2 THRA VHL
Entrez ID		8195	6414
HPRD ID		05356	03286
Ensembl ID		ENSG00000125863	ENSG00000250722
Uniprot IDs		B7Z3W9 Q9NPJ1	P49908
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Long-term Synaptic Potentiation Response To Auditory Stimulus Molecular Function Activator Activity Dendrite Membrane Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Dendrite Development Phospholipase C-activating Endothelin Receptor Signaling Pathway Protein Autosumoylation Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Leukocyte Chemotaxis Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Interleukin-15 Receptor Activity Interleukin-2 Binding Interleukin-2 Receptor Activity Interleukin-2 Receptor Complex Dendrite Regeneration Ossification Involved In Bone Remodeling Selenium Compound Metabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Memory Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Modulation Of Chemical Synaptic Transmission Axon Midline Choice Point Recognition Recycling Endosome Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Positive Regulation Of Chemotaxis	Animal Organ Morphogenesis Negative Regulation Of Protein-containing Complex Assembly Anatomical Structure Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Learning Or Memory Positive Regulation Of RNA Metabolic Process Nervous System Process Cognition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Catabolic Process Cellular Response To Amino Acid Stimulus Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Multivesicular Body, Internal Vesicle Lumen Skeletal Muscle Tissue Development Regulation Of Receptor Signaling Pathway Via JAK-STAT Peptidyl-lysine Propionylation Chromatin DNA Binding Swimming Pattern Specification Process Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Regulation Of Protein-containing Complex Assembly Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Response To Amino Acid Regulation Of Cellular Response To Stress Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Shc-EGFR Complex Animal Organ Development Developmental Process System Process Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Regulation Of TORC1 Signaling Protein Propionyltransferase Activity Negative Regulation Of Autophagy Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity
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